China
Africa
Explore chapters and articles related to this topic
Recent Developments in Therapies and Strategies Against COVID-19
Published in Hanadi Talal Ahmedah, Muhammad Riaz, Sagheer Ahmed, Marius Alexandru Moga, The Covid-19 Pandemic, 2023
Misbah Hameed, M. Zia-Ul-Haq, Marius Moga
Indometacin is also one of the important NSAIDS which is usually recommended for the treatment of fever, pain, swelling, and inflammation and commonly prescribed in gout and arthritis. It inhibits the production of prostaglandins and also inhibits COX enzyme which is involved in the production of prostaglandins.
Diagnosis and Management of Facial Pain
Published in R James A England, Eamon Shamil, Rajeev Mathew, Manohar Bance, Pavol Surda, Jemy Jose, Omar Hilmi, Adam J Donne, Scott-Brown's Essential Otorhinolaryngology, 2022
Caroline P. Smith, Tim Woolford, Rajiv K. Bhalla
A severe debilitating unilateral headache affecting the peri-orbital and frontotemporal regions, with an average age of onset of 30 to 40 years. Attacks are short-lasting, ranging from 2 to 45 minutes and frequent, happening more than 5 times a day. Trigeminal autonomic symptoms may occur. Most patients respond to indomethacin within 24 hours. Other treatments include calcium-channel blockers, naproxen, carbamazepine, and sumatriptan.
Analgesics during Pregnancy
Published in “Bert” Bertis Britt Little, Drugs and Pregnancy, 2022
Indomethacin is used for analgesic, and anti-inflammatory effects in the treatment of rheumatoid arthritis, osteoarthritis, bursitis, and tendonitis. Because of it prostaglandin inhibition, has been used to treat premature labor in the second and third trimesters of pregnancy (Niebyl et al., 1980; Sibony et al., 1994; Zuckerman et al., 1974, 1984). Intravenous indomethacin was used to close a hemodynamically significant patent ductus arteriosus in premature infants. It was also used treat symptomatic leiomyomata during pregnancy (Dildy et al., 1992).
Tolerability of pharmacological agents in the treatment of headache following brain injury: a scoping review
Published in Brain Injury, 2023
Heather M. MacKenzie, Michael Robinson, Amanda McIntyre
Two case reports (level 5 evidence) and one case series (level 4 evidence) (13,15,16) (n = 6) described the use of indomethacin for PTH. One case report (16) focused on an individual with chronic paroxysmal hemicrania, whereas the other two articles (13,15) involved individuals with hemicrania continua. The treatment dose of indomethacin ranged from 100 mg to 300 mg daily. Five out of six of the subjects experienced gastrointestinal upset/nausea as a side effect of indomethacin, including one individual who developed colitis; two of these individuals discontinued indomethacin due to this side effect. Of these five subjects, three required the addition of another pharmacological agent to counteract the gastrointestinal upset, specifically a proton pump inhibitor, misoprostol or famotidine. Of note, the sixth subject, who did not specifically report any gastrointestinal symptoms, was simultaneously prescribed misoprostol, which counteracts gastrointestinal inflammation. The subjects (n = 4) described by Lay et al. (13) reported that their headaches were “significantly better” or “significantly lessened” with indomethacin treatment. Evans et al. (15) described a reduction in headache frequency from daily to every other day; of note, this individual was concurrently treated with amitriptyline 25 mg at bedtime, but no tolerability information was provided for this medication. The subject in the article by Jacob et al. (16) reported a complete resolution of his headaches.
Thymol Reduces Hepatorenal Oxidative Stress, Inflammation and Caspase-3#xd; Activation in Rats Exposed to Indomethacin
Published in Egyptian Journal of Basic and Applied Sciences, 2022
Tijani Abiola Stephanie, Olori O. David, Ebenezer O. Farombi
Drug-induced multi-organ toxicities are common adverse reaction triggered by numerous drugs like indomethacin (IND). Indomethacin is one of the non-steroidal anti-inflammatory drugs used as analgesic and also has antipyretic property. However, its adverse side effects have raised a lot of concern for its continuous use in clinical settings. Indomethacin cause many organ toxicities including liver, kidney and gastrointestinal toxicities in humans and experimental animals [1,2]. In the liver, IND has been associated with hepatocellular enzymes elevation and cholestatic jaundice whereas in the kidney, IND caused acute interstitial nephritis typified by wide spread interstitial edema with infiltration of inflammatory cells [3,4]. The mechanisms by which IND causes its toxicities include prostaglandin synthesis inhibition, generation of reactive oxygen species (ROS) resulting to cellular oxidative stress, inflammation and apoptosis [5].
What’s new on the front-line of gout pharmacotherapy?
Published in Expert Opinion on Pharmacotherapy, 2022
Kurt E. G. Blake, Jordan L. Saag, Kenneth G Saag
Glucocorticoids constitute another option for the treatment of gout flares. Glucocorticoids reduce inflammation by directly affecting gene transcription, repressing inflammatory genes, and enhancing the expression of anti-inflammatory genes [23]. The 2020 American College of Rheumatology guidelines places a high recommendation on the use of these medications, showing greatest efficacy when administered in the early stages of the flare [19]. Intraarticular glucocorticoid injections also represents a significant benefit over other acute flare medications when oral dosing is not an option and results in less systemic toxicity [19]. Additionally, glucocorticoids provide an alternative for patients with comorbidities where NSAIDs and/or colchicine are contraindicated. Among acute gout patients, oral prednisone, and indomethacin had similar analgesic capabilities. However, indomethacin was associated with more minor adverse events [24]. A meta-analysis of six randomized controlled trials (RCTs) with 817 total patients found no statistically significant difference in effective pain relief among NSAIDs and glucocorticoids within 7 days but were associated with more adverse GI events like nausea, vomiting, and indigestion [25]. Glucocorticoids can be used as a front-line pain management treatment for acute gout flares.