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Ethnomedicinal and Pharmacological Importance of Glycyrrhiza glabra L
Published in Mahendra Rai, Shandesh Bhattarai, Chistiane M. Feitosa, Wild Plants, 2020
Ashish K. Bhattarai, Sanjaya M. Dixit
Some other active compounds in licorice extract, such as glabrene, Licochalcone A, Isoliquiritin are also responsible for inhibition of tyrosinase activity. Liquiritin present in licorice extract disperses melanin, thereby inducing skin lightening (Nohata et al. 2005).
Catalog of Herbs
Published in James A. Duke, Handbook of Medicinal Herbs, 2018
Glycyrrhiza contains saponin and tannic acids; the seeds contain typsin inhibitors and chymotrypsin inhibitors. G. glabra contains 2-beta-glucuronosyl glucuronic acid, glycyrrhizin, and isoliquiritigenin-4-glucoside. One analysis showed 20% moisture, 12 to 16% glycyrrhizin, 8% reducing sugars, 8% nonreducing sugars, 30% starch and gums, 5% ash, and 12 to 17% undetermined. Rose47 reports that licorice contains estrogenic materials. Glycyrrhizine is used in Egypt as a cortisone substitute, without the withdrawal syndrome of cortisone. Dry seeds contain 21 to 30% protein, 1 to 11% fat.21 Excessive licorice ingestion can lead to cardiac dysfunction and severe hypertension.11 According to Mitscher et al.,168licorice also contains glabndin, glabrene, glabrol (potent against Staphylococcus aureus, Mycobacterium smegmatts), formononetin, phaseollinisoflavone (phytoalexin), salicylic acid, o-acetyl salicylic acid (0.15%; perhaps enough to be pharmaceutical), and hispaglabridin (rather potent in vitro against Staphylococcus and Mycobacterium).
Screening of ninety herbal products of commercial interest as potential ingredients for phytocosmetics
Published in Journal of Enzyme Inhibition and Medicinal Chemistry, 2020
Mariacaterina Lianza, Manuela Mandrone, Ilaria Chiocchio, Paola Tomasi, Lorenzo Marincich, Ferruccio Poli
Among the active principles contained in RRO tyrosol and salidroside are known to posses Tyr IA activity20. Regarding GGL, it is traditionally and commercially used for skin whitening formulations. The pyranoisoflavan glabridin showed promising anti-tyrosinase activity on melanoma cells and anti-melanogenesis activity on B16 murine melanoma cells. Additionally, reduced pigmentation and inflammation induced by UVB on guinea-pig skins at 0.5% w/v concentration21. Licuraside, isoliquiritin and licochalcone A also showed competitive inhibition on monophenolase activity of mushroom tyrosinase22, conversely, glabrene and isoliquiritigenin can inhibit both the reactions catalysed by tyrosinase23.