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Marine Chondroitin Sulfate and Its Potential Applications
Published in Se-Kwon Kim, Marine Biochemistry, 2023
Chondroitin sulfate is a substance that is already present in the human body. This substance is believed to have a function to draw water and nutrients into human cartilage so that human cartilage remains healthy and supple (Joseph, 2021). The use of this substance is usually aimed at overcoming health problems as therapeutic agents such as pain in the joints and is also commonly used as an antithrombotic, an ischemic heart disease treatment, and an extravasation therapy agent along with hyperlipidemia (Archiando, 2020). The diversity of species and tissues causes chondroitin sulfate to have a heterogeneous structure and physico-chemical profile, which is responsible for the various and specific activities of this macromolecule (Volpi, 2019). The Indonesian Agency for Drug and Food Control through the decree of HK.00.05.23.3644 of 2004 stipulates that the maximum limit of chondroitin sulfate that can be consumed from dietary supplements is 1200 mg per day.
Applications of Marine Biochemical Pathways to Develop Bioactive and Functional Products
Published in Se-Kwon Kim, Marine Biochemistry, 2023
Toni-Ann Benjamin, Imran Ahmad, Muhammad Bilal Sadiq
GlcN and chondroitin sulfate are commonly used to treat pain and inflammation associated with osteoarthritis. Chondroitin sulfate exhibits antiarthritic activity and has been shown to reduce joint pain as well as enhance joint mobility. Biolane is a GAG-metalloprotease product and is utilized for normal tissue remodeling (Mutalipassi et al., 2021).
Glycosaminoglycans
Published in Luke R. Bucci, Nutrition Applied to Injury Rehabilitation and Sports Medicine, 2020
In several large clinical trials, as well as a study on atherosclerosis lasting for 6 years, there have been no major side effects attributed to oral CS at doses of 1.5 to 10 g/d.1206,1239 Less than 1% of patients had to cease taking CS. When injected, stomach upset and a few skin rashes were seen when side effects did occur. Oral administration of CS led to only very minor, if any, changes in coagulant profiles. Therefore, the ability of chondroitin sulfates to affect thrombus formation in vitro is not encountered in vivo. Most subjects given CS were diseased, with either atherosclerosis or degenerative joint diseases. Many of these subjects were also taking other anticoagulant therapy, including coumadin, with no apparent additive toxicity.1204 Thus, purified chondroitin sulfates administered orally appear to have almost no adverse side effects.
Assessment of pharmacy students’ knowledge, attitude, and practice toward herbal dietary supplements
Published in Journal of American College Health, 2022
Sarah A. Nakhal, Souraya A. Domiati, Mohamed E. K. Amin, Abdalla M. El-Lakany
Fish oil or Omega-3 is one of the most commonly consumed dietary supplements that provides many health benefits, including protection against a number of diseases such as cardiovascular, eye, and mental diseases, aids in weight loss, and reduce inflammation. Another consumed dietary supplement is fiber or psyllium used as a bulk-forming laxative. Furthermore, cranberry used for treating or preventing urinary tract infection (UTI), improving heart health, fighting age-related damage, and supporting the digestive system. Glucosamine and chondroitin are used for the treatment of osteoarthritis, despite the proof that they are no more effective than placebo in delaying the progression of cartilage loss in patients with moderate-to-severe knee osteoarthritis.14 Indeed, in the current study, these 5 herbal products were most frequently used by pharmacy students. This can be correlated by the fact that students refer mostly to the Internet (56%) as a source of information due to easy accessibility. In fact, according to the finding of Alhomoud et al.,6 the Internet carries a vast range of information, resources, and services. Textbooks accounted for the lowest percentage, although they are the most trusted source of information.
Shark Cartilage Supplement Labeling Practices and Compliance with U.S. Regulations
Published in Journal of Dietary Supplements, 2021
Rachel B. Isaacs, Rosalee S. Hellberg
Global demand for shark products increased over 40% from 2000 to 2012 (Dent and Clarke 2015). This has been attributed in part to popular media, such as the book Sharks Don't Get Cancer: How Shark Cartilage Could Save Your Life (Lane and Comac 1992), claiming that shark cartilage is a natural anti-carcinogenic and anti-inflammatory substance. In the year 2000, two U.S. companies were charged with making false and unsubstantiated claims about the efficacy of a shark cartilage product and a skin cream product, which were being deceptively marketed to consumers as cancer treatments (FTC 2000). Shark cartilage also has been reported to contain chondroitin sulfate and consumers often purchase these supplements for arthritic relief (Imada et al. 2010). Previous research discovered mislabeling of the contents in shark cartilage supplements (Hellberg et al. 2019), which raises concerns regarding other aspects of the product label. However, there is currently a lack of peer-reviewed information on whether shark cartilage supplement labels are compliant with U.S. regulations.
Bridging pharmacotherapy and minimally invasive surgery in interstitial cystitis/bladder pain syndrome treatment
Published in Expert Opinion on Pharmacotherapy, 2018
Athanasios E. Dellis, Athanasios G. Papatsoris
At present, the only US Food and Drug Administration (FDA)-approved treatment options include PPS orally administered and intravesical dimethyl sulfoxide (DMSO). On the contrary, according to the EAU Guidelines there is insufficient evidence to recommend the use of DMSO [5], while in Europe there are several formulations of chondroitin sulfate (CS) available commercially for IC/BPS intravesical therapy [11]. The main drawback of oral therapies is that only 1–3% of the drug reaches the bladder [12] and in case of intravesical therapies, there is a need for intermittent catheterizations (CISC) which might be painful and bear the risk of UTI, although they establish high concentrations with few systemic side effects [13]. Especially regarding CISC, since the use of 100 U of BTX to treat IC/BPS, only a very low percentage (up to 2%) of patients either suffer from urine retention or need CISC [14].