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Mitigation of Obesity: A Phytotherapeutic Approach
Published in Amit Baran Sharangi, K. V. Peter, Medicinal Plants, 2023
A.B. Sharangi, Suddhasuchi Das
St John’s wort (Hypericum perforatum L.) is an herbaceous perennial plant, native to Europe and Asia, and afterwards introduced into America. Compounds with biological activity for H. perforatum includes hyperforin, hypericin, flavonoids (kaempferol, quercetin, luteolin, isoquercitrin, quercitrin, rutin, among others), and condensed tannins (proanthocyanidins) are also present (Nahrstedt and Butterweck, 1997). Several studies report that H. perforatum has anti-obesity activity. Hernández-Saavedra et al. (2013) established that body weight gain was prevented (8%) in obese rats fed with fructose and high saturated fat diet by H. perforatum infusion treatment for 12 weeks.
Herbs with Antidepressant Effects
Published in Scott Mendelson, Herbal Treatment of Major Depression, 2019
Hypericum perforatum, widely known as St John’s wort, is an herbaceous perennial plant native to Europe and Asia. It has been introduced into the United States where it has naturalized.1 It has been used widely in both Chinese and Western herbal medicine. In Chinese it is Guan Ye Lian Qiao and, along with Siberian ginseng, it is an ingredient in the Chinese herbal treatment for depression Shuganjieyu. It was also known by Hippocrates and recommended by the great ancient Greek herbalist, Dioscorides.
Herbal Drug Development: Challenges and Opportunities
Published in Megh R. Goyal, Durgesh Nandini Chauhan, Plant- and Marine-Based Phytochemicals for Human Health, 2018
Bhagyashree Kamble, Neelam Athawale, Anand Gugale, Ashika Advankar, Ashwini Ghagare, Shankar Katekhaye, Abhishek Kulkarni, Priyanka Kanukuntla
Differential pulse polarography is used to study trace amount of chemicals with very small detection limits and some heavy metals such as cadmium, lead, zinc, copper, and iron. Content of total hypericin has been determined in Hypericum perforatum88 using this method.6, 57
Nanoencapsulation and characterisation of Hypericum perforatum for the treatment of neuropathic pain
Published in Journal of Microencapsulation, 2023
Radha Goel, Nitin Kumar, Neelam Singh, Rosaline Mishra
Hypericum perforatum L. (Hypericaceae), mainly known as St. John’s wort, is a perennial herb that has recently gained popularity as one of the world’s most commonly used medicinal plants (Birt et al.2009, Huang et al.2013). The extracts of Hypericum perforatum are employed as medical natural agents because they have a wide range of therapeutic actions, including antidepressant, antiinflammatory, antibacterial, antioxidant, wound healing, and pain relief (Güneş and Tıhmınlıoğlu 2017). It is regarded a safe herbal medicinal agent because it is well tolerated and has few negative effects (Woelk 2000). Recently, Hypericum perforatum has also been found to be useful in treatment of oxaliplatin-induced neuropathic pain (Cinci et al. 2017). One of the studies found that taking Hypericum perforatum extract (HPE) orally can improve morphine antinociception in conditions of neuropathic pain (Zeliou et al.2017). Hypericin is the major bioactive component for the most of HPE functional characteristics. As hypericin is sensitive to high temperatures and pH, it can be encapsulated to improve its stability (Greeson et al.2001).
Level of clinical evidence of herbal complementary therapies in psychiatric disorders
Published in Psychiatry and Clinical Psychopharmacology, 2019
Derya Ozsavci, Ozlem Bingol Ozakpinar, Mesut Cetin, Feyza Aricioglu
Hypericum perforatum L. (St John’s worth): H. perforatum, commonly known as St John’s wort (SJW), is a herbal remedy that has been used to treat emotional distress since the end of the 15th century. Hypericin (0.3–0.5%), hyperforin (3.0%) and various flavonoids are found in the content of the plant. In recent years, it is the first-line treatment option in the treatment of major depressive disorders in certain European countries. H. perforatum has an affinity for receptors of numerous neurochemical systems. In a comparative 27 clinical trials with 3808 depressive patients, St John’s wort and SSRI were compared and St John’s wort demonstrated comparable responses and remission rate like SSRIs with lower clinical side effects in ameliorating depressive symptoms [15]. Similarly, in another meta-analysis study H. perforatum was found as effective as SSRI in depressive cases and authors suggested that, these effects were limited as the treating time with extract (from 4–12 weeks period) and long-term efficacy and safety of Hypericum extract remain to be examined [16]. In a mechanistic study with 23 participants (13 patients and 10 controls with major depressive disorder), it has been emphasized that St John’s worth has no effect on MAO-A [17]. There are also other studies showing the effectiveness of H. perforatum in the treatment of obsessive compulsive disorder, social anxiety disorder and anxiety [16,18,19].
Evaluation of the antidepressant- and anxiolytic-like effects of a hydrophilic extract from the green seaweed Ulva sp. in rats
Published in Nutritional Neuroscience, 2018
Nicolas Violle, Pascale Rozan, Hervé Demais, Pi Nyvall Collen, Jean-François Bisson
Mood disorders are a major public health concern. Worldwide lifetime prevalence rates of anxiety disorders are estimated from 14 to 28% depending on methodologies and countries,26,27 while clinical depression rates are estimated from 3 to 17%.28 Antidepressant and anxiolytic medications are frequently prescribed but unfortunately exert negative side effects. While antidepressants can induce hepatotoxicity, pulmonary hypertension, headache, dizziness, drowsiness, dry mouth, nervousness, anxiety, insomnia, decreased appetite, and sexual disorders,29–31 benzodiazepines, the most prescribed class of anxiolytic, are also sedative/hypnotic, amnestic, anticonvulsant, muscle relaxant, and induce tolerance and dependence.32 Thus, it is important to find better drugs to address mood disorders with as few side effects as possible. Many plants display psychotropic effects in animals and humans, such as Hypericum perforatum for major depression and Piper methysticum for anxiety disorders, and may represent a good adjunct or alternative to existing antidepressant and anxiolytic therapeutics.33–36