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Plant-Based Essential Oils in The Treatment of Microbial Infections
Published in Mahendra Rai, Chistiane M. Feitosa, Eco-Friendly Biobased Products Used in Microbial Diseases, 2022
Hercília Maria Lins Rolim, Alessandra Braga Ribeiro, Monalisa de Alencar Lucena, Andressa Barros Ibiapina, Thais Cruz Ramalho
Considered one of the main genus of the Euphorbiaceae family, the genus Croton is widely distributed in the Northeast region of Brazil. Many species of this genus have tremendous economic importance due to the great natural compounds diversity, with several pharmacological properties, emphasizing on anti-inflammatory, gastroportiva, antiulcerogenic, antioxidant and antimicrobial activities, which justifies the wide use in traditional medicine by the local population. Most species of this genus, such as Croton cajucara, Croton campestris and Croton heliotropiifolius, are rich in essential oils with complex chemical composition formed by monoterpenes, sesquiterpenes and phenylpropanoids (Da Costa et al. 2013; Martins et al. 2017).
Exploring Important Herbs, Shrubs, and Trees for Their Traditional Knowledge, Chemical Derivatives, and Potential Benefits
Published in Azamal Husen, Herbs, Shrubs, and Trees of Potential Medicinal Benefits, 2022
Tilahun Belayneh Asfaw, Tarekegn Berhanu Esho, Archana Bachheti, Rakesh Kumar Bachheti, D.P. Pandey, Azamal Husen
Croton macrostachyus Del. (Family: Euphorbiaceae) (Figure 1.9) is a common evergreen shrub or tree growing in forests and along rivers or lakes. The plant's common names are “spurge” family, woodland, “forest fever tree”, or “broad-leaved Croton”. This plant is a deciduous tree that grows to 6–12 m high and is usually propagated by cuttings and seedlings. The plant is a leafy shrub growing up to 4 m, the stem is brittle and breaks easily. The leaves of this shrub are large and green, turning to orange before falling, ovate, base subcordate or rounded, apex acuminate, margin crenulated serrulate or sub-entire; with the leaves are 5–19 cm wide and 3.5–15 cm long. The flowers are a creamy yellow–white color, sweetly scented, and up to 3 mm long and these have at least one separate shoot tip. An ethnobotanical study of the fruits showed that the plant has medicinal value in the treatment of malaria, diarrhea, rabies, toothache, cancer, abdominal pain, pneumonia, gastrointestinal disorder, etc. (Abdisa, 2019). Experimental studies indicated that the plant has different medicinal values against foodborne diseases, drug-resistant infectious agents, and abortifacient and uterotonic to expel retained placenta (Abdisa, 2019).
Croton zehntneri: Essential Oils and Inclusion Complex
Published in Mahendra Rai, Shandesh Bhattarai, Chistiane M. Feitosa, Ethnopharmacology of Wild Plants, 2021
Lorenna Fonseca, Mahendra Rai, Sidney Gonçalo de Lima
Croton L. is the second largest genus of the Euphorbiaceae family and the most studied in Brazil and abroad, with about 1200 species, and has a pantropical distribution, with approximately 712 species on the American continent, and in Brazil, 350 are species widely distributed in the more diverse environments, with emphasis on the Cerrado, Caatinga and Campos Rupestres (Craveiro et al. 1978, Sodré and da Silva 2015, Alves et al. 2019). In the Northeast region of Brazil, Croton species are popularly known as canopies or quince trees. They are characterized by the presence of latex in their stems, produce essential oils with pleasant odors and are used for the most diverse purposes, including for medicinal use (Craveiro et al. 1978, Oliveira-Tintino et al. 2018).
Development of a nanotechnological hydrogel containing desonide nanocapsules in association with acai oil: design and in vivo evaluation
Published in Pharmaceutical Development and Technology, 2022
Priscila Rosa, Mariane Lago Friedrich, Juliana dos Santos, Natháli Schopf Pegoraro, Camila Camponogara, Sara Marchesan Oliveira, Cristiane de Bona da Silva, Andréa Inês Horn Adams
The antiedematogenic activity of the nanostructured hydrogels in an acute contact dermatitis model induced by croton oil was assessed. Croton oil contains 12-O-tetradecanoylphorbol-13-acetate (TPA) and other phorbol esters as main irritant agents (Saraiva et al. 2011). Its application triggers an inflammatory response characterized by edema, leading to increased vascular permeability, cell infiltration and proliferation, production of arachidonic acid metabolites, cytokines and other proinflammatory mediators (Patrick et al. 1987; Rao et al. 1993). A recognized immediate effect of TG includes vasoconstriction, which decreases the tissue edema, erythema and heat (Beltrani et al. 2005). Thus, our aim was to assess the antiedematogenic effect of the nanostructured hydrogels in a model of croton oil-induced skin inflammation, since it mimics several human skin diseases, such as psoriasis and atopic dermatitis (Sato et al. 2004; Pietrovski et al. 2011).
Meta-inhibition of ocular and gastrointestinal dysfunctions by phenolic-rich fraction of Croton zambsicus leaves in a rat model exposed to chronic mixed metals
Published in Cutaneous and Ocular Toxicology, 2021
J. K. Akintunde, O. R. Omoniyi, O. E. Folorunsho, C. A. Moses
Croton zambsicus belongs to the family Euphorbiaceace22. It is a decorative plant grown in West Africa particularly in most part of tropical Africa22. Stem bark and seed aqueous extract of Croton zambsicus has shown antimalarial activity23. The leaves were discovered as an anti-hypertensive, anti-microbial, anti-diabetic24. and anti-cancer18 agents. Phenolic compounds are natural free radical scavengers, peroxide decomposers25,26 and lipid oxidation inhibitors27. Pharmacologically, no strong experimental study had been reported on novel indicators of oculopathy and gastrointestinal dysfunction in a rat model especially when exposed to chronic mixture of environmental metals. For this purpose, we tested if phenolic components from Croton zambiscus leaves could serve as phyto-therapeutic agent against exposure to chronic mixed-metals that contribute to ocular and colon toxicity in a rat model.
Pharmacokinetics and tissue distribution of crotonoside
Published in Xenobiotica, 2018
Peiao Yan, Lan Zhang, Cheng Peng, Ruoqi Zhang
Croton Herba is the dried fruit of Croton tiglium L., which is a species of plant from the genus Croton of the family Euphorbiaceae. Croton Herba, which is widely used in Traditional Chinese Medicine, has been shown to possess a variety of pharmacological activities (National Pharmacopoeia Committee, 2015) and shows different therapeutic effects in the clinic, according to the different routes of administration. Croton Herba is orally administered to treat constipation, acute throat trouble, dyspepsia and externally administered to treat skin diseases (National Pharmacopoeia Committee, 2015).