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Monographs of fragrance chemicals and extracts that have caused contact allergy / allergic contact dermatitis
Published in Anton C. de Groot, Monographs in Contact Allergy, 2021
Nerolidol (any isomer) has been identified by chemical analysis in 65 of 91 essential oils, which have caused contact allergy / allergic contact dermatitis. In three oils, (E)-nerolidol belonged to the ‘Top-10’ of ingredients with the highest concentrations which may be expected in commercial essential oils of this type: niaouli oil (0.3–80.3%), neroli oil (1.7–4.9%) and cardamom oil (0.5–2.0%) (4). Nerolidol may also be present in Myroxylon pereirae resin (balsam of Peru) (2–7%) (1).
Central Nervous System Effects of Essential Oil Compounds
Published in K. Hüsnü Can Başer, Gerhard Buchbauer, Handbook of Essential Oils, 2020
Elaine Elisabetsky, Domingos S. Nunes
Nerolidol 10 showed protective effects in the rotenone-induced neurodegeneration model of PD (Javed et al., 2016). Rotenone induced a marked state of oxidative stress (reduced SOD, CAT, and GHS and increased MDA), neuroinflammation (increased proinflammatory cytokines IL-1β, IL-6, and TNF-α and mediators COX-2 and iNOS) in rat brain tissues. Consistently, increased activated astrocytes (GFAP), microglia (Iba-1) and loss of dopamine (DA) neurons in the substantia nigra pars compacta and dopaminergic nerve fibers in the striatum were observed. As expected from its well-documented antioxidant capacity, nerolidol increased the level of SOD, CAT, and GSH, and decreased that of MDA. Nerolidol also inhibited the release of proinflammatory cytokines and inflammatory mediators and prevented glial cell activation and the loss of dopaminergic neurons and nerve fibers. Overall, data suggest that nerolidol attenuates rotenone-induced dopaminergic neurodegeneration through its antioxidant and anti-inflammatory properties.
Therapeutics of Artemisia annua
Published in Tariq Aftab, M. Naeem, M. Masroor, A. Khan, Artemisia annua, 2017
Some other sesquiterpenes, like nerolidol (3,7,11-trimethyl-1,6,10- dodecatrien-3-ol), showed IC50 of 0.99 μmol/L and were able to arrest development of the intraerythrocytic stages of the Plasmodium (van Zyl et al., 2006). In a report that Indians of the Amazon basin in Brazil treated malaria using the vapors of the leaves of Viola surinamensis; where nerolidol was identified as the active constituent leading to 100% growth inhibition at the schizont stage (Lopes et al., 1999). A plant variety from Ethiopia showed high levels of nerolidol (Muzemil et al., 2008) and found more in the stem than in leaves (Li et al., 2011).
Oral delivery of nerolidol alleviates cyclophosphamide-induced renal inflammation, apoptosis, and fibrosis via modulation of NF-κB/cleaved caspase-3/TGF-β signaling molecules
Published in Drug Delivery, 2023
Ashif Iqubal, Abul Kalam Najmi, Shadab Md, Huda Mohammed Alkreathy, Javed Ali, Mansoor Ali Syed, Syed Ehtaishamul Haque
The outcome of the present study showed the potent renal protective potency of nerolidol against cyclophosphamide-induced renal toxicity. We found that administration of a single dose of cyclophosphamide 200 mg/kg, p.o induced renal toxicity via oxidative stress, inflammation, apoptosis, fibrosis, and histopathological aberrations. In the in vivo study, when Nerolidol was used at the dose of 400 mg/kg, a potent antioxidant, anti-inflammatory, anti-apoptotic, and antifibrotic effect via increased activity and level of SOD, CAT, GSH, and reduced level of MDA was observed. Nerolidol 400 mg/kg also reduced the expression of -κB, cleaved caspase-3, and Smad3 along the level of TNF-α, IL-6, Il-1β, kidney injury markers, TGF-β1, and other fibrotic markers. In the in vitro study, nerolidol at the 50 µM reduced the expression of NF-κB, caspase-3, and TGF-β1. However, no significant renal protection was exhibited by the lower dose of nerolidol in the in vivo (200 mg/kg, p.o) as well as in vitro study (25 µM). This ineffectiveness could be due to lower doses and pharmacokinetic limitations such as low bioavailability and low solubility, resulting in inferior therapeutic outcomes. We further conclude that the estimation of p-Smad2/3, mitochondrial ROS, and redox signaling pathways should be explored, and it can be considered a limitation of this study. Furthermore, more detailed cellular and molecular studies are needed to use nerolidol as an adjuvant among patients treated with chemotherapeutic drugs.
GC-MS Profiling and Antineoplastic Activity of Pelargonium Inquinans Ait Leaves on Acute Leukaemia Cell Lines U937 and Jurkat
Published in Nutrition and Cancer, 2022
Ogochukwu Izuegbuna, Gloria A. Otunola, Graeme Bradley
The treatment of the RAW 264.7 cells with Pelargonium inquinans extracts caused a decrease in COX-2 expression by most of the extracts The fresh acetone extract and the acetone dried extract showed more anti- COX-2 inhibition than celecoxib and were of almost equal inhibition strength with aminoguanidine (Figure 5). The Pelargonium spp are known to have anti-inflammatory properties. Crude extracts of Pelargonium graveolens have recently been shown to inhibit prostaglandins and thromboxanes- end products of the COX-2 pathway -production in RAW 264.7 cell culture44. A nanoemulsion containing geranium oil in macrophages was shown to inhibit COX-2 gene expression as well as other inflammatory mediators45. The essential oils of Pelargonium spp are famed for their soothing and anti-inflammatory effects46. Eugenol, a phenylpropene also detected in our study is known to inhibit COX-2 expression in RAW 264.7 cells47. Nerolidol, a sesquiterpene alcohol also discovered in this study and widely used in the food and cosmetics industry is reported to have both anti-nociceptive and anti-inflammatory activity48. Pelargonium inquinans from our study has shown it has dual anti-inflammatory and pro-inflammatory properties.
The beneficial effects of nerolidol and hesperidin on surgically induced endometriosis in a rat model*
Published in Gynecological Endocrinology, 2018
Rauf Melekoglu, Osman Ciftci, Sevil Eraslan, Aslı Cetin, Nese Basak
The primary role of free radicals, as signaling molecules mediated by proinflammatory cytokines, in the pathophysiology of endometriosis has been demonstrated [5,6]. Hesperidin is a bioflavonoid that is found in Citrus species such as orange and lemon. Nerolidol is a naturally occurring sesquiterpene alcohol that is present in the essential oils of numerous plants with a floral odor. The antioxidant, radical scavenging, and anti-inflammatory effects of hesperidin and nerolidol have been demonstrated in several studies, but no studies have investigated the effects of hesperidin or nerolidol on endometriosis [7,8].