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Mitigation of Obesity: A Phytotherapeutic Approach
Published in Amit Baran Sharangi, K. V. Peter, Medicinal Plants, 2023
A.B. Sharangi, Suddhasuchi Das
Nelumbo nucifera is an aquatic plant, resembling the water lily with large flowers. It is usually known as Indian lotus, sacred lotus, bean of India, and belongs to the Nelumbonaceae family. To treat obesity in China, Nelumbo nucifera leaf extract is used. Anti-obesity effect of Nelumbo nucifera essentially involves inhibition of alpha-amylase and lipase activity and regulated lipid metabolism. It also accelerates the lipid metabolism by expression of UCP3 mRNA in C2C12 myotubes (Ono et al., 2006). Nelumbo nucifera leaf extract was found to prevent the increase in body weight, parametrial adipose tissues weight and liver triacylglycerol level (Kumar et al., 2011).
The Orient
Published in Michael J. O’Dowd, The History of Medications for Women, 2020
The lotus, Nelumbo nucifera, is a beautiful water plant associated with divinity. Lotus is from the Greek, lotos, while nelumbo is the Sinhalese name for the Holy Lotus. In Asia the lotus is a symbol of the yoni and is associated with the goddess Padma (Shakti) from whom it gains its Sanskrit name (Padma). The god Brahma was styled ‘Lotus-born’, as he arose from the primal goddess’s yoni. The Buddha first appeared floating on a lotus, with the soles of his feet resting on his thighs, a posture known in Yoga as the Lotus position. In China the custom of foot-binding evolved to produce artificially clubbed feet (known as golden lotuses). Maidens with golden lotus feet, a sign of great beauty, were deemed the most desirable for marriage.
Nelumbo nucifera
Published in Dilip Ghosh, Pulok K. Mukherjee, Natural Medicines, 2019
Pulok K. Mukherjee, Debayan Goswami, Bhaskar Das, Subhadip Banerjee
Nelumbo nucifera, also called the Indian lotus, is a giant aquatic herb with stout crawling chromatic white-coloured rhizomes that has primarily been used as food throughout the Asian continent, and its medicinal values are represented in Ayurvedic and traditional Chinese medicine.
Sleep-promoting activity of lotus (Nelumbo nucifera) rhizome water extract via GABAA receptors
Published in Pharmaceutical Biology, 2022
Yejin Ahn, Singeun Kim, Chunwoong Park, Jung Eun Kim, Hyung Joo Suh, Kyungae Jo
Our previous studies confirmed the sleep-promoting activity of Nelumbo nucifera Gaertn. (lotus) seed and leaf extracts (Jo et al. 2021b; Kim et al. 2021). Interestingly, γ-aminobutyric acid (GABA) present in lotus seeds was found to be the sleep-promoting compound that acted through the GABAA receptor. Similarly, quercetin-3-glucuronide in lotus leaf extract was found to increase sleep time and nonrapid eye movement (NREM) sleep by binding to the GABAA-benzodiazepine receptor. Lotus is a perennial aquatic plant that grows in ponds or swamps. In Asian countries, including Korea, China, Japan and Vietnam, all parts of the lotus, including flowers, rhizomes and leaves, are used as food. Along with the lotus leaf, the rhizome has the largest market as an edible food item; it is a common vegetable in China and is used in various dishes or even eaten raw (Yang et al. 2007). In particular, the rhizome has long been used as antipyretic, antidiabetic, hepatoprotective and anti-inflammatory in oriental medicine prescriptions (Mukherjee et al. 1997; Sridhar and Bhat 2007; Zhao et al. 2014). However, to date, the sleep-promoting activity of lotus rhizome (LE) has not been studied. This study investigated the sleep-promoting activity of LEs, which is the second most part consumed after its leaves.
Protective effects of lotus plumule ethanol extracts on bleomycin-induced pulmonary fibrosis in mice
Published in Drug and Chemical Toxicology, 2022
Peng Guo, Bin Li, Meng-Meng Liu, Yan-Xiao Li, Gong-Yu Weng, Ying Gao
The Chinese medicinal herbs were provided by Baixing Pharmaceutical Co., Ltd. (Tianjin, China) and identified as the dry young leaves and radical seeds of Nelumbo nucifera (Gaertn) by Professor Hong Chen of the Department of Pharmacy, Logistics College of Chinese People's Armed Police Force. The voucher specimen is deposited in our laboratory. The LPEs were prepared as follows: lotus plumule (100 g) was powdered and soaked in 1000 ml of 85% ethanol for 1 h at room temperature, and was then refluxed for 1 h. The filtrate was collected, and the residues were refluxed twice in 800 ml of 85% ethanol for 1 h. The combined filtrate was concentrated with a rotary evaporator at reduced pressure, vacuum-dried, and then the extract (LPs0206) was obtained at a yield of 10.06% (g/g). Finally, the extracts were dissolved in 0.9% saline for intragastric administration.
Wound healing activity of neferine in experimental diabetic rats through the inhibition of inflammatory cytokines and nrf-2 pathway
Published in Artificial Cells, Nanomedicine, and Biotechnology, 2020
Juan Li, Haiyan Chou, Lei Li, Hao Li, Zhengjun Cui
The Nelumbo nucifera (sacred lotus) is a traditional medicinal plant used throughout India and China primarily as a food and medicine. On the dietary aspect, all parts of the plant are all edible, demonstrating the non-toxic nature of it. Further, they are also medically applicable because they harbour a massive array of bioactive complexes. Flowers, leaves, seeds and fruit of the plant have been utilized traditionally to treat a wide range of conditions, comprising diarrhoea, abnormal bleeding, poor digestion, fever and insomnia. However, there is lack of not scientific research on the use of lotus to treatment of any this condition [5]. Neferine is a dibenzylisoquino-line alkaloid extracted from lotus seed. A previous study exerted significant efficacy antioxidant, antidepressant, anti-tumour and anti-inflammatory properties [6–8]. Collectively, these pharmacologic properties may provide a foundation to investigate the studies related to diabetic wound healing activity of neferine. Therefore, grounded on the existed evidence and understanding, the present study was subjected to scrutinize the protective role of neferine in wound healing activity in diabetic rat model.