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Platelet Disorders Douglas Triplett
Published in Genesio Murano, Rodger L. Bick, Basic Concepts of Hemostasis and Thrombosis, 2019
Thrombocythemia can also be seen in myelofibrosis, although the finding is rather variable. Bouroncle and Doan found the platelet count to be high in 23 of 97 patients.273 Although it is not unusual for a moderate to pronounced thrombocythemia to develop during the course of chronic myelogenous leukemia,274 recent work indicates that perhaps this syndrome should not be classified as a member of the myeloproliferative family.275
Chronic Back Pain
Published in Andrea Kohn Maikovich-Fong, Handbook of Psychosocial Interventions for Chronic Pain, 2019
Emily J. Ross, Jeffrey E. Cassisi, Kenneth R. Lofland
Particularly relevant to the chronic back pain population is the observation that depression and chronic pain frequently co-occur (Doan, Manders, & Wang, 2015). One recent study (Elfering, Käser, & Melloh, 2014), using cross-lagged analyses, found a bidirectional cycle between depression and pain levels such that depression ratings at intake predicted higher pain ratings at the next meeting; higher pain ratings at the next meeting in turn predicted higher depression levels at the next. As a result, the authors recommend that health practitioners screen for and treat depressive symptoms as early as possible in order to increase the chances of successful intervention.
Toys are so analogue
Published in David Cohen, How the child's mind develops, 2017
In the light of this, Cris Rowan, the author of Virtual Child (2010), Dr Andrew Doan, the author of Hooked on Games (2012), and Dr Hilarie Cash, Director of the reSTART Internet Addiction Recovery Program and author of Video Games & Your Kids (Cash and McDaniel 2008), have developed some guidelines with the American Academy of Pediatrics and the Canadian Pediatric Society.
Low toxicity in hematological and biomedical parameters caused by bupernorphine in lactating female rats and their newborns
Published in Toxin Reviews, 2021
Tahereh Farkhondeh, Milad Ashrafizadeh, Omid Mehrpour, Babak Roshanravan, Saeed Samarghandian
Data regarding the transfer of BUP to newborns via breast milk are not sufficient (Tsai and Doan 2016). To our knowledge, BUP is distributed into the breast milk 2 h after its administration, and more BUP is observed in breast milk than in maternal plasma over 24 h (Lindemalm et al. 2009). BUP’s transfer to the newborn’s blood circulation and tissues may be related to the pH in the stomach, intestinal absorption, and metabolism in the liver, as well as protein binding, lipid solubility, and molecular weight (Mittal 2014). It was indicated that urine levels of BUP and nor-buprenorphine (nBUP) in breastfed babies exposed to BUP were less than 1% (very low) (Brown et al. 2011). It is suggested that the bioavailability of BUP is very low and it cannot cause clinical side effects in infants (Ilett et al.2012). It was suggested that higher doses of BUP might cause complex effects on various tissues in neonates (Wiles et al. 2014). Recent studies have suggested that opioids can affect hematopoiesis, blood cell biology, and hematological properties (Haghpanah et al. 2010). The effect of opioids on hematological parameters, glucose, lipid profile, and also liver and kidney function is controversial in abusers (Orum et al. 2018). Some studies confirmed the toxic effects of opioids on some hematological parameters (Asadikaram et al. 2013, Kaur et al. 2016). However, another study indicated no change in the above-mentioned parameters in opioids users (Soykut et al. 2013).
Integrating reproductive health care into substance use disorder services
Published in International Review of Psychiatry, 2021
Miriam McQuade, Neha Reddy, Kyle Barbour, Lauren Owens
In terms of postpartum concerns, neonatal abstinence syndrome (NAS) is often of concern for pregnant people who use opioids. One of the best ways to minimize the risks of NAS to the infant is through breastfeeding and many professional organizations recommend it as a nonpharmaceutical treatment of NAS (Cook & Larson, 2019; Tsai & Doan, 2016; Welle-Strand et al., 2013). Even still, the rates of breastfeeding for postpartum people using opioids remain low (Tsai & Doan, 2016). Often a diagnosis of NAS initiates the separation of the parent and child which, in association with irritability, lack of suck-swallow coordination and vomiting can make breastfeeding continuation more difficult (McQueen et al., 2011). Additionally, healthcare workers’ lack of knowledge about the benefits of breastfeeding for the reduction of NAS symptoms can discourage postpartum patients from breastfeeding and can spread misinformation (Balain & Johnson, 2014). Utilizing a checklist for best practices for pregnancy care for people with OUD can improve rates of counselling about the benefits of breastfeeding(Goodman et al., 2019).
Association between antibiotics and gut microbiome dysbiosis in children: systematic review and meta-analysis
Published in Gut Microbes, 2021
Lucy McDonnell, Alexander Gilkes, Mark Ashworth, Victoria Rowland, Timothy Hugh Harries, David Armstrong, Patrick White
Beta-diversity was reported in 3 studies and significantly reduced in 2 of those.29,33,35 Bokulich examined the impact of exposure to several different classes of antibiotics: cephalosporins, beta-lactams, macrolides, quinolones, and nitrofurantoin.33 They found that although microbiome alpha-diversity was unchanged following antibiotic exposure, beta-diversity differed significantly between children exposed to antibiotics and those unexposed (UniFrac distance, permutational MANOVA, R2 < 0.01 p < .001).33 This means that although the individual diversity index did not change (i.e. wide species variety and abundance) there was a significant change in the types of species found. With regards to azithromycin exposure alone, Wei reported associations with reduced alpha and beta diversity.29 Doan however found that beta diversity was unaffected (i.e., similar types of species in the two groups) following azithromycin exposure. But there was a 43% decrease in Simpson’s community-level gamma diversity (p < .001) which reflected the overall reduction in bacterial diversity of the treatment group compared to the placebo group.35 Six of eight studies reporting on species diversity found a significant association between antibiotic use and a reduction in species diversity.