China
Africa
Explore chapters and articles related to this topic
Monographs of fragrance chemicals and extracts that have caused contact allergy / allergic contact dermatitis
Published in Anton C. de Groot, Monographs in Contact Allergy, 2021
2,4,6-Trimethyl-4-phenyl-1,3-dioxane is a colorless to pale yellow clear liquid; its odor type is floral and its odor at 100% is described as ‘fresh citrus gardenia green natural’ (www.thegoodscentscompany.com). 2,4,6-Trimethyl-4-phenyl-1,3-dioxane is a synthetic chemical, not found in nature (and consequently not in essential oils (3)).
The Liquid Scintillation Counting Process. The Gamma Counting Process
Published in Howard J. Glenn, Lelio G. Colombetti, Biologic Applications of Radiotracers, 2019
One of the problems associated with the use of aromatic solvents is the small amount of water they are capable of holding. Most samples of interest to pharmacologists contain varying amounts of water, p-Dioxane is a water-miscible organic substance also capable of dissolving various organic solutes and will, therefore, hold much larger quantities of water in homogeneous solution for liquid scintillation counting. Care must be taken to use peroxide-free dioxane because of the great quenching characteristics of peroxides. Table 2 lists the composition of some common liquid scintillation formulations using dioxane.
Tissue Preparation for Liquid Scintillation and Gamma Counting — the Counting Processes
Published in Lelio G. Colombetti, Principles of Radiopharmacology, 2019
Howard J. Glenn, Lelio G. Colombetti
One of the problems associated with the use of aromatic solvents is the small amount of water they are capable of holding. Most samples of interest to pharmacologists contain varying amounts of water, p-Dioxane is a water-miscible organic substance capable also of dissolving various organic solutes and will, therefore, hold much larger quantities of water in homogeneous solution for liquid scintillation counting. Care must be taken to use peroxide-free dioxane because of the great quenching characteristics of peroxides. Table 4 lists the composition of common liquid scintillation solutions using dioxane.
Supramolecular self-assembly of a hybrid ‘hyalurosome’ for targeted photothermal therapy in non-small cell lung cancer
Published in Drug Delivery, 2020
Haipeng Xu, Lin Dong, Zhang Bin, Huo Yansong, Lin Shaofeng, Liu Chang, Chen Chen, Wang Changli
Oleic acid (10 mmol) was dissolved in 20 mL of dichloromethane, then N-boc-3-amino-glycerin (3.3 mmol), EDC (3 mmol), and DMAP (3 mmol) were added, and the mixture was stirred for 24 h at room temperature under nitrogen. The obtained Boc-protected DOAP was isolated and purified by silica column chromatography (petroleum ether/ethyl acetate ¼ 20:1). Subsequent deprotection was performed using a hydrochloride acid solution in 1,4-dioxane, which yielded 82% DOAP. For synthesis of the DO-g-HA, hyaluronic acid (HA, 5 μmol) was dissolved in formamide, and equal amounts (1.5 equivalent of HA) of EDC and NHS were added to activate the carboxyl group. Then, at various molar ratios, DOAP was introduced to HA, and the reaction mixture was agitated at room temperature in the dark. The product was dialyzed against distilled water (MWCO: 15 kDa, Viskase Companies Inc., Lombard, IL) successively to remove the reactant remnant after an additional 24-h incubation. The desired compound was obtained as a solid after lyophilization. The final products were generally obtained at a 70% yield. The 1H NMR spectra were recorded on a 300 MHz spectrometer at ambient temperature with CDCl3 as the solvent (Bruker AVACEAV-500, Fällanden, Switzerland).
Novel phthalimide based analogues: design, synthesis, biological evaluation, and molecular docking studies
Published in Journal of Enzyme Inhibition and Medicinal Chemistry, 2019
Ismail M. M. Othman, Mohamed A. M. Gad-Elkareem, Mohamed El-Naggar, Eman S. Nossier, Abd El-Galil E. Amr
A solution of 4 (2.7 mg, 10 mmol) in dry dioxane (30 ml) and DMF–DMA (12 mmol) was refluxed for 3 h. After cooling, the solid produced was get by filtration and crystallized from toluene to yield compound 10 as yellow crystals (62%), m.p 136–138 °C; IR (KBr): υ cm−1 3407, 3352 (2NH), 3048 (CH-arom.), 2939 (CH-aliph.), 1733, 1681, 1662 (3 C=O), 1620 (C=N); 1H NMR (DMSO-d6) δ = 2.75 (s, 6H, N(CH3)2), 7.44–7.82 (m, 5H, Ar-H + NH), 8.01 (s, 1H, N=CH). 12.46 (s, 1H, NH); 13C NMR (DMSO-d6): 35.8, 123.2, 132.1, 133.7, 136.5, 150.9, 154.4, 164.6, 167.0. Analysis for C14H13N7O3 (327.30): Calculated: C, 51.38; H, 4.00; N, 29.96%. Found: C, 51.60; H, 4.20; N, 29.74%.
Synthesis, characterization, antimicrobial and antimetastatic activity of silver nanoparticles synthesized from Ficus ingens leaf
Published in Artificial Cells, Nanomedicine, and Biotechnology, 2018
Doga Kavaz, Huzaifa Umar, Shafiu Shehu
The major compounds present are ethanol, 1-(2-butoxyethoxy) (16.9%), cyclohexane propanol (11.6%), 2-methoxy-6-methyl pyrazine (13.8%), 11,3-dioxane (CAS) (6.8%), 2-propenoic acid octyl ester (6.31%), dihydro methyl jasmonate (7.62), 1,2-benzene dicarboxylic acid (7.31%) and 4-(bromomethyl) cyclohexane-1-ol (2.11%). Other compounds that are present in the plant extract are 2-methoxy-6-methyl pyrazine diethyl ester, cyclohexane, stearic acid, 3-oxy-4-octene, neophytadiene, pyrrolidine, 1-(1-pentenyl)-(CAS) 1-(1-pyrrolidinyl)-1-n-pentene, pentanoic acid, pentyl ester (CAS) amyl valerate, pyrrolidine, 1-(1-pentenyl)-(CAS) 1-(1-pyrrolidinyl)-1-n-pentene. Ability of plant to combat diseases or its medicinal properties has to do with the bioactive compounds present in the plants. Some of this compounds have medicinal properties and can cure many diseases including cancer. Kucuk et al. reported that 1,3-dioxane has strong ability to combat cancer and fungal related infection [23]. Also, many compounds that have carboxylic functional group that are present in the extract have reported to have antibacterial and anticancer activity [24].