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Bites and stings
Published in Biju Vasudevan, Rajesh Verma, Dermatological Emergencies, 2019
Vesicating species [31–34] Family Meloidae (oil beetles, blister beetles): Lytta vesicatoria: Many species contain the irritant cantharidin which produces an irritant dermatitis and bullae when it comes in contact with the skin.Family Staphylinidae (rove beetles) [35–37]: Paederus dermatitis is an irritant contact dermatitis characterized by sudden onset of erythemato-bullous lesions on exposed areas of the body. The disease is caused by an insect belonging to the genus Paederus (Figure 54.3) [38–40].
Beetles
Published in Gail Miriam Moraru, Jerome Goddard, The Goddard Guide to Arthropods of Medical Importance, Seventh Edition, 2019
Gail Miriam Moraru, Jerome Goddard
The ash-gray beetle (Epicauta fabricii) and striped blister beetle (E. vittata) are common in the central and southeastern areas of the United States. Oil beetles and other large, rounded species are common in the southwestern United States from Texas to southern California. Many other blister beetle species are common in the western United States. In Europe, three important blister beetles are Paederus limnophilus, P. gemellus, and Lytta vesicatoria (the Spanish fly).
Traditional Chinese Medicine in Oncotherapy: The Research Status
Published in Nutrition and Cancer, 2020
Huijuan Tang, Peng Shu, Shenlin Liu, Xu Zhang, Monica Mattioli-Belmonte
Even when the effects of chemotherapy and radiation are significant, many patients will lose their lives due to recurrence and metastasis. Research has found that geranyl lignin (from the Citrus limon) through matrix metalloproteinase (MMP) pathway could inhibit the expression of MMP-2 and MMP-9 protein levels and reduce the hydrolysis of the extracellular matrix, and the extracellular matrix has powerful resistance to invasion and metastasis in liver cancer (46). FAM46C plays a critical role in migration and invasion of hepatocellular carcinoma cells via TGF-β/Smad signaling. Norcantharidin (a cantharidin derivative, from Lytta vesicatoria) could antimetastatic by upregulating FAM46C expression and regulating TGF-β/Smads signaling pathway which prevents the expression of EMT-related transcription factors (47). Berberine (from Coptis chinensis) can significantly inhibit the extracorporeal and internal migration of HCT-116 cells in CRC by regulating the Ras-ERK signaling pathway (48).
A comparative study of topical cantharidin and intralesional PPD to treat molluscum contagiosum
Published in Journal of Dermatological Treatment, 2020
Fathia M. Khattab, Mohamed M. Nasr
Cantharidine, a topical vesicant extracted from blister beetle (Lytta vesicatoria), is a frequently used therapy for MC (5,6). Its action mechanism includes the activation or release of epidermal serine proteases leading to tonofilament detachment, which causes intraepidermal blistering and inflammation, promoting the shedding of infected keratinocyte and viral clearing. MC (7,8).