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Osteoarthritis
Published in Nicole M. Farmer, Andres Victor Ardisson Korat, Cooking for Health and Disease Prevention, 2022
Nobiletin, a polymethoxy flavone found in citrus skin, may be particularly protective for OA. In vitro studies show that synovial cells and cartilage chondrocytes when exposed to nobiletin (16–64 µM) inhibited cartilage degradation by interfering with ADAMTS-4 and 5 activity as well as activating an MMP inhibitor (Xie et al., 2019). Other in vitro studies report the mechanism of nobiletin’s ability to reduce the expression of inflammatory mediators maybe from the inhibition of the phosphorylation of the pro-inflammatory factor, NF-κB (Lin et al., 2019).
Bioflavonoids
Published in Hafiz Ansar Rasul Suleria, Megh R. Goyal, Masood Sadiq Butt, Phytochemicals from Medicinal Plants, 2019
Muhammad Sajid Arshad, Urooj Khan, Ali Imran, Hafiz Ansar Rasul Suleria
Flavonoids have shown to prevent atherosclerosis in animal models.42 Various flavonoids show several antioxidant activities associated with atherosclerosis prevention. Isoflavone genistein in the cell-free and the cell-mediated systems has revealed antioxidant activity. These flavonoids also include LDL particles that prevent the oxidation of LDL and protect the vascular cells from oxidation.54 Nobiletin has a wide range of activities similar to that of antioxidants. It inhibits the development of oxidants by means of three systems produced by the RAW 264.7 cell line, such as xanthine oxidase system, oxidative stress induced by TPA and also NO.77,78
Flavonoids with Preclinical Antidepressant-Like Effects
Published in Scott Mendelson, Herbal Treatment of Major Depression, 2019
Nobiletin is an O-methylated flavone from citrus. Acute oral administration of nobiletin to mice decreased the immobility time in both the forced swim and tail suspension tests.63 Chronically administered nobiletin restored appetite for sucrose in rats that had been subjected to chronic unpredictable stress. This antidepressant-like effect was accompanied by decreases in serum corticosterone. This treatment also attenuated the decreases in BDNF and enhanced activation of the TrkB and synapsin I in the hippocampi of these animals.64 Nobiletin also spared cultured neurons from the cytotoxic effects of prolonged exposure to corticosterone, thus showing an antistress effect.65
Mechanism of action of Tripterygium wilfordii for treatment of idiopathic membranous nephropathy based on network pharmacology
Published in Renal Failure, 2022
Honghong Shi, Yanjuan Hou, Xiaole Su, Jun Qiao, Qian Wang, Xiaojiao Guo, Zhihong Gao, Lihua Wang
Clinical studies have shown that T. wilfordii appears to be promising and safe for the treatment of IMN patients [10,11]. However, the mechanism remains unclear. In the present study, we used a network pharmacological approach to identify the major constituents, potential therapeutic targets and significant pathways of T. wilfordii for IMN. We found that the main active components of T. wilfordii (triptolide, kaempferol, and nobiletin) play important roles in the treatment of IMN. Kaempferol, the main component of T. wilfordii, has been suggested to inhibit hyperglycemia-induced activation of inflammatory cytokines, TGF-β1 expression, and oxidative stress in NRK-52E and human renal tubular epithelial cells [24]. Triptolide, is extracts of T. wilfordii and frequently used to treat inflammatory and autoimmune disease, e.g., systemic lupus erythematosus, nephritis, psoriasis, and rheumatoid arthritis [25]. And, triptolide can inhibits the secretion of many cytokines, adhesion molecules, and chemokines and affects the functions of renal tubular epithelial cells [26], and reduces established proteinuria and podocyte injury in IMN [27]. In addition, nobiletin has anti-oxidant, anti-inflammatory and anti-apoptotic effects, and can attenuated tubular injury by inhibiting activation of apoptotic pathways and DNA damage [28].
Evaluation of the Effects of Nobiletin on Toll-Like Receptor 3 Signaling Pathways in Prostate Cancer In Vitro
Published in Nutrition and Cancer, 2021
Asuman Deveci Ozkan, Mehmet Sarihan, Suleyman Kaleli
Flavonoids are phytochemicals found in fruits, vegetables, teas and wines and there are more than 400 flavonoids in foods such as fruits, vegetables and tea (19–21). Potential therapeutic effects of flavonoids such as tangeretin, nobiletin, hesperetin, hesperidin, naringenin and naringin are known in treating of cancer. In the literature, flavonoids have an anti-proliferative effect on certain types of cancer through different molecular mechanisms due to their In Vitro anti-carcinogenic properties (22–24). Nobiletin (NOB) as a nontoxic dietary citrus flavonoid is noteworthy nowadays (25–27). Although the potential therapeutic effects of NOB on different TLR signaling pathways (TLR4 and TLR9) (28) and different cancers have been identified (29–34), there is no study in the literature that evaluate the effects of NOB on TLR3 signaling pathway in PCa In Vitro. For this reason, we aimed to evaluate the effects of NOB on the changes of gene and protein expression levels of TLR3 signaling pathways in PCa for the first time.
The pharmacokinetic study on the interaction between nobiletin and anemarsaponin BII in vivo and in vitro
Published in Pharmaceutical Biology, 2021
Jie Zhang, Meiling Fan, Xia Yu, Bin Zhang
Fever and cough are common paediatric diseases in the clinic, and traditional Chinese medicine is always considered as the main therapeutic strategy in China (Shih et al. 2016; Wang C et al. 2019). The combination of various herbs is the main trait of traditional Chinese medicine that could improve the curative effect and treat the complications. Due to similar indications, Anemarrhena asphodeloides Bunge (Asparagaceae) and Citrus reticulata Blanco (Rutaceae) might be used in the same prescription (Wang Y et al. 2014; Liu et al. 2016). Nobiletin is a kind of polymethoxyflavonoid extracted from the leaves or stem of C. reticulata. In previous studies, the pharmacological activities of nobiletin have been widely reported including anticancer, anti-inflammation, antioxidant, and neuroprotection (Kazak et al. 2021; Rong et al. 2021; Wang JG et al. 2021). Anemarsaponin BII is the major active ingredient of A. asphodeloides responsible for the pharmacological effects, such as anti-inflammatory, immune-stimulating, and treating paediatric fever, cough, and allergies (Kim et al. 2009; Zhao X et al. 2016).