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Sensing of Magnetic Nanoparticles for Sentinel Lymph Nodes Biopsy
Published in Shoogo Ueno, Bioimaging, 2020
Masaki Sekino, Moriaki Kusakabe
Figure 8.3(b) outlines the principle of the magnetic probe we developed [20–23]. For this device, a Hall effect sensor was attached to the tip of a brass pipe, and the sensor was combined with a ring-shaped neodymium magnet. The magnetic field is 0 at a point on the axis of the ring-shaped neodymium magnet so the Hall effect sensor is aligned to that position. Unless magnetic bodies enter in the area ahead of the sensor, it does normally not detect any magnetic field. In actual measurements, magnetic nanoparticles are searched using the magnetic probe and if the magnetic nanoparticles are present in the detection area ahead of the probe head, these are magnetized by the magnetic field of the neodymium magnet (Figure 8.3(c)). Then, a magnetic field is formed from the nanoparticles and it is detected by the Hall effect sensor.
Special Problems of Internal Radioactive Materials
Published in George W. Casarett, Radiation Histopathology, 2019
The rare earth elements (57 to 71) include lanthanum, cerium, praeseodymium, neodymium, promethium, samarium, europium, gadolinium, terbium, dysprosium, holmium, erbium, thulium, ytterbium and lutetium. Yttrium and these 15 rare earth elements behave similarly chemically, but their numerous isotopes present a broad spectrum of different radiation characteristics. The absorption of these elements from the gastrointestinal tract and lung is insignificant.
European Clinical Experience In Laser Photocoagula Tion In Upper Gastrointestinal Tract
Published in John P. Papp, Endoscopie Control of Gastrointestinal Hemorrhage, 2019
More than 1000 patients have now been treated in Europe. The majority were treated with Neodymium-Yag lasers in uncontrolled studies. The results are summarized in Tables 3 to 8. While giving interesting information, the data do not permit firm conclusions. Techniques, definitions, indications for surgery, and particularly the selection of patients for endoscopic treatment, all differ between centers.
Chidamide stacked in magnetic polypyrrole nano-composites counter thermotolerance and metastasis for visualized cancer photothermal therapy
Published in Drug Delivery, 2022
Sizhen Wang, Zhiqiang Ma, Zhang Shi, Ying Huang, Tianheng Chen, Lei Hou, Tao Jiang, Feng Yang
Magnetic targeting of CMPP in vivo was verified by MRI and images were compared between pre- and post-injection with/without the intervention of magnetic field for 40 min in each group. Neodymium-iron-boron magnet was used to simulate the magnetic field effect at the tumor site during the experiment, resulting in non-solid melanoma malformation as the figures showed (Figure 5(A)). The signal intensity of tumor sites in mice with/without magnetic field intervention significantly different. Briefly, the relative signal intensities of all groups were increased, reflecting the T1 enhancement effect after injection for 40 min. Therein, the relative signal intensity of M + CMPP + group increased by 14.77 ± 4.63%, while that of CMPP + group only increased by 2.44 ± 1.52% (Figure 5(B)), denoting more CMPP could target to tumor sites under the intervention of external magnetic field. Here, because of its small enough particle size, CMPP exhibited T1 enhancement effect rather than T2 enhancement effect (Lu et al., 2017).
Poly-β-Cyclodextrin-coated neodymium-containing copper sulphide nanoparticles as an effective anticancer drug carrier
Published in Journal of Microencapsulation, 2022
Archana Sumohan Pillai, Aleyamma Alexander, Govindaraj Sri Varalakshmi, Varnitha Manikantan, Bose Allben Akash, Israel V. M. V. Enoch
The synthesis of β-CD polymer was accomplished with the method described by Koopmans and Ritter (2008). NdCuS2 covered poly-CD NPs were synthesised employing hydrothermal method. Copper chloride (0.01 M) and thiourea (0.03 M) were mixed in 20 mL of ultrapure water medium and stirred for 15 min. After 15 min, 10 mL of 0.02 M neodymium nitrate was added dropwise followed by the addition of 0.2 g of CTAB and 0.2 g of poly-CD. The combination was then added to 6: 4 TEA: ethyl acetate (10 mL). The subsequent mixture was subjected to sonication for 2 h at RT and afterward moved to a Teflon-lined alloy autoclave. The temperature was kept up with at 180 °C for one day. The poly-CD-covered NdCuS2 (P-NCS) nanoparticles obtained was washed with ultrapure water and spirit several times to eliminate unreacted compounds. The resulting nanoparticles were dried at RT.
Design and construction of a magnetic targeting pro-coagulant protein for embolic therapy of solid tumors
Published in Artificial Cells, Nanomedicine, and Biotechnology, 2020
Mingyuan Zou, Peilan Xu, Li Wang, Lanlan Wang, Tingting Li, Cong Liu, Lei Shi, Jun Xie, Wanyun Li, Shengyu Wang, Guoqiu Wu, Fanghong Luo, Ting Wu, Jianghua Yan
Living imaging system was used to assay magnetic targeting ability of the MTPCP in vivo. Magnetic targeting ability means that the MTPCP can be enriched in tumour vessels by applying extra magnetic field on tumour area after tail vein administration. As shown in Table 1, randomly divided 12 of HepG2 tumour bearing nude mice into 4 groups. The proteins on the tTF-EG3287 group and the MTPCP group were labelled with fluorescently Cy5.5. The ratio of the absorbance in a cuvette with a 1-cm pathlength at 650 nm (A650) and 280 nm (A280) used to calculate the F/P value. After administration, we placed a neodymium magnet on the cancer area of mice on the OCMC/Fe3O4 group and the MTPCP group for 30 min immediately. Living imaging system was performed at 30 min, 1 h, 2 h, 4 h, 6 h, 12 h, 24 h,48 h and 72 h after administration by Imaging IVIS-200 system (Caliper Life Sciences) to detect the distribution of drugs in vivo.