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Delivery of Herbal Cardiovascular Drugs in the Scenario of Nanotechnology: An Insight
Published in Mahfoozur Rahman, Sarwar Beg, Mazin A. Zamzami, Hani Choudhry, Aftab Ahmad, Khalid S. Alharbi, Biomarkers as Targeted Herbal Drug Discovery, 2022
Kumar Anand, Subhabrata Ray, Md. Adil Shaharyar, Mahfoozur Rahman, Rudranil Bhowmik, Sanmoy Karmakar, Monalisha Sen Gupta
Since ancient age, Green tea has been considered as healthy beverage and included in daily food list. According to East Asian medicine, Consumption of green tea has been suggested for headaches, body aches and pains, depression, digestion, and detoxification as well as an energizer. Generally, green tea is believed to prolong life (Cabrera, Artacho, and Gimenez, 2006). Epigallocatechin-3-gallate (EGCG) is the major component of green tea. EGCG of tea catechins is found to exert many cellular and molecular effects related to the health-promoting actions. In various research studies, it has been found that oral consumption of green tea may give protection against obesity-related disorders such as atherosclerosis, HTN, and diabetes. As a very important fact, it has been observed that only purified EGCG (50–100 mg/kg), and not any other green tea catechins, significantly reduced or prevented an increase in body weight (BW) in lean and obese Zucker rats (Kao et al., 2000). These above effects are appeared to be reversible and associated with a reduction in food intake.
Role of Plant-Based Bioflavonoids in Combating Tuberculosis
Published in Megh R. Goyal, Durgesh Nandini Chauhan, Assessment of Medicinal Plants for Human Health, 2020
Alka Pawar, Yatendra Kumar Satija
Epigallocatechin gallate is a phenolic antioxidant present in green and black tea. It is a chief form of catechin present in tea from Camellia sinensis. A content of 100–200 mg of EGCG may be present in a single cup of tea. It mainly acts as an antioxidant by inhibiting cellular oxidation and thereby prevents human cells from free radical damage. It has numerous health benefits, including antimicrobial activity against many bacteria and viruses. A decreased risk of TB disease is associated with high intake of tea.11 Although EGCG is the foremost biologically potent catechin in tea, yet its stability as well as bioavailability is limited.
Delivery Strategies and Formulation Approaches of Anticancer Nutraceuticals
Published in Sheeba Varghese Gupta, Yashwant V. Pathak, Advances in Nutraceutical Applications in Cancer, 2019
Epigallocatechin-3-gallate (EGCG) is a type of catechin found in green tea that exhibits a variety of activities such as anti-inflammatory, antidiabetes, antiobesity, and antitumor. The antitumor effects of EGCG including carcinogen activity, tumorigenesis, proliferation, and angiogenesis, and induced cell death were reviewed [57]. These effects are associated with the modulation of reactive oxygen species [ROS] production, which is mainly responsible for its anticancer effects despite its dual function of antioxidant and pro-oxidant potential. The EGCG-mediated inhibition of the nuclear factor (κB) signaling is also associated with the inhibition of migration, angiogenesis, and cell viability. Further, activation of mitogen-activated protein kinases activity upregulates the anticancer effect of EGCG on migration, invasion, and apoptosis. Additionally, EGCG causes the upregulation of apoptosis by inducing epigenetic modification through inhibition of DNA methyltransferase activity and regulation of acetylation on histone. Although EGCG promotes strong anticancer effects by multiple mechanisms, further studies are needed to define the use of EGCG in clinical treatment [58].
Enhanced therapeutic efficacy of doxorubicin against multidrug-resistant breast cancer with reduced cardiotoxicity
Published in Drug Delivery, 2023
Tianyu Zhang, Nuannuan Li, Ru Wang, Yiying Sun, Xiaoyan He, Xiaoyan Lu, Liuxiang Chu, Kaoxiang Sun
Epigallocatechin gallate (EGCG), a natural antioxidant component (Gan et al., 2018) which can be used as an antioxidant in various food additives, has also been used in the treatment of anti-tumor, cardiovascular diseases and other diseases (Wang et al., 2018). It can effectively remove oxygen free radicals in the body (Cheng et al., 2016). In addition to this, studies also show that EGCG can significantly inhibit the expression of P-gp (Satonaka et al., 2017). Therefore, the combination of DOX and EGCG can effectively prevent the cardiotoxicity of DOX and reverse the MDR in tumor cells. However, since EGCG is easily oxidized even under common physiological condition (Ziaunys & Smirnovas, 2022), it is critical to design a method that can not only protect the EGCG molecule from oxidation, but also effectively transport EGCG and DOX to the action site.
Attenuation of methotrexate induced hepatotoxicity by epigallocatechin 3-gallate
Published in Drug and Chemical Toxicology, 2023
Ayan Pradhan, Shilpa Sengupta, Ritika Sengupta, Mitali Chatterjee
Normal chow diet Nutri Lab Rodent was procured from Provimi Animal Nutrition India Pvt. Ltd. (Bangalore, India). All chemicals if not otherwise stated were obtained from Sigma-Aldrich (St. Louis, MO), except thiobarbituric acid (TBA, Spectrochem Pvt. Ltd., Mumbai, India, #Cat No. 012093), trichloroacetic acid (TCA, #Cat No. 204842), 5,5-dithio-bis 2-nitrobenzoic acid (DTNB, #Cat No. 012093, Sisco Research Laboratories, Mumbai, India), hydrogen peroxide (H2O2 30%, #Cat No. 204842, Merck India Limited, Mumbai, India), bovine serum albumin (BSA, HiMedia Laboratories Pvt. Ltd., Kolkata, India), aspartate aminotransferase (AST, #Cat No. OT-2009-03-001), alanine transaminase (ALT, #Cat No. LP-2009-05-001), alkaline phosphatase (ALP, #Cat No. LP-2009-03-001) assay kits (Accurex Biomedical Pvt. Ltd., Mumbai, India), lactate dehydrogenase (LDH, #Cat No. LDH1/1020/VER-03) assay kit (Coral Clinical Systems, Tulip Diagnostics (P) Ltd., Bambolim, India), Bio-Rad protein assay dye reagent (Bio-Rad Laboratories, Hercules, CA, #Cat No. 204842). Epigallocatechin gallate (C22H18O11, molecular weight 458.37, water solubility 40 g/l), a component of green tea was obtained commercially (PHR1333 Sigma-Aldrich, St. Louis, MO).
Integrative Management of Pancreatic Cancer (PDAC): Emerging Complementary Agents and Modalities
Published in Nutrition and Cancer, 2022
Mustafa B. A. Djamgoz, Valerie Jentzsch
Epigallocatechin gallate (EGCG) is abundant in teas, especially green tea, and fruits, especially berries (Table 1A). Epidemiological studies have shown beneficial effects of green tea on cancers of lung, breast, esophageal, stomach, liver and prostate (39, 40). As regards PDAC, however, such studies have given somewhat inconsistent results. Most meta-analyses concluded (i) that green tea consumption was not associated with PDAC risk and (ii) that high consumption was associated with slightly lower risk (41). This seemed more pronounced among Chinese populations (42, 43). Abe et al. recently evaluated the available epidemiological evidence for green tea consumption and showed that whilst PDAC risk was not affected, several other cancers were associated significantly with reduced risk (44). These included, importantly, liver cancer. Possible reasons for the discrepancy between the epidemiological data could include (i) the ranges of green tea consumption and (ii) compounding lifestyle factors especially smoking. Importantly, however, no adverse effect has been reported. Furthermore, green tea consumption could be beneficial indirectly by reducing the impact of diabetes, obesity and inflammation including pancreatitis (40, 45–47).