China
Africa
Explore chapters and articles related to this topic
Cardiovascular Disease in Women
Published in Stephen T. Sinatra, Mark C. Houston, Nutritional and Integrative Strategies in Cardiovascular Medicine, 2022
Stephen T. Sinatra, Sara Gottfried
Our metabolic cardiology recommendations for women include the following targeted nutritional supplement program for PAD support: A high-quality multimineral/vitamin formula.A total of 100–300 mg of CoQ10 and 200–600 mg of magnesium, both of which help to lower blood pressure and support endothelial function.A total of 1–2 g of L-carnitine or 2 g of glycine propionyl L-carnitine (GPLC), a proprietary form of L-carnitine. L-carnitine helps clear our metabolic wastes that aggravate vasoconstriction in small blood vessels generated by cellular energy production. Cellular efficiency and aerobic capacity are supported when toxic by-products or the β-oxidation of fats is shuttled out of the mitochondria. GPLC does the same and also helps to improve blood flow by boosting nitric oxide, a biochemical that keeps blood vessels relaxed.A total of 5 g D-ribose, three times daily and prior to exercise activities.A total of 1–2 g omega-3 fatty acid (fish or squid oil).
Chalcone (1,3-Diphenyl-2-Propene-1-One) Scaffold Bearing Natural Compounds as Nitric Oxide Inhibitors: Promising Antiedema Agents
Published in Debarshi Kar Mahapatra, Cristóbal Noé Aguilar, A. K. Haghi, Applied Pharmaceutical Practice and Nutraceuticals, 2021
Debarshi Kar Mahapatra, Sanjay Kumar Bharti, Vivek Asati
It has recently observed that overexpression of this component leads to precipitation of both acute inflammation and chronic inflammation in tissues.11 For the treatment of such conditions, few natural and synthetic inhibitors have been identified so far which acts as a potent NO production inhibitor by directly modulating the three isoforms.12 The mediators of the immune system, the macrophages play a critical role in the defense system against various foreign agents and results in the production of NO.13 The loss of macrophage activity is found to be associated with cellular activation after treating with endotoxins.14 The major component of bacterial (gram-negative bacteria) cell walls, lipopolysaccharide (LPS) aggravates the proinflammatory cytokine production by swiftly activating the macrophages.15 LPS-stimulated NO synthesis has been perceived to enhance the apoptotic process.16 Glycine propionyl-L-carnitine, a well known dietary supplement has been recently observed clinically in amplifying the levels of NO.17 NO enhances the Ca2+ channel currents by stimulating the guanylate cyclase component present in photoreceptor rod cells.18 Inhibition of NO in LPS-stimulated cells is considered to be an attractive target in the management of chronic inflammation, platelet count, and thrombosis.19
Glycine
Published in Linda M. Castell, Samantha J. Stear (Nottingham), Louise M. Burke, Nutritional Supplements in Sport, Exercise and Health, 2015
There is little research on supplementation with glycine. Research which has been conducted has looked at its potential role in decreasing inflammation (Zhong et al., 2003). Sport-specific research has focused on combining glycine with other nutrients. Glycine-Propionyl-L-Carnitine (GPLC) has been shown to influence exercise performance (Smith et al., 2008b), decrease oxidative stress and potentially increase vasodilation through increases in plasma nitrate (Bloomer and Smith, 2009). Jacobs and Goldstein (2010) suggested that GPLC might enhance aerobic work capacity but that doses must be specific for exercise intensity and duration.
Development of phospholipon®90H complex nanocarrier with enhanced oral bioavailability and anti-inflammatory potential of genistein
Published in Drug Delivery, 2023
Vaishnavi S. Shete, Darshan R. Telange, Nilesh M. Mahajan, Anil M. Pethe, Debarshi K. Mahapatra
Albino Wister rats weighing 300–350 g were separated into two groups for in vivo pharmacokinetic investigations. Pure GEN (50 mg/kg, p.o.) and GPLC formulations (∼50 mg/kg, p.o.) were given orally to groups I and II, respectively. At 2, 4, 8, 16, and 32 h following oral delivery, the blood samples (0.5 mL) were obtained and put into the Eppendorf tubes.