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The Role of Plant-Based Natural Compounds in Inflammation
Published in Namrita Lall, Medicinal Plants for Cosmetics, Health and Diseases, 2022
Marcela Dvorakova, Premysl Landa, Lenka Langhansova
On the other hand, in study conducted by Hartung et al. (2019), resveratrol and its dimer, ε-viniferin, were both found to inhibit 5-LOX in cell-free assay with IC50 values of 7.3 µM and 0.8 µM, respectively, and in cell-based assay with IC50 values of 4.3 µM and 3.1 µM, respectively. In the context of other studies, the evaluated activity of resveratrol in the cell-free assay was surprising, while the IC50 value obtained in the cell-based assay was comparable with them (Boccellino et al., 2019; Werz, 2007).
Rhubarb
Published in Mahendra Rai, Shandesh Bhattarai, Chistiane M. Feitosa, Ethnopharmacology of Wild Plants, 2021
Gan B. Bajracharya, Richa K. Gupta
Stilbenes ε-viniferin (104) and ampelopsin B (105) showed a remarkable inhibitory effect on lipoxygenase and exhibited strong free radical scavenging activity against ABTS•+ radical cation (Ngoc et al. 2008).
Introduction
Published in Amritpal Singh Saroya, Reverse Pharmacology, 2018
As far as cosmetic application is concerned, cyclic nucleotide phosphodiesterase 4 (PDE4) was the most promising candidate. The others PDE1, 2, 3, 5 and 6 subtypes were not retained, which clearly indicates for a selectivity for PDE4. Investigatory tests with 6 subtypes of phosphodiesterase demonstrated a significant selectivity for phosphodiesterase 4 subtype. Evaluation of e-viniferin on the secretion of markers of inflammation confirmed the selectivity (Do et al. 2005).
Gastroprotective effect of leaf extract of two varieties grapevine (Vitis vinifera L.) native wild and cultivar grown in North of Tunisia against the oxidative stress induced by ethanol in rats
Published in Biomarkers, 2020
Nabil Saadaoui, Asma Weslati, Taha Barkaoui, Ikram Khemiri, Wafa Gadacha, Abdelaziz Souli, Moncef Mokni, Mounira Harbi, Mossadok Ben-Attia
The results of quantification of stilbenes by UPLC system were listed in Table 2. We obtained very different mean stilbene contents between the two genotypes (as well for the overall stilbenes content as well as for the different types of stilbenes detected). Six components were isolated from ‘Nefza-I’ spontaneous grapevine. cis-resveratrol was the major constituent of the extracts of wild grapevine leaves of ‘Nefza-I’ wild ecotype (88.82 ± 10.28 µg/g DM), followed by trans-piceid (64.86 ± 7.50 µg/g DM) and trans-resveratrol (56.65 ± 4.58 µg/g DM). Regarding, leaf extracts of cultivar variety ‘Marsaoui’ three compounds could not be quantified and the three others were detected but at levels that are significantly very lower in comparison with those of wild accession. The compounds established in descending order of concentration are as follow: trans-resveratrol (33.96 ± 2.36 µg/g DM), cis-piceid (25.66 ± 2.66 µg/g DM) and cis-ε-viniferin which was present at a very low level (2.29 ± 1.18 µg/g DM).
The anti-biofilm and anti-virulence activities of trans-resveratrol and oxyresveratrol against uropathogenic Escherichia coli
Published in Biofouling, 2019
Jin-Hyung Lee, Yong-Guy Kim, Chaitany Jayprakash Raorane, Shi Yong Ryu, Jae-Jin Shim, Jintae Lee
In a previous study, the anti-biofilm activities of resveratrol and its oligomers were investigated, and ε-viniferin and vitisin B were found to have greater activity than t-resveratrol in Pseudomonas aeruginosa (Lee et al. 2014). Interestingly, t-resveratrol and oxyresveratrol were found to be more effective at preventing biofilm formation by UPEC than the other five compounds (Figure 2B and C). While t-resveratrol and oxyresveratrol showed an inhibitory effect on biofilm formation, they could not disperse the established biofilms (Supplementary Figure S2).