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Health Benefits of Musa Spp Species (Bananas) in Inflammatory Bowel Disease
Published in Megh R. Goyal, Preeti Birwal, Santosh K. Mishra, Phytochemicals and Medicinal Plants in Food Design, 2022
Ana Elisa V. Quaglio, Luiz Domingues de Almeida Junior, Luiz Claudio Di Stasi
The main phenol compounds reported include hydroxycinnamic and benzoic acids derivatives and heterosides such as ferulic, caffeic, sinapic, gallic, syringic, cinnamic, vannilic, tannic, chlorogenic, cumaric, and protocatechic acids (Figure 8.1); flavonoids such as rutin, quercetin glycosides, kaempeferol glycosides, isorhamnetin glycosides, and myricetin glycosides; tannins including catechin, epicatechin, gallocatechin (Figure 8.2). A detailed description of chemical composition in banana fruit pulp and banana fruit peel focusing antioxidant properties can be observed in the extensive review recently published [40, 56, 63].
Epigallocatechin-3-Gallate in Alzheimer’s Disease
Published in Atanu Bhattacharjee, Akula Ramakrishna, Magisetty Obulesu, Phytomedicine and Alzheimer’s Disease, 2020
Khaleel Pasha Md, Magisetty Obulesu
Of the many pharmacological studies conducted in attempts to combat AD, those on the green tea polyphenol EGCG, a vital polyphenol of green tea plant Camellia sinensis, have been of considerable importance (Schimidt et al., 2017; Cano et al., 2019). EGCG showed substantial antioxidant and chelating activities, due to the presence of two gallocatechol rings that scavenge free radicals effectively (Braicu et al., 2013; Cano et al., 2019).
Phytosomes as Useful Drug Delivery Systems for Cosmeceutical Application
Published in Madhu Gupta, Durgesh Nandini Chauhan, Vikas Sharma, Nagendra Singh Chauhan, Novel Drug Delivery Systems for Phytoconstituents, 2020
Francesca Froiio, Agnese Gagliardi, Massimo Fresta, Donato Cosco, Donatella Paolino
The flavonoids are polyphenolic compounds characterized by a chemical structure related to the 2-phenyl-benzo-γ-pyrone; they can be classified as flavones (i.e., luteolin), flavonols (i.e., rutin and quercetin), flavanols (i.e., catechin and gallocatechin), flavanones (i.e., naringin and hesperetin), isoflavones (i.e., daidzein and genistein), proanthocyanidins, and anthocyanins (i.e., cyaniding and pelargo-nidin).
Efficacy of topical epigallocatechin gallate (EGCG) 1% on the healing of chronic plantar ulcers in leprosy
Published in Journal of Dermatological Treatment, 2021
C. R. S. Prakoeswa, R. N. Oktaviyanti, D. M. Indramaya, E. Hendradri, S. Sawitri, L. Astari, D. Damayanti, M. Y. Listiawan
Difficult healing in leprosy ulcers has an impact on the social and economic lives of patients and their families (3,4). Epigallocatechin gallate (EGCG) is the most extract in green tea, and is the main source of bioactive green tea, has antioxidants that are far more powerful than vitamin C (5). EGCG is the largest component that covers 65% of the total catechins and is therapeutically active. EGCG is a complex molecule with flavanol as its core, accompanied by gallocatechol and gallate esters. gallate (6). EGCG has several health effects. Some of these effects include anti-inflammatory, anti-infective, antioxidant, anti collagenase, angiogenesis, and antifibrosis. This suggests that EGCG can be used for the treatment of dermal wounds by facilitating angiogenesis and reepithelialization (7).
Nutraceuticals-based therapeutic approach: recent advances to combat pathogenesis of Alzheimer’s disease
Published in Expert Review of Neurotherapeutics, 2021
Marjan Talebi, Eleni Kakouri, Mohsen Talebi, Petros A. Tarantilis, Tahereh Farkhondeh, Selen İlgün, Ali Mohammad Pourbagher-Shahri, Saeed Samarghandian
Flavonoids are secondary metabolites of plant origin, distributed mainly in fruits, leaves, and flowers of a plant. They are also found in vegetables and several beverages such as coffee and tea. They are classified into various groups according to the structural bonding of the B and C ring and the degree of hydroxylation and oxidation of the C-ring [96]. Concerning the IUPAC nomenclature, flavonoids can be categorized into three classifications: flavonoids or bioflavonoids, isoflavonoids (e.g. genistein), and neoflavonoids. Flavonoids could be additionally categorized into flavonols (e.g. rutin, quercetin), flavanones (e.g. hesperidin, naringenin), flavanols (e.g. epicatechin, gallocatechin), flavones (e.g. apigenin, luteolin), and anthocyanins (e.g. pelargonidin, malvidin) [97,98]. Flavonoids are consumed daily, and they are considered valuable molecules with multiple medicinal properties as they possess antioxidant, anti-inflammatory, and anti-cancer activity [85,99,100]. Additionally, in vitro and in vivo studies are pointed out their protective role against atherosclerosis, cardiovascular and neurodegenerative diseases including AD [101,102].
Low molecular mass natural and synthetic inhibitors of snake venom metalloproteinases
Published in Toxin Reviews, 2018
Lina María Preciado, Jaime Andrés Pereañez
Moreover, medicinal plant extracts are rich sources of natural inhibitors and have been shown to antagonize the activity of some venoms and metalloproteinases. As an example, isoquercitrin (Figure 1D), myricetin-3-O-glucoside (Figure 1E) and gallocatechin (Figure 1F), isolated from lyophilized aqueous extract of Schizolobium parahyba leaves, neutralized the biological and enzymatic activities of Bothrops venoms and the isolated metalloproteinase BjussuMP-I, from B. jararacussu venom. The flavonol glycoside isoquercitrin was able to inhibit hemorrhage induced by the venom, but did not show a high efficiency to inhibit fibrinogenolytic activity. On the contrary, myricetin-3-O-glucoside showed a potent inhibition of the fibrinogen proteolytic activity of B. alternatus venom but it did not inhibit hemorrhage, which may indicate a specific action against serine proteinase enzymes. On the other hand, gallocatechin was efficient in neutralizing the hemorrhagic and fibrinogenolytic activity induced by B. alternatus, B. jararacussu venom and BjussuMP-I metalloproteinase (Vale et al., 2011).