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Pulp Therapy for Primary Teeth
Published in M S Duggal, M E J Curzon, S A Fayle, K J Toumba, A J Robertson, Restorative Techniques in Paediatric Dentistry, 2021
M S Duggal, M E J Curzon, S A Fayle, K J Toumba, A J Robertson
Since the 1950s, much work has been done to evaluate the effect of formocresol on pulp tissue, including histological, biochemical and histochemi-cal enzymatic studies. Essentially, formocresol acts through the aldehyde group of formaldehyde, forming bonds with the side-groups of the amino acids of both the bacterial proteins and those of the remaining pulp tissue. It is therefore both a bactericidal and devitalizing agent. It kills off and converts bacteria and pulp tissue into inert
Clinical Progresses in Regenerative Dentistry and Dental Tissue Engineering
Published in Vincenzo Guarino, Marco Antonio Alvarez-Pérez, Current Advances in Oral and Craniofacial Tissue Engineering, 2020
Revascularization studies have established the following prerequisites: Revascularization occurs most predictably in teeth with open apices and necrotic pulp secondary to trauma.Apex is open more than 1 5 mmBacteria should be removed from the canal by any of the following methods: 3 mix—MP triple antibiotic paste consisting of ciprofloxacin, metronidazole and minocycline.Calcium hydroxide, formocresol.Effective control seal.Matrix into which new tissue can grow.Patient should beUse of anesthetic without a vasoconstrictor when trying to induce bleeding.No instrumentation of canalsSodium hypochlorite is used as an irrigant.Formation of blood clot probably serves as a protein scaffold permitting 3-dimensional in growth of tissue.
A randomized clinical trial of hyaluronic acid gel pulpotomy in primary molars with 1 year follow-up
Published in Acta Odontologica Scandinavica, 2022
Gökçe Çiçek Ildeş, Batın Ilgıt Sezgin, Alexandre Rezende Vieira, Ali Mentes
Pulpotomy is the most widely used endodontic treatment technique in primary dentition. Several agents, including calcium hydroxide (CH), formocresol (FC), ferric sulphate (FS), glutaraldehyde (GA), mineral trioxide aggregate (MTA), sodium hypochlorite (NaOCL), biodentine (BD), various lasers and electrosurgery have been used in primary molars [1,2]. FC has been used in paediatric dental clinics over 80 years for pulpotomy of primary teeth and established in trials as a ‘gold standard’ control [3]. FC was initially used in paediatric endodontics to mummify the remaining vital or necrotic pulpal tissue of primary teeth after the removal of the inflamed pulp chamber. FC is easy to use, cheap, has formaldehyde to exert bactericidal properties and reversibly inhibits enzymes in the inflammation, so it provides successful results [4]; however, its success is controversial for its safety concerns. Lewis [5] stated FC as problematic because of its toxicity, carcinogenicity, and genotoxicity. FS is a common haemostatic agent in dentistry. FS reacts with the pulp tissue upon its coverage and creates a shallow protective iron-protein layer complex. It reduces the risk of chronic inflammation and internal resorption but is not a regenerative material [6].
Efficacy of platelet concentrates in pulpotomy – a systematic review
Published in Platelets, 2018
Roshan Noor Mohamed, Sakeenabi Basha, Yousef Al-Thomali
Recent treatment approaches to pulpal infection or injury include the traditional root canal treatment with the use of improvised synthetic materials, which provide a better pulpal seal compared to CH or biological approach based on molecular and cellular basis for pulpal regeneration (2–5,9,11). Pulpotomy treatment for the primary or permanent teeth includes devitalization, preservation, or regeneration (5–8). Devitalization is done mainly in primary tooth by formocresol, electrosurgery, or by laser technique which destroys or mumifies the vital tissues (34–36). Preservation is done using zinc oxide eugenol, glutaraldehyde, or ferric sulfate pulpotomy, which maintains the maximum vital tissue with no induction of reparative dentin (34–37). Regeneration and formation of dentin bridge are done by CH (11), MTA (9,11), bone morphogenetic proteins, or growth factors (38). Platelet concentrates, an autologous derivative with a higher platelet concentration than baseline, is the material of choice for regeneration as it contains high growth factors and it forms fibrin matrix, which in turn holds growth factors in it. The present systematic review was conducted to analyze the efficacy of platelet concentrates in pulpotomy of primary or permanent teeth in humans. Four studies were included in the present review (26,27,30,31).
Which procedures and materials could be applied for full pulpotomy in permanent mature teeth? A systematic review
Published in Acta Odontologica Scandinavica, 2019
M. Zanini, M. Hennequin, PY. Cousson
The flow chart for study inclusion is presented in Figure 1. One single investigator (MZ) conducted the research on databases and for backward research. All three authors consensually agreed for abstracts to be excluded during the screening phase. During this screening phase, the criteria for exclusion were: not in English; in vitro studies; animal studies, reviews; comments; articles reporting pulpotomies on primary teeth, immature permanent teeth, or dens invaginatus; studies on vital direct pulp capping, partial excavation or partial pulpotomy; papers related to general issues in paediatric dentistry; studies related to the use of formocresol; articles retracted by the journal’s editor.