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Essential Oils: Clinical Perspectives And Uses
Published in Amit Baran Sharangi, K. V. Peter, Medicinal Plants, 2023
Jugreet Bibi Sharmeen, Mahomoodally Mohamad Fawzi
Furthermore, eucalyptus oil has been reported to be effective in the reduction of swelling, pain, and inflammation. For instance, Jun et al. (2013) investigated the effects of eucalyptus oil inhalation on pain and inflammatory responses after total knee replacement (TKR) surgery in a randomized clinical trial. Patients inhaled eucalyptus or almond oil (intervention and control group respectively) for 30 mins in continuous passive motion for 3 successive days. Pain measurement was derived from VAS, heart rate, BP, white blood cell (WBC) count and C-reactive protein (CRP) concentration recorded before and after inhalation. Remarkably, pain on VAS on all three days as well as systolic and diastolic BPs on the second day were significantly inferior in eucalyptus EO group compared to the group inhaling almond oil, although heart rate, CRP, and WBC did not change significantly in both groups. Hence, eucalyptus oil inhalation was found effective in reducing the patient’s pain and BP, suggesting that eucalyptus oil inhalation could be useful as a nursing intervention for pain relief following TKR surgery.
Eucalyptus spp. (Eucalypts) and Ficus religiosa (Sacred Fig)
Published in Azamal Husen, Herbs, Shrubs, and Trees of Potential Medicinal Benefits, 2022
Surendra Pratap Singh, Bhoomika Yadav, Kumar Anupam
Eucalyptus oil has many benefits, but eucalyptus also has some disadvantages. People who are allergic to eucalyptus oil should stop using it immediately. Excessive consumption of eucalyptus oil can be harmful to health. It contains toxic compounds (Dhakad et al., 2018).
Monographs of essential oils that have caused contact allergy / allergic contact dermatitis
Published in Anton C. de Groot, Monographs in Contact Allergy, 2021
There are two major eucalyptus oils: Eucalyptus globulus oil, obtained from Eucalyptus globulus Labill. and Eucalyptus citriodora oil. However, Eucalyptus citriodora oil is a misnomer (31). This oil is obtained from the citron-scent gum (lemon-scent gum) Corymbia citriodora (Hook) K.D. Hill & L.A.S. Johnson, which was formerly (and is still often today) incorrectly termed Eucalyptus citriodora Hook (31). This oil has a composition that is completely different (main components 69–84% citronellal and up to 12% neoisopulegol + isoisopulegol in the commercial chemotype oil) from that of oils obtained from Eucalyptus species (main component 62–89% 1,8-cineole [eucalyptol]) (31). Nevertheless, as both oils are termed ‘eucalyptus oil’, they are discussed here in this chapter ‘Eucalyptus oil’.
Design and development of essential oil based nanoemulsion for topical application of triclosan for effective skin antisepsis
Published in Pharmaceutical Development and Technology, 2022
Pratibha G. Kakadia, Barbara R. Conway
The EO-NEs showed two times higher drug permeation through the skin compared to the OO-NEs. This might be due to the formulations’ physicochemical properties, including higher solubility of TSN in EO, smaller droplet size, lower viscosity, and the permeation enhancing the effect of EO. Eucalyptus oil consists of 75% 1,8-cineole, a terpene that acts by creating liquid pools in the stratum corneum and disrupting the lipid structure of the stratum corneum, thereby increasing the permeation of drugs in the membrane (Shen et al. 2013; Herman and Andrzej 2015; Moghimipoura et al. 2018). A study by Williams and Barry (1989) reported the penetration enhancement activities of EO through excised human skin using 5-fluorouracil as a model drug. The in vitro permeation studies demonstrated that EO-6 (1.38 µg/cm2) provides greater drug permeation than EO-2 (1.13 µg/cm2), OO-2 (0.48 µg/cm2), and OO-6 (0.83 µg/cm2). The type and concentration of oil affected the flux (Jss) and permeability coefficient of the TSN (Table 5). The Jss values of the EO-6 formulation exhibited a 2-fold higher diffusion rate through skin compared to OO-NE formulations and 6-fold higher compared to control (p < 0.002).
Essential oils in niosomes for enhanced transdermal delivery of felodipine
Published in Pharmaceutical Development and Technology, 2019
Rania K. Eid, Ebtessam A. Essa, Gamal M. El Maghraby
With respect to the efficacy of the tested essential oils, clove oil and eucalyptus oil were of comparable efficiency with lemon oil being inferior when compared with respect to their potentiating effect on niosomal transdermal delivery of felodipine (Table 2). To explain the recorded synergistic effect for essential oils and niosomes in transdermal delivery of felodipine, the composition of each oil was considered. For clove oil, eugenol and its acetylated derivative are the main components in addition to small traces of other terpenes (Shen et al. 2007). These components are known to have skin penetration enhancing activity (Shen et al. 2007; Chen et al. 2015). The components of eucalyptus oil include 1,8-cineole, α-pinene, α-terpineol with small amounts of other terpenes (Song et al. 2009). Incorporation of eucalyptus oil resulted in increase in drug flux. This oil was shown to have skin penetration enhancing activity (Williams and Barry 1989). The work on this oil was even extended to develop eucalyptus oil microemulsion which was shown to enhance the transdermal delivery of hydrocortisone (El Maghraby 2008). In addition, cineole which is the major constituent of eucalyptus oil is known as an important chemical skin penetration enhancer with various authors reporting this function (Williams and Barry 1991; Yamane et al. 1995). For lemon oil, limonene, γ-terpinene and β-pinene are the main components (Gök et al. 2015). The neat oil was considered as skin penetration enhancer (Charoo et al. 2005). In addition to the neat oil, the principle component, limonene was examined as skin penetration enhancer with positive results being published (Williams and Barry, 1991; Diez et al. 1998).
Increases in NT-proBNP in the poisoned patient are probably multifactorial
Published in Clinical Toxicology, 2021
Matthew J. F. Bode, Kulanka H. Premachandra, Darren M. Roberts
Drs Lai, Graudins and Wong highlight the potential contribution of cardiorespiratory comorbidities on the raised NT-proBNP in a case of acute eucalyptus oil poisoning [1]. We similarly considered this, highlighting this and other biological factors that can increase NT-proBNP, including heart and kidney disease, and direct tissue injury [2].