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Chemopreventive Agents
Published in David E. Thurston, Ilona Pysz, Chemistry and Pharmacology of Anticancer Drugs, 2021
In humans, naringin has been shown to inhibit a number of drug-metabolizing cytochrome P450 enzymes including CYP1A2 and CYP3A4 which can lead to adverse reactions with other drugs. Furthermore, ingestion of naringin and related flavonoids can affect the intestinal absorption of some other drugs, leading to either increased or decreased plasma levels. Therefore, to avoid interference with drug absorption and metabolism, citrus fruits (especially grapefruit) and their juices are often contraindicated in patients taking certain prescription medications. In humans, after ingestion, naringin is metabolized to naringenin.
Role of Plant-Based Bioflavonoids in Combating Tuberculosis
Published in Megh R. Goyal, Durgesh Nandini Chauhan, Assessment of Medicinal Plants for Human Health, 2020
Alka Pawar, Yatendra Kumar Satija
Naringenin is a natural flavonoid that is mainly found in grapes, tomatoes, and oranges. It belongs to flavanone subclass and has anti-mycobacterial, anti-inflammatory and antioxidant activities. Several studies revealed the molecular mechanism related to beneficial activities of naringenin, however, the evidence is still lacking.2
Bioflavonoids
Published in Hafiz Ansar Rasul Suleria, Megh R. Goyal, Masood Sadiq Butt, Phytochemicals from Medicinal Plants, 2019
Muhammad Sajid Arshad, Urooj Khan, Ali Imran, Hafiz Ansar Rasul Suleria
The long-term consumption of flavanols-containing foods can lead to a sustained increase in endothelial function or prevention of future cardiovascular diseases.17 The antioxidant activity possessed by flavanones relies on the phenolic OH group number and their spatial location. The flavanones present in the hydrophilic environment show higher antioxidant activity.18 It is believed that flavanones have the potential to resist atherosclerosis. Studies have shown that due to the diminution of atherosclerosis in mice on a diet that was high in fat and cholesterol with the supplements of naringenin at nutrition-related levels. The results can be used to improve dyslipidemia and the dysfunction of endothelial biomarkers, with changes in the expression of the gene. The flavanones can thus prevent the risk of CVDs.23 Pentamethoxyflavone (PMF) was isolated from the rhizomes of Kaempferia parviflora, which has antihypertensive effects. This study has clearly shown that PMF has an endothelium-dependent and independent relaxation activity with isolated thoracic aortic rings. A research study was conducted to explore the possible mechanisms for relaxation in order to determine whether PMF acts (1) as a nitric oxide (NO) stimulant, guanylatecyclase, adenylatecyclase, or H2S stimulant and/or through an open K+ channel, (2) off the voltage-dependent calcium channel, (3) by inhibiting intracellular calcium mobilization, (4) as a calcium-channel inhibitor for storage operations, or (5) as a Rho-kinase inhibitor.89
Evaluation of the hepatoprotective effect of naringenin loaded nanoparticles against acetaminophen overdose toxicity
Published in Drug Delivery, 2022
Ruijie Lu, Run-Jie Yu, Chunhui Yang, Qian Wang, Yunxia Xuan, Zeqing Wang, Zhimin He, Yan Xu, Longfa Kou, Ying-Zheng Zhao, Qing Yao, Shi-Hao Xu
Naringenin possesses powerful anti-inflammatory and antioxidant properties and has therapeutic potential in both inflammatory related diseases and oxidative stress-induced diseases. However, naringenin has limited its application in the medical field due to its poor water solubility and low bioavailability. Therefore, in this study, we designed bovine serum albumin-based naringenin nanoparticles (NGNPs), which could increase liver accumulation by the mononuclear phagocyte system and continuously reach effective concentrations. The constructed NGNPs significantly enhanced the resistance of liver cells to excessive oxidative stress and proinflammatory stimulation. Meanwhile, NGNPs significantly alleviated the disease progression of ALI and inhibited liver cell apoptosis in ALI mouse models. In conclusion, naringenin nanoparticles with a simple preparation method have great potential in treating ALI.
Naringenin Suppresses Chemically Induced Skin Cancer in Two-Stage Skin Carcinogenesis Mouse Model
Published in Nutrition and Cancer, 2020
The naringenin [IUPAC name – 5,7 dihydroxy-2-(hydroxyphenyl)chroman-4-one (CAS No. 480-41-1)], a phytochemical present in citrus fruits as a glycoside conjugate has diverse medicinal properties. Naringenin is present in citrus fruits (grape fruits, oranges) as well as tomatoes (skin). However, grapefruit juice yields highest levels of naringenin in plasma (3). The flavanone naringenin is known to exhibit many pharmacological properties. It is a natural antioxidant and shows anti-inflammatory and immunomodulatory activity (4). Anti-cancer activity of naringenin has been reported against a number of cancer cell lines, i.e. stomach (KATOIII, MKN-7), and colon (Caco-2), liver (HepG2, Hep3B, Huh7), breast (MCF-7, MDA-MB-231), leukemia (HL-60, NALM-6, Jurkat, U937), cervix (Hela, Hela-TG) and pancreas (PK-1) (5). Naringenin can block cell cycle and induces apoptosis by modulating the expression of Bax and p53 (6). Besides it has been reported to protect against oxidative stress and inflammation and inhibit the release of inflammatory cytokines from the macrophages via down regulation of AP-1 (7, 8).
Naringenin prevents doxorubicin-induced toxicity in kidney tissues by regulating the oxidative and inflammatory insult in Wistar rats
Published in Archives of Physiology and Biochemistry, 2020
Tajdar Husain Khan, Majid Ahmad Ganaie, Khalid Mofleh Alharthy, Hassan Madkhali, Basit Latief Jan, Ishfaq Ahmad Sheikh
Evidence-based studies suggest that a simultaneous treatment of anticancer drugs with natural chemopreventive agents having antioxidant action may augment the efficacy of chemotherapeutics (Lee et al.2008, Aydin et al.2011). Numerous phytochemicals with chemosensitising ability and anticancer properties have been tested in different in vivo and in vitro models (Khan et al.2012a, 2012b, Rehman et al.2012, 2013, Mohajeri and Sahebkar 2018). Naringenin (4,5,7-trihydroxyflavone), is naturally occurring flavanone, principally present in citrus fruits and in ample quantities found in cherries, grapefruits, and tomatoes (Kawaii et al. 1999). On the scale of the relative toxicity of chemicals naringenin, is reported to be a harmless phytochemical substance. Moreover, it is shown to be tolerated even up to levels 100 mM without causing any toxicity (Surampalli et al.2016). Naringenin is known for its super antioxidant properties with wide number of pharmacological effects e.g. anti-diabetic hepatoprotective, anti-mutagenic, and anti-carcinogenic, anti-atherogenic (Francis et al.1998, Santos et al.1999, Ekambaram et al.2008, Goldwasser et al.2010, Renugadevi and Prabu 2010, Rayidi 2011, Bharti et al.2014, Rehman et al.2018a, 2018b).