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Fungi and Water
Published in Chuong Pham-Huy, Bruno Pham Huy, Food and Lifestyle in Health and Disease, 2022
Chuong Pham-Huy, Bruno Pham Huy
Recently, many bioactive constituents of C. sinensis have been reported, such as polysaccharides, cordycepin, cordycepic acid, guanosine (a nucleotide), mannitol, aminophenol, unsaturated fatty acids, metals, and ergosterol (88–91). Recent studies have demonstrated that the chemical constituents extracted from Cordyceps have various pharmacological actions, such as immunomodulating, nephroprotective, hepatoprotective, inflammatory effects, antioxidant, anti-aging, and antiapoptotic properties (88–92). However, safety concerns associated with the daily consumption of Cordyceps fungi or related products are still being debated (92). On the one hand, the known compounds from these fungi such as adenosine analogs cordycepin and pentostatin have demonstrated different beneficial and pharmaceutical activities, but on the other hand, dose-dependent cytotoxicities, neurological toxicities, and/or toxicological effects have also occurred in humans and animals (92). The possibility of mycotoxin production by Cordyceps fungi has not been completely ruled out (92). Based on the known compounds and putative mycotoxins that might be produced by Cordyceps fungi, safety assessments and more research are still required to alleviate concerns when consuming these costly fungi as dietary supplements (92).
Medicinal Plants of China Focusing on Tibet and Surrounding Regions
Published in Raymond Cooper, Jeffrey John Deakin, Natural Products of Silk Road Plants, 2020
Jiangqun Jin, Chunlin Long, Edward J. Kennelly
Chemical constituents: Polysaccharides, mannitol, cordycepin (Figure 2.13), aminophenol ergosterol (Yue et al., 2013), adenosine, sterols, peptides (cordymin and myriocin), melanin, lovastatin, γ-aminobutyric acid, and cordysinins (Lo et al., 2013).
Current Concepts of Implantation and Decidualization
Published in Gabor Huszar, The Physiology and Biochemistry of the Uterus in Pregnancy and Labor, 2020
Drugs and inhibitors have been used to examine the influence of DNA, RNA and protein synthesis on trophoblast differentiation. A clear pattern cannot be drawn, as yet, because of the lack of rigorous controls for drug toxicity and other side effects. Inhibition of DNA synthesis (cytosine arabinoside) affected ICM more than tro-phectoderm. Lower DNA content did not appear to interfere with trophoblast differentiation.73 The blastocyst was extremely sensitive to actinomycin-D and cordycepin.74 As little as 0.001 jig/mi of antinomycin-D caused blastocyst destruction. The secondary and side effects produced by actinomycin-D can be partially circumvented by the use of α-amanatin.75 Cell-specific but not stage-specific proteins are suppressed by α-amanitin.76 The results of these experiments reinforce the view that relatively stable RNA populations support initial stages of development.75,77 New species of mRNA are required from the morula on.
Nanoencapsulated cordyceps extract enhances collagen synthesis and skin cell regeneration through antioxidation and autophagy
Published in Journal of Microencapsulation, 2023
Nawapol Upatcha, Palakorn Kaokaen, Natchadaporn Sorraksa, Ruchee Phonchai, Phongsakorn Kunhorm, Nipha Chaicharoenaudomrung, Parinya Noisa
To determine the effect of the absorption level, secretory protein level, and wound healing on HDF cells. The cordycepin absorption level in the suspension medium was evaluated by HPLC as shown in Table 3. The normal condition results showed, the concentration of cordycepin at incubation times (0, 15, 30, 60, 120, 240, and 480 min.) of C was 5.52, 5.35, 5.13, 4.29, 3.79, 2.98, and 2.64 µM, respectively. The CM was 5.50, 4.29, 3.44, 1.34, 0.82, 0.35, and 0.24 µM, respectively. The CMP was 5.47, 4.11, 2.29, 1.17, 0.81, 0.29, and 0.19 µM, respectively. The cordycepin release profiles after treatment and the supernatant of treated cells was evaluated by HPLC and calculated compared with the initial concentration as the percentage of cordycepin release as shown in Table 3. The results showed, the percentage of cordycepin release profiles at incubation times (0, 15, 30, 60, 120, 240, and 480 min.) of CMP was 0%, 24.8%, 58%, 78.5%, 85.1%, 94.7%, and 96.4%, respectively.
Cordycepin mitigates spermatogenic and redox related expression in H2O2-exposed Leydig cells and regulates testicular oxidative apoptotic signalling in aged rats
Published in Pharmaceutical Biology, 2022
Spandana Rajendra Kopalli, Kyu-Min Cha, Jae Youl Cho, Si-Kwan Kim, Sushruta Koppula
Cordyceps (Cordycipitaceae) is a well-known traditional medicinal mushroom with immense biological activities including immunomodulatory, anticancer, antioxidant, anti-inflammatory and antimicrobial activities (Tuli et al. 2014; Olatunji et al. 2018). Out of various species, Cordyceps militaris Linn., is widely used in Asian countries, including China and Korea, to maintain health and boost immunity (Tuli et al. 2014). One of the active constituents of C. militaris, cordycepin (3′-deoxyadenosine), a purine nucleoside derivative is a valuable medicament and nutrient with immense health benefits (Tuli et al. 2014; Olatunji et al. 2018; Radhi et al. 2021). Recent reports indicated that cordycepin possessed anti-inflammatory, antitumor, neuroprotective and immunomodulatory effects (Nallathamby et al. 2015; Olatunji et al. 2016; Wang et al. 2019; Xu et al. 2019; Lee et al. 2020; Jin et al. 2021). In relation to reproductive health benefits, cordycepin has been proved to enhance sexual function, treat erectile dysfunction, and acts as a sexual agonist in male reproductive problems (Chen et al. 2017). Previous studies from our laboratory also showed that cordycepin attenuated age-related oxidative stress and sexual dysfunction by improving the sperm kinematics, altering the antioxidative enzyme status, and reproductive hormones in experimental aged rats (Ramesh et al. 2012; Kopalli et al. 2019). However, the beneficial effects of cordycepin related to oxidative stress-induced changes in Leydig cells and the spermatogenic molecular aspects involved have not been reported.
Cordycepin-loaded Nanoparticles from Cassava Starch Promote the Proliferation of Submandibular Gland Cells and Inhibit the Growth of Oral Squamous Carcinoma Cells
Published in Nutrition and Cancer, 2021
Palakorn Kaokaen, Atchara Jaiboonma, Nipha Chaicharoenaudomrung, Phongsakorn Kunhorm, Kajohnkiart Janebodin, Parinya Noisa, Paiboon Jitprasertwong
Medicinal herbs have been widely used throughout the history as components of food, tonics, and decoctions for the treatment of various diseases. Currently, there is much interest in the evaluation of herb-based substances with potential medicinal usefulness. Cordyceps militaris is a type of Chinese herb that been extensively researched. The herb can be consumed for nourishment or to treat ailments, in addition to having anticancer properties. Cordycepin (CS) (3′-deoxyadenosine) is recognized as the active component of Cordyceps spp. (1). Previous studies have shown that CS has anti-oxidant properties capable of inhibiting the growth and promoting the death of cancer cells (2,3). It also has anti-inflammatory, antibacterial, and antifungal properties and has been shown to enhance the development of immune cells (1,4–6).