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Sinusitis (Acute)
Published in Charles Theisler, Adjuvant Medical Care, 2023
Gentian: Research studies show that taking gentian as part of a combination herbal product (containing 12 mg of gentian root and 36 mg each of European elder flower, verbena, sorrel, and cowslip flower) three times daily improves symptoms from sinus infections. Taking gentian as part of a combination herbal product along with a prescription steroid nasal spray (Nasonex) seems to reduce the symptoms of a sinus infection better than taking the steroid nasal spray alone.6
Catalog of Herbs
Published in James A. Duke, Handbook of Medicinal Herbs, 2018
Dried rhizomes are used medicinally as bitter tonic and a stomachic. Gentian is a folk remedy for cancers, carcinomas, tumors, and indurations of the liver and spleen.4 Gentian is used to stimulate gastric secretion, improve appetite and digestion, and alleviate debility. Reported to be anthelmintic, antiseptic, apertif, emmenagogue, febrifuge, stimulant, stomachic, and tonic, gentian shows up in folk remedies for: anorexia, blood disorders, cancer, cold, convulsions, debility, diarrhea, dogbite, dysmenorrhea, dyspepsia, fever, gastritis, gout, heartburn, inappetence, jaundice, malaria, oliguria, sideache, snakebite, splenitis, stitch, stomachache, syncope, and wounds.2,29,32,33,44 Parvati suggests that herpes is alleviated by application of gentian violet flowers.48
In vivo activity and atom pair fingerprint analysis of MMV665941 against the apicomplexan parasite Babesia microti, the causative agent of babesiosis in humans and rodents
Published in Pathogens and Global Health, 2023
Mohamed Abdo Rizk, Shimaa Abd El-Salam El-Sayed, Ikuo Igarashi
MMV665941 was also found to be effective against some strains of Perkinsus marinus, a major protozoal disease of oysters, however the efficiency was not uniform across all strains of the parasite [23]. Brugia malayi and B. pahangi, as well as Cryptosporidium, Tritrichomonas foetus trophozoites, and Trypanosoma cruzi, have all been proven to be susceptible to this chemical [24–27]. MMV665941 has a structural similarity to gentian violet. In addition to being utilized as a mold inhibitor in feed components, gentian violet has been employed in human medicine for illnesses with a variety of bacteria [28]. In the United States, however, gentian violet is strictly prohibited for use in any food animal [29]. Interestingly, there have been few grounds given for the gentian violet prohibition, other than the FDA’s statement that the impact of drug residues on human health has not been sufficiently studied [29].
Effect of intravaginal gentian violet for acute vaginal candidiasis treated with a single dose oral fluconazole: a randomised controlled trial
Published in Journal of Obstetrics and Gynaecology, 2022
Chenchit Chayachinda, Manopchai Thamkhantho, Popchai Ngamsakulrungroj, Charussri Leeyaphan, Orwan Tulyaprawat
Gentian violet (GV), which has anti-fungal, anti-helminthic and anti-bacterial activities, has been used to treat skin and mucosal fungal infection (Diehl 1996; Watson and Calabretto 2007). GV refrains Candida spp. from deoxyribonucleic acid (DNA) synthesis and function leading to cell lysis (Ying et al. 2010; Gomes-de-Elvas et al. 2012). In addition, GV can damage biofilm of Candida spp. (Traboulsi et al. 2011). Clinically, GV has comparable efficacy with nystatin for eradicating mucosal candidiasis in patients with human immunodeficiency virus (HIV) infection (Nyst et al. 1992; Mukherjee et al. 2017). The agent also showed excellent activity against fluconazole-resistant C. albicans which was found more common in VC than oropharyngeal candidiasis (Zhang et al. 2014). Furthermore, GV has extended duration of action (longer than 24 hours) intravaginally with a minimal inhibitory concentration (MIC) ranging from 0.125 to 4 μg/mL (Ying et al. 2010). Also, it is inexpensive and widely available in all levels of public health care settings in Thailand. Therefore, the present study aims to evaluate the additive effect of intra-vaginal GV on a single dose of oral fluconazole for treating women with acute VC.
Allogenic chondrocyte/osteoblast-loaded β-tricalcium phosphate bioceramic scaffolds for articular cartilage defect treatment
Published in Artificial Cells, Nanomedicine, and Biotechnology, 2019
Shuai Wu, Zhiguo Kai, Dong Wang, Lina Tao, Peng Zhang, Dawei Wang, Dongxing Liu, Shui Sun, Jian Zhong
The Beagles were anaesthetized and the wool on the interior of the knee joint was shaved. Then, the areas to be used for the surgeries were disinfected with tincture of iodine. The skin and subcutaneous fascia were incised. The knee joint was incised through the interior of kneecap. The kneecap tendon and quadriceps femoris tendon were stretched out. The kneecap was stretched to form dislocation and the femoral trochlea was exposed. Three cylinder-like articular cartilage defects with a diameter of about 0.45 cm and a depth of about 0.45 cm were constructed in the femoral trochlea. Chondrocyte/osteoblast-loaded β-TCP bioceramic scaffold, chondrocyte-loaded β-TCP bioceramic scaffold, β-TCP bioceramic scaffold were randomly implanted into these three defects of each femoral trochlea. Then, the kneecap was restored, knee capsule and muscular fascia tissue were sutured, and the skin incision was sutured. Gentian violet was spread on the skin incision. The Beagles were cultured at 15–20 °C and received intramuscular injection of penicillin 800,000 IU once a day in the first three days to prevent infection. The Beagles (3 of each group) were sacrificed at 12 weeks. The treatments in femoral trochlea were evaluated by both naked eyes/digital cameras and histology.