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Nail Product Rheology
Published in Laba Dennis, Rheological Proper ties of Cosmetics and Toiletries, 2017
Ikeda et al. (28) determined through x-ray diffraction that the interlaminar distance of Bentone 27 powder is 9.4 A. They further determined that chipping is an effective way to obtain dispersion, but that dibutyl phthalate did not expand the interlaminar distance. They claim that polyethylene glycols, polypropylene glycols, their esters (e.g., polyoxyethylene lauryl ethers), and esters of dicarboxylic acids (C4 through CIO) (e.g., dibutyl sebacate) expand the interlaminar distance considerably. Furthermore, they claim that aromatic hydrocarbons such as toluene and xylene, which are important in conventional systems, may be deleted from the nail polish composition of their invention and replaced by ingredients such as isoparaffins or hexane.
Topical Formulations for Onychomycosis: A Review
Published in Andreia Ascenso, Sandra Simões, Helena Ribeiro, Carrier-Mediated Dermal Delivery, 2017
Barbara S. Gregorí Valdes, Carolina de Carvalho Moore Vilela, Andreia Ascenso, Joao Moura Bordado, Helena Ribeiro
The same author performed another study [78] and reported the nail penetration of tavaborole (AN2690) from different vehicles and compared with ciclopirox. Four formulations, all containing 10% (w/w) AN2690 were compared for their ability to deliver AN2690 to the deep layers of the nail plate and into the nail bed. The composition (w/w) of these different vehicles was: formulation A: 70% ethanol and 20% poly (vinyl methyl ether alt maleic acid monobutylester), a polymer that forms a water-insoluble film, very durable and resistant to damage; formulation B: 56% ethanol, 14% water, 15% poly (2-hydroxyethyl methacrylate) and 5% dibutyl sebacate, forming a water soluble film; formulation C: 55% ethanol, 15% ethyl acetate, 15% poly (vinylacetate) and 5% dibutyl sebacate, forming a water- insoluble film that can be removed by peeling or scratching the surface; formulation D: 20% propylene glycol and 70% ethanol (only solvents). Aliquots of those formulations were applied on human nail plates once daily for 14 days. The ventral/ intermediate nail samples were collected at the end of the 14th day dose period, stored at 4°C and analyzed for drug by LC/MS/MS. Considering that any formulation showed a clear advantage over the others, the simplest formulation (D) was chosen for further development [78].
Effect of substitution of plasticizer dibutyl phthalate with dibutyl sebacate on Eudragit® RS30D drug release rate control
Published in Pharmaceutical Development and Technology, 2019
Rakesh Singh Chaudhary, Tejas Patel, Job Richard Kumar, Mohamed Chan
The study conducted to substitute plasticizer dibutyl sebacate is evaluated which is recommended plasticizer for the Eudragit® RS 30D and provides similar plasticization as dibutyl phthalate on the glass transition temperature and minimum film forming temperature. The dibutyl sebacate has a solubility in water around 40 mg/L at 20 °C, and it is odorless and colorless. It exhibits characteristic thermal behavior above −10 °C as it remains as a liquid with a boiling point of 344 °C. The toxicological data available classify it as non-toxic after oral administration and also considered non-irritating on dermal contact (Snejdrova and Dittrich 2012).