China
Africa
Explore chapters and articles related to this topic
Prolactin and Uterine Adenomyose in Mice
Published in Nagasawa Hiroshi, Prolactin and Lesions in Breast, Uterus, and Prostate, 2020
Takao Mori, Hiroshi Nagasawa, Yasuhiko Ohta
In humans, treatments with gestagen or danazol are highly effective on the inhibition of the development of endometriosis.68 Some cases of endometriosis of humans are reported to improve symptomatically and objectively by the treatment with CB-154 alone or in combination with danazol.47,69,70 Furthermore, patients with advanced carcinoma of the uterine cervix, whose disease is considered terminal, are also reported to achieve remission by treatment with CB-154.71 All results lead us to again stress an important participation of PRL in the development and progression of these uterine lesions and suggest the possibility that temporary inhibition of pituitary PRL secretion may be efficient in prophylaxis of the lesions.
Uterine transplantation
Published in Carlos Simón, Linda C. Giudice, The Endometrial Factor, 2017
Nine live-donor UTx procedures were performed in Sweden in 2013 within a clinical trial (5). Eight recipients had the diagnosis of MRKH syndrome, and one recipient had undergone a radical hysterectomy in 2005 because of stage 1b cervical cancer. All recipients went through two or three IVF cycles prior to UTx in order to accumulate a substantial number of embryos to cryopreserve for use after UTx. The donors were mothers in five cases, one older sister, one maternal aunt, one mother-in-law, and one close friend. Importantly, the donors had normal pregnancies and no record of pre- or postterm delivery or repeated miscarriage. The five donors that were postmenopausal were put on cyclic estrogen–gestagen treatment for 2–3 months before surgery, in order to ensure a normal menstrual pattern. All donors and recipients were extensively investigated to ensure that there was no medical (5) or psychological (49) factor that could interfere with participation in the trial or the procedures.
The menstrual cycle and the skin
Published in Miranda A. Farage, Howard I. Maibach, The Vulva, 2017
Birgit Drexler, Michael Landthaler, Silvia Hohenleutner
More recent studies demonstrate that the combination of high estrogen and gestagen levels, such as is seen in the middle of the luteal phase, influences the vasodilatory system of the skin. Independently of the sympathetic innervation, local warming of the skin leads to vasodilation, which is presumably mediated by the formation of nitric oxide. This vasodilatory response to local thermal stimuli is intensified by high estrogen and gestagen levels. There seems to be no apparent effect of the active, adrenergically controlled vasoconstriction following cold application (19).
Regulatory aspects of myogenic factors GDF-8 and Follistatin on the intake of combined oral contraceptives
Published in Gynecological Endocrinology, 2020
Christoph Wallner, Annesophie Rausch, Marius Drysch, Mehran Dadras, Johannes Maximilian Wagner, Mustafa Becerikli, Marcus Lehnhardt, Björn Behr
Our study can serve as basis for further investigation of COC intake and muscle metabolism. Synthetic analoga of gestagen and estradiol might be a source for myogenic potential in the therapy of different diseases e,g. burn injuries with muscle cachexia where a recent study showed an orchestration between Myostatin and Follistatin in the development of the muscle loss. In this case the interplay of Testosterone, Follistatin and gestagens could synergisticly reduce the muscle loss due to protein degradation [18,25]. In some international guidelines for burn care the administration of Oxandrolone as selective Testosterone is already recommended [26]. An additional application might be the treatment of muscle cachexia in cancer patients as it has already been shown that gestagens can preserve muscle mass. Gestagens might constitute an additional option for the treatment of cachexia [27].
Induction of apoptosis by metformin and progesterone in estrogen-induced endometrial hyperplasia in rats: involvement of the bcl-2 family proteins
Published in Gynecological Endocrinology, 2018
E. Sahin, M. Eraslan Sahin, M. Dolanbay, B. Ozcelik, H. Akgun, C. Saatci
Apoptosis is programed cell death, and the Bcl-2 protein family is involved in this process. If the ratio of Bcl-2/Bax decreases, pores in the outer mitochondrial membrane release apoptogenic mitochondrial proteins for activating caspases and inducing apoptosis [22]. Thus, we aimed to evaluate the effect of metformin and progesterone on various pro or antiapoptotic proteins of the Bcl-2 family. It has previously been shown that progesterone activates the apoptotic cascade; Vereide et al. reported that proteins in this cascade are regulated by gestagen therapy in human EH [23]. Similarly, Choksuchat et al. reported that MPA significantly increased Bax and decreased Bcl-2 in human endometrial cells [24]. The data regarding the effect of metformin on apoptosis in cancer cells are not fully understood. Ben Sahra et al. reported that metformin did not induce apoptosis, but it blocked G0/G1 phase of the cell cycle in prostate cancer [25]. Similarly, Alimova et al. reported that breast cancer cells did not induce apoptosis after metformin treatment [26]. Conversely, Tokahashi et al. observed that metformin activated caspase-dependent apoptosis, and suppressed EC cell growth via cell cycle arrest [27]. In another study, Cantrell et al. reported that metformin-induced caspase-3 activation in EC cells in a dose-dependent manner [7].
Oestrogen therapy for postpartum depression: efficacy and adverse effects. A double-blind, randomized, placebo-controlled pilot study
Published in Nordic Journal of Psychiatry, 2022
Pirjo Kettunen, Eeva Koistinen, Jukka Hintikka, Antti Perheentupa
Gestagen may be needed in combination with oestrogen treatment because of possible vaginal bleeding or in order to prevent endometrial hyperplasia. According to a Cochrane systematic review [36], synthetic progestogens should be used with significant caution during the postpartum period because of the risk of developing PPD [39].