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Case 3.4
Published in Monica Fawzy, Plastic Surgery Vivas for the FRCS(Plast), 2023
Clindamycin, on the other hand, is not affected by the stage of bacterial growth and can switch off exotoxin production even in stationary phase organisms, as well as inhibit M-protein synthesis, thus promoting phagocytosis, decreasing toxin production, and preventing septic shock. In addition, it has a broader cover with some anaerobic cover.
Bacterial vaginosis in pregnancy: Evidence-based approaches
Published in Hung N. Winn, Frank A. Chervenak, Roberto Romero, Clinical Maternal-Fetal Medicine Online, 2021
James A. McGregor, Michael W. McCullough
Clindamycin is also an effective treatment for bacterial vaginitis, as well as its associated microflora, including some genital mycoplasmas. Greaves and coworkers (69) examined 49 women 7 to 10 days following completion of a 7-day course of oral clindamycin, 300mg twice daily, and demonstrated a cure rate of 94% for bacterial vaginosis. McGregor and associates (56) examined 194 pregnant women and found a 92% cure rate 2 to 4 weeks post-treatment (56). Oral treatment with clindamycin may be used throughout pregnancy, including the first trimester; it provides resolution of bacterial vaginosis equivalent to that of oral metronidazole.
Clindamycin
Published in Anton C. de Groot, Monographs in Contact Allergy, 2021
Clindamycin is a semisynthetic broad-spectrum antibiotic produced by chemical modification of the parent compound lincomycin. This agent dissociates peptidyl-tRNA from the bacterial ribosome, thereby disrupting bacterial protein synthesis. Clindamycin is indicated for the treatment of serious infections caused by susceptible anaerobic bacteria, including Bacteroides spp., Peptostreptococcus, anaerobic streptococci, Clostridium spp., and microaerophilic streptococci. The antibiotic may be useful in polymicrobial infections such as intra-abdominal or pelvic infections, osteomyelitis, diabetic foot ulcers, aspiration pneumonia and dental infections. Another use of clindamycin is vaginally to treat vaginosis caused by Gardnerella vaginosa. Clindamycin reduces the toxin-producing effects of S. aureus and S. pyogenes and as such, may be particularly useful for treating necrotizing fasciitis. In topical preparations, clindamycin is widely used in the treatment of inflammatory acne vulgaris (1).
Comparison of clinical efficacy of three different dentin matrix biomaterials obtained from different devices
Published in Expert Review of Medical Devices, 2023
Robert Dłucik, Bogusława Orzechowska-Wylęgała, Daniel Dłucik, Domenico Puzzolo, Giuseppe Santoro, Antonio Micali, Barbara Testagrossa, Giuseppe Acri
The study was conducted between September 2018 and January 2022 in Dłucik Dental Clinic, Katowice, Poland. Seventy patients were included in the study [43 females and 27 males; aged 22–77 years; mean age ± standard deviation (SD): 49.8 ± 14.3 years]. Inclusion criteria for the study were as follows: bone loss from cyst removal, two wall defects in most cases, three wall defects – patients for bone blocks, alveolar atrophy in periodontitis, extractions performed long time before, extractions of impacted teeth, and sinus lift procedures. Exclusion criteria were as follows: systemic diseases or metabolic bone disorders that could affect the healing process (e.g. uncontrolled diabetes mellitus, hyperthyroidism), cigarette smoking, chemotherapy, radiation therapy, bisphosphonates or corticosteroids treatment, pregnancy, and odontogenic acute inflammation near the surgical site. The follow-up time was 4–36 months. Our study presents the following limitations: it was not possible to control some clinical variables, such as bone graft site conditions (wall defect or amount of thread exposure) and location of bone graft (sinus graft, horizontal or vertical ridge augmentation); the aforementioned drawbacks might have introduced a bias for the objective evaluation of the clinical outcomes. Before the procedure, all patients underwent professional dental hygienization and were administered orally with clindamycin 0.6 g. In case of allergy to clindamycin, patients received amoxicillin/clavulanic acid 1 g.
Prolonged postoperative antibiotic administration reduces complications after medial thigh lift
Published in Journal of Plastic Surgery and Hand Surgery, 2022
J. Weber, Z. Kalash, F. Simunovic, B. Bonaventura
There were no side-effects of clindamycin noted in this study, such as allergic reaction or diarrhea, and all patients completed the two-week course of antibiotics. While fully aware of the undesirable effects, such as acquired antibiotic resistance, we believe that patients undergoing MTL surgery may benefit from prolonged antibiotic administration. In these patients, there is a high (possibly 100%) rate of subclinical wound breakdown in the early postoperative period, which can lead to deep tissue infections. Clindamycin is a reasonable choice as it has high tissue and fluid concentrations after oral intake, excellent tissue penetration and is effective against Gram-positive aerobe bacteria, such as staphylococcus and various streptococcus strains, as well as against anaerobic bacteria [31]. The optimal time of antibiotic administration needs to be further evaluated.
Nanotechnology-based formulations toward the improved topical delivery of anti-acne active ingredients
Published in Expert Opinion on Drug Delivery, 2021
Ana Cláudia Paiva-Santos, Filipa Mascarenhas-Melo, Sara Cabanas Coimbra, Kiran D. Pawar, Diana Peixoto, Raquel Chá-Chá, André RTS Araujo, Célia Cabral, Selmo Pinto, Francisco Veiga
Topical treatment is used as the first choice in mild to moderate situations of acne, including retinoids, benzoyl peroxide (BENP), azelaic acid (AZA), topical antibiotics, and combined therapy. Topical retinoids, as adapalene (ADA), tretinoin (TRE), and isotretinoin (ITR), are used as first-line therapy for primary acne lesions [15–17]. Nevertheless, those molecules evidence side effects, as erythema, eczematous irritation, skin peeling, dryness, and photosensitivity [18–20]. For inflammatory lesions, BENP is recommended since it has a bactericidal effect. However, BENP can cause irritant dermatitis with dryness, erythema, and peeling as side effects [12,15]. AZA has an anti-inflammatory effect and reduces the formation of comedones. Still, it can cause some photosensitivity, skin irritation, and redness [10,12]. Clindamycin (CLY), erythromycin (ERY), and tetracycline (TEY) are effective topical antibiotics used to treat mild to moderate acne, but can cause skin irritation [15].