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Immunocytochemical Detection Systems
Published in Lars-Inge Larsson, Immunocytochemistry: Theory and Practice, 2020
Consequently, the Lugol’s iodine treatment is not a necessary prerequisite to immunogold-silver staining. It should be used routinely only with tissues fixed in sublimate-containing solutions. In material fixed otherwise, it may, in a few cases, have an unmasking effect on antigenicity, as evidenced by all immunocytochemical procedures. Therefore, comparisons between, e.g., immunogold-silver staining incorporating the Lugol’s iodine step, and PAP staining not incorporating this step may be misleading with some antigens. Conversely, the pretreatment could in other cases lead to destruction of some epitopes. If used, this part of the protocol, therefore should include appropriate noniodine controls.
Benign Thyroid Disease
Published in John C Watkinson, Raymond W Clarke, Louise Jayne Clark, Adam J Donne, R James A England, Hisham M Mehanna, Gerald William McGarry, Sean Carrie, Basic Sciences Endocrine Surgery Rhinology, 2018
Christopher M. Jones, Kristien Boelaert
Lugol’s iodine had traditionally been used in patients awaiting surgery in an effort to reduce iodide uptake and therefore inhibit thyroid hormone release, as well as reducing the vascularity of the thyroid gland. It is now avoided due both to the unpredictable response to its administration and to its potential for exacerbating, rather than improving, thyrotoxicosis.
Classifications
Published in Fazal-I-Akbar Danish, Ahmed Ehsan Rabbani, Pharmacology in 7 Days for Medical Students, 2018
Fazal-I-Akbar Danish, Ahmed Ehsan Rabbani
IodidesLugol’s iodinePotassium iodide
Hemodynamic Instability during Thyroidectomy in Graves’ Disease
Published in Journal of Investigative Surgery, 2022
Sami Acar, Candas Ercetin, Nuri Alper Sahbaz, Fırat Tutal, Yunus Yapalak, Fulya Cosan, Yesim Erbil
The patients were analyzed for their demographics, duration of the disease (period of medical treatment), history of smoking, presence of ophthalmopathy, choice of medication, preoperative need for plasmapheresis or use of Lugol’s iodine solution, weight of the resected specimen, TRAb values, type of surgery, and hemodynamic instability patterns. The patients were diagnosed with goiter disease by evaluating palpable diffuse goiter on physical examination, clinical signs of thyrotoxicosis, laboratory results, and results of diffuse radioactive iodine uptake in thyroid tissue on scintigraphy. The included patients also had at least one of the following conditions: ophthalmopathy in a physical examination, antithyroglobulin (antiTg) antibodies, TRAb, and/or positive anti-thyroid peroxidase (antiTPO) in blood tests.
Association between sedation and small neoplasm detection during diagnostic esophagogastroduodenoscopy: a propensity score-matched retrospective study
Published in Scandinavian Journal of Gastroenterology, 2022
Hao Wu, Lei Xin, Jin-Huan Lin, Qing-Hua Wang, Bo Li, Zhen-Dong Jin, Liang-Hao Hu, Wen-Bin Zou, Ke Qi, Ting Yang, Zhao-Shen Li, Zhuan Liao
EGD was performed to examine the upper GI tract carefully, including the esophagus, stomach and proximal duodenum. Mucus and foam remaining in the GI tract were flushed out with water containing dimethicone to obtain a better field of vision. White light endoscopy was the first method for detecting abnormalities of the GI tract mucosa. Advanced imaging techniques with Lugol’s iodine, indigo carmine, magnification, narrow-band imaging might be used to recognize the lesions. For mucosal lesions suspected to be neoplasms, biopsies were taken after exclusion of contraindications. The biopsy specimens were evaluated by pathologists at our hospital according to the WHO classification of digestive tumors [19].
Composition and consistence of the bacterial microbiome in upper, middle and lower esophagus before and after Lugol’s iodine staining in the esophagus cancer screening
Published in Scandinavian Journal of Gastroenterology, 2020
Jian Yin, Li Dong, Jing Zhao, Hairui Wang, Juxiao Li, Aisong Yu, Wen Chen, Wenqiang Wei
Plentiful studies showed that LIS chromoendoscopy is an effective way to boost the detection of esophageal diseases [31], especially precancerous lesions and cancer [32]. Moreover, the Lugol’s iodine (1.2%) solution is often used as a medication and disinfectant for numerous purposes. But it is unknown whether the solution affects the identification of bacteria with 16s rRNA gene sequencing. Therefore, we further analyzed the microbiome of esophagus after LIS compared with prior to LIS.