Isopropamide

Isopropamide

Nutritional and Dietary Supplementation during Pregnancy

Published in “Bert” Bertis Britt Little, Drugs and Pregnancy, 2022

This agent is used as an adjunct to treat ulcer disease and is used for the treatment of spastic bowel disorders. Congenital anomalies were not increased in frequency in the offspring of 180 women who took the drug during early pregnancy (Heinonen et al., 1977). No published animal teratology studies are available regarding isopropamide.

Atypical dyskinesias under treatment with antipsychotic drugs: Report from the AMSP multicenter drug safety project

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Journal Information

Published in The World Journal of Biological Psychiatry, 2022

Jessica Baumgärtner, Renate Grohmann, Stefan Bleich, Catherine Glocker, Johanna Seifert, Sermin Toto, Eckart Rüther, Rolf R. Engel, Susanne Stübner

In our study, AD-like AtypDs occurred on average after 80.2 days and TD-like AtypDs on average after 23.5 days. Reports of AD occurring late and TD occurring early in the course of treatment are rare. Chouinard and Jones (1979) reported an early onset of TD in a 23-year-old man suffering from undifferentiated schizophrenia. The patient developed slow lateral torsion movements of the tongue, with frequent partial protrusion and occasional complete protrusion 28 days after starting chlorpromazine (max. 300 mg/d) and 14 days after starting procyclidine, an anticholinergic drug used for the treatment of drug-induced EPS. Another case report by Chouinard et al (1982) presented the case of a 58-year-old non-psychiatric patient who developed severe and disabling TD seven weeks after taking a combination of isopropamide (an anticholinergic drug) and trifluoperazine (a phenothiazine APD) for four months due to a gastrointestinal disorder.

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Nutritional and Dietary Supplementation during Pregnancy

Atypical dyskinesias under treatment with antipsychotic drugs: Report from the AMSP multicenter drug safety project