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Granulation of Plant Products and Nutraceuticals
Published in Dilip M. Parikh, Handbook of Pharmaceutical Granulation Technology, 2021
Ayurveda has recommended several drugs from indigenous plant sources for the treatment of asthma and allergic disorder, and has been successful in controlling these diseases as well. Some herbal drugs which are mainly used in the treatment of asthma are Albezzia Lebbeck, Euphorbia Hirta, Adhatoda Vasica, and Allium Capa. Madhavi lata (Hiptage benghalensis), native to India and the Philippines, is a vine-like plant that is often cultivated in the tropics for its attractive and fragrant flowers. It is used medicinally in India. Its bark, leaves, and flowers are aromatic, bitter, acrid, astringent, vulnerary, expectorant, cardiotonic, anti-inflammatory, and insecticidal.
Medicinal Plants in Natural Health Care as Phytopharmaceuticals
Published in Anil K. Sharma, Raj K. Keservani, Surya Prakash Gautam, Herbal Product Development, 2020
It is an erect annual or perrenial plant growing to 50 cm, with pointed oval leaves and clusters of small flowers. Pill-bearing spurges contain flavonoids, terpenoids, alkanes, phenolic acids, shikimic acid and choline. The latter two constituents may by partly responsible for the anti-spasmodic action of this plant. Euphorbia hirta is used to treat bronchial asthama; pill-bearing spurge relaxes the bronchial tubes and eases breathing. Mildly sedative and expectorant, it is also taken to treat intestinal amoebiasis (Sashini et al., 2018).
Ethnobotanical Survey for Managing Selected Non-Communicable Diseases
Published in Hafiz Ansar Rasul Suleria, Megh R. Goyal, Masood Sadiq Butt, Phytochemicals from Medicinal Plants, 2019
Godwin Ojochogu Adejo, Sunday Ene-Ojo Atawodi, Kingsley Okoyomoh
Euphorbia hirta extracts have been used in East and West Africa in treating asthma and respiratory tract inflammations. It is also used for the treatment of cough, chronic bronchitis, and other pulmonary disorders in Malagasy.151 The plant is also widely used in Angola against diarrhea and dysentery, especially amoebic dysentery.151 In Nigeria, extracts of the plant are used in the treatment of boils, sore, and also in promoting wound healing.151 The plant is used as a diuretic, an antidiarrheal, antispasmodic, and anti-inflammatory agent.151
Protective effect of Euphorbia thymifolia and Euphorbia hirta against carbon tetrachloride-induced hepatotoxicity in Wistar rats
Published in Drug Development and Industrial Pharmacy, 2022
Balamuralikrishnan Balasubramanian, Wen-Chao Liu, Vijaya Anand Arumugam, Durai Muthu Mani Gurupalraj, Manikandan Ramasamy, Shenbagam Madhavan, Shanmugam Velayuthaprabhu, Sungkwon Park
Phytochemicals are secondary metabolites of plants which possess antioxidant capacities and can reduce the liver disorders and prevalence of oxidative stress-related diseases in human [15,16]. Extracts of medicinal plants containing a high level of bioactive compounds are, there, often used for curing hepatic damage which can be caused by oxidative stress. Among these, Euphorbia thymifolia Linn. and Euphorbia hirta Linn. (Euphorbiaceae) are small branched-annual herb, commonly growing in India and tropical countries. Previous studies analyzed their nutritive values and reported that these plants, having antioxidant phytochemicals with anti-inflammatory effects, are hepatoprotective in the traditional medical system [17,18]. As synthetic drugs used in the treatment of liver damage show limitation and serious side effects, the hepatoprotective effects of E. thymifolia and E. hirta were evaluated in the current study. To this end, the study investigated the in vitro antioxidant capacities and the effects of ethanolic extracts of E. thymifolia and E. hirta on changes in body weight, hepatic marker, anti-oxidant enzyme activities, and liver histopathology in CCl4-induced hepatotoxic rats.
Therapeutic potentials of endophytes for healthcare sustainability
Published in Egyptian Journal of Basic and Applied Sciences, 2021
Ayodeji O. Falade, Kayode E. Adewole, Temitope C. Ekundayo
Of the 5 research items published on the hepatoprotective potentials of endophytes between 1990 and 2020, 3 (60%) were published between 2018 and 2020. Examples from these studies include ‘Ocimum sanctum Linn. endophytic fungal fraction’, which at 200 mg/kg p. o., significantly upturned the effects of carbon tetrachloride (CCl4)-induced hepatotoxicity, by normalization of serum aspartate transaminases (AST), alanine transaminases (ALT), alkaline phosphatase (ALP) and hepatic damage biomarkers relative to CCl4-treated group. Restoration of altered lipid peroxidation, glutathione (GSH) and CAT by the fungal extract suggest that the hepatoprotective effect is possibly via the antioxidant action of the extract [77]. The ethyl acetate extract of Achaetomium sp. hosted by Euphorbia hirta has been reported to protect against CCl4 induced toxicity in HepG2 cells as evidenced by 72.13% of cell viability at a concentration of 150 mg/mL compared to 93.26% cell viability reported for the standard, silymarin [78].
Ethnomedicinal plants used for treatment of snakebites in Tanzania – a systematic review
Published in Pharmaceutical Biology, 2022
Neema Gideon Mogha, Olivia John Kalokora, Halima Mvungi Amir, David Sylvester Kacholi
Moreover, the reported species in the present study have been reported elsewhere to have antivenin activities. For instance, the extract from combined roots, bark and leaves of Securidaca longipedunculata Fresen (Polygalaceae) (Sanusi et al. 2014), stem bark of Commiphora africana (A.Rich.) Engl. (Burseraceae) (Isa et al. 2015), folium extract of Dichrostachys cinerea (L.) Wight et Arn. (Fabaceae) (Agusi and Ogbunachi 2018), roots of Capparis tomentosa Lam. (Capparaceae) and Ziziphus mucronata Wild. (Rhamnaceae) (Molander et al. 2014), and those from the whole plant of Euphorbia hirta L. (Euphorbiaceae) inhibit venom activities of N. nigricollis. Also, extracts from leaves and roots of A. senegalensis inhibit venom activities of Echis ocellatus Stemmler (Viperidae), N. nigricollis and B. arietans (Molander et al. 2014), whereas extracts from aerial parts and roots of Cissampelos pareira L. var. orbiculata (DC.) Miq. (Menispermaceae) are reported to neutralize venom activity of Bothrops diporus Cope (Viperidae) (Verrastro et al. 2018). Leaves and roots extracts of Cassia occidentalis L. (Fabaceae) are reported to inhibit venom activities and accelerate wound healing caused by Bothrops moojeni Hoge (Viperidae) (Molander et al. 2014), while the roots and bark extract of Acalypha fruticosa Forssk. (Euphorbiaceae) (Molander et al. 2014), and Paullinia pinnata (Iful 2008; Sanusi et al. 2014) are reported to inhibit venom activities of Echis carinatus Schneider (Viperidae). Therefore, the present study highlights the wealthy knowledge locals in Tanzania possess in dealing with snakebites. It also suggests that further pharmacological scrutiny of the recorded medicinal plants is imperative in understanding bioactive compounds that can be used to prepare antivenin in modern science.