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An Introduction to the Ethnopharmacology of Wild Plants
Published in Mahendra Rai, Shandesh Bhattarai, Chistiane M. Feitosa, Ethnopharmacology of Wild Plants, 2021
Shandesh Bhattarai, Christiane Mendes Feitosa, Mahendra Rai
Similarly, some other approved drugs are Aloe for treatment of burns and wounds isolated from [Aloe species] (Marinelli 2005), followed by Black cohoshv for the treatment of hormonal disorders, rheumatism, from Black cohosh [Cimicifuga racemosa] (Marinelli 2005), Bloodroot for the treatment of skin disorders and cancer from Bloodroot [Sanguinaria canadensis] (Robbins 1999). Likewise, Camphor for rheumatic pain relief from the wood of Camphor tree [Cinnamomum camphore] (Tuxhill 1999). Colchicine is used for cancer and gout treatment from Autumn crocus [Colchicum autumnale] (Tuxhill 1999), and Devil’s club for infection cure, diabetes, and tuberculosis from Oplopanax species (Marinelli 2005, MPWG 2007). Species of the genus Tabebuia have a history of use in the treatment of several diseases including syphilis, fevers, malaria, cutaneous infections, and stomach disorders (Cragg et al. 2002).
Evaluation of Anti-ulcer Potential of Sphenodesme involucrata var. paniculata (C.B. Clarke) Munir Leaves on Various Gastric Aggressive Factors
Published in Parimelazhagan Thangaraj, Phytomedicine, 2020
P. S. Sreeja, K. Arunachalam, Parimelazhagan Thangaraj
Even though there are hundreds of compounds isolated from plants with medicinal properties, some compounds, like taspine, isolated from Croton lechleri, has both anti-inflammatory property by reducing the inflammatory process, as well as gastroprotection property by reducing the H. pylori bacteria content in the stomach. Thus Taspine demonstrates that it has multitargets of the therapeutic property for curing diseases and, hence, it is able to be used for more than one illness, both anti-inflammatory, as well as gastroprotection. In same way, the compound colchicine derived from Colchicum luteum possesses anti-inflammatory activity, pain relieving effects on joints and relief from bronchial diseases; salicin from the plant Salix alba proves to have analgesic and anti-rheumatic properties, and is also a proven febrifuge; marrubiin obtained from the plant Marrubium vulgare demonstrated anti-nociceptive and vasorelaxant activity; and glycirrhizin derived from the plant Glycyrrhiza glabra can be used as an expectorant and also for duodenal ulcer and inflammation treatment (Sultan et al. 2013; Jain 2016; Uritu et al. 2018).
Catalog of Herbs
Published in James A. Duke, Handbook of Medicinal Herbs, 2018
Colchicum has long been used medicinally for its cathartic and emetic properties as well as a remedy for gout, but not for arthritis. Colchicine is one of several compounds said to both cause and “cure” experimental cancers. 3-Desmethylcolchicine (isolated from Colchicum speciosum) has certain advantages over other antitumor colchicine derivatives, one of which (demecolcine or/V-deacetyl-/V-methylcolchicine) has been recognized, temporarily at least, as a clinically active antitumor agent.10 In bioassay, 3-desmethylcolchicine, has shown significant activity against the L-1210 lymphoid leukemia in mice and cytotoxicity against cells derived from human carcinoma of the nasopharynx.10 Powdered seed have been introduced into alcoholic beverages for homicidal purposes. It has also been used for rheumatism, and as an alterative, cathartic, diuretic, emetic, and sedative.32 Corms are usually sold in transverse slices, notched on one side and sometimes reniform in outline, white, and starchy internally. Widely grown as an ornamental. The poisonous alkaloid, colchicine, is used in manipulating the genetic structure of plants and animals. Drug of choice for acute gout, colchicine is also suggested for Bright’s disease, cholera, colic, skin ailments, and typhus.59
Appraisal of anti-gout potential of colchicine-loaded chitosan nanoparticle gel in uric acid-induced gout animal model
Published in Archives of Physiology and Biochemistry, 2022
Poonam Parashar, Ifrah Mazhar, Jovita Kanoujia, Abhishek Yadav, Pranesh Kumar, Shubhini A. Saraf, Sudipta Saha
Colchicine is a naturally occurring alkaloid extracted from the flowers of Autumn crocus Colchicum autumnale commonly known as meadow saffron. It is an anti-inflammatory drug which is widely used in the treatment of gouty arthritis (Dalbeth et al. 2014). Colchicine acts by reducing lactic acid production via leukocytes, which results in lowering uric acid deposition as well as decrease inflammatory response. In spite of being the most effective and fastest acting drug against gouty arthritis, colchicine is considered as last alternative in gout therapy due to its severe adverse effects associated with enteral and parenteral routes of administration (Wortmann 2002, Chilappa et al. 2010). The most dreadful effects comprises of bone marrow depression leading to anaemia, polyneuropathy subsequent to kidney failure and hallucinations (Khalil et al. 2014). In addition to that, a special consideration for dose adjustment is required among geriatric and paediatric patient. Oral administration further faces the problem of first pass hepatic metabolism resulting in reduced bioavailability (Nascimento et al. 2009, Shen et al. 2011). Intravenous administration of colchicine leads to problems like tissue necrosis, cytopenias etc. (Bonnel et al. 2002). Thus these drawbacks need to be addressed and nanoparticulate system could be one of the promising approach.
Targeting inflammation in diabetic nephropathy: a tale of hope
Published in Expert Opinion on Investigational Drugs, 2018
Juan Antonio Moreno, Carmen Gomez-Guerrero, Sebastian Mas, Ana Belen Sanz, Oscar Lorenzo, Marta Ruiz-Ortega, Lucas Opazo, Sergio Mezzano, Jesus Egido
Colchicine is a plant-derived alkaloid (colchicum autumnale), inexpensive and potent anti-inflammatory drug approved for acute use in patients with gout and chronic use in patients with Familial Mediterranean Fever with limited side-effects at low doses. Contrasting to therapies inhibiting single inflammation molecules, Colchicine is an agent with multiple targets, inhibiting tubulin polymerization, cellular adhesion molecules and inflammatory chemokines. Colchicine may also have direct anti-inflammatory effects by inhibiting inflammasome and pro-inflammatory cytokines. Recent works highlighted the anti-inflammatory potential of colchicine in the treatment of cardiovascular diseases. In patients with coronary disease colchicine 0.5 mg daily reliably reduced cardiovascular events [127]. The promise of low dose colchicine in patients with coronary disease is being explored in two phase III trials. The LoDoCo2 study was designed to examine its effects in approximately 5,000 patients with stable coronary disease (LoDoCo2 Trial at http://www.anzctr. org.au) and the COLPOT study with 4,500 patients to determine its effects in patients with recent acute coronary syndromes (https://clinicaltrials.gov/ct2/show/NCT02551094).
The Results of Interferon-Alpha Treatment in Behçet Uveitis
Published in Ocular Immunology and Inflammation, 2020
Hilal Eser-Ozturk, Yuksel Sullu
Before IFN-α therapy, patients were treated with at least one conventional immunosuppressive agent. The treatment regimens included AZA+cSA+CS in14 patients, AZA+cSA in six patients, AZA+CS in two patients, cSA+CS in two patients, and AZA only in one patient. Indications of IFN-α treatment were the ineffectiveness of conventional agents in 21 patients, intolerance of conventional treatment in two patients, and refractory macular edema in two patients. Twenty eyes had uveitis attack and 15 eyes had macular edema at the initiation. Colchicum dispert was added to the treatment in seven patients because of ongoing oral ulcers and/or skin lesions.