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Recent Cannabinoid Delivery Systems
Published in Betty Wedman-St Louis, Cannabis as Medicine, 2019
Natascia Bruni, Carlo Della Pepa, Simonetta Oliaro-Bosso, Daniela Gastaldi, Franco Dosio, Enrica Pessione
NLC have recently been proposed for administration as a dosage form for nasal delivery. Nanospheres of 200 nm diameter, composed of either cetyl palmitate or glyceryl dibehenate and loaded with THC, were obtained. In vitro mucoadhesion evaluations have revealed that cationic NLC formulations (obtained via the addition of cetylpyridinium chloride) should have high mucoadhesiveness properties [123]. The solid matrix of the NLC was found to have a stabilizing effect on THC. Indeed, 91% of the THC was unaltered after 6 months storage at 4°C. About 1.7 mg THC is administered with one spray of the 0.25% THC-loaded NLC formulation in each nostril. This amount was close to the THC amounts obtained from the oromucosal formulation in a study by Johnson et al. [124].
Advanced Formulation Techniques Including Innovative Materials
Published in Heather A.E. Benson, Michael S. Roberts, Vânia Rodrigues Leite-Silva, Kenneth A. Walters, Cosmetic Formulation, 2019
Bozena Michniak-Kohn, Tannaz Ramezanli, Frank Romanski, Cliff Milow, Kishore Shah
Natural claims and products are no longer a niche market confined to small boutiques and health food stores. Many global companies have added natural lines to their products or minimally natural claims to existing products. National retailers such as Walmart and Target are demanding sustainability trails back to the origin of the feedstock and manufacturing details. Ingredients in personal care are under increased scrutiny via NGOs such as the Environmental Working Group or government watch lists like Proposition 65 in California. One ingredient that is becoming more scrutinized is ethylene oxide, which very generally speaking is used to make oils and waxes more water-soluble. A vast majority of emulsifiers and surfactants in the personal care industry are ethoxylated. BASF recognized the need for natural-based emulsifiers and added to its list of 274 Natural Product Association–certified ingredients with the launch of an exclusive sucrose-based, non-ethoxylated emulsifier: Emulgade Sucro Plus (INCI: sucrose polystearate and cetyl palmitate). This product can serve as a primary emulsifier at higher concentrations or the secondary in lower. It supports the formation of lamellar micelle structure (Figure 18.6 ), that is liquid crystals, which create a unique sensorial experience and have been suggested to lead to better penetration of active molecules. Emulgade Sucro Plus gives formulators a natural option to create luxurious emulsions with high-end consumer appeal.
Nanocarrier Technologies for Enhancing the Solubility and Dissolution Rate of Api
Published in Debarshi Kar Mahapatra, Sanjay Kumar Bharti, Medicinal Chemistry with Pharmaceutical Product Development, 2019
Ashwini Deshpande, Tulshidas S. Patil
These are biocompatible, biodegradable lipids which are solid at room and body temperature. The lipids can be used within the range of 5–40%. Examples include: Triglycerides (trimyristin, tripalmitin, tristearin).Polymers like soya phosphatidyl choline, PLGA, sodium alginate, chitosan, etc.Glyceryl monostearate (GMS) (Imwitor® 900).Glyceryl behenate (Compritol® 888 ATO, GeleolTM).Glyceryl palmitostearate (Precirol® ATO 5).Wax (cetyl palmitate).
Fabrication, optimization, and in vitro evaluation of docetaxel-loaded nanostructured lipid carriers for improved anticancer activity
Published in Journal of Liposome Research, 2020
Prateek Mathur, Swati Sharma, Shruti Rawal, Bhoomika Patel, Mayur M. Patel
DTX was procured from MedChem Express LLC, USA (Lot #: 27126, CAS # 114977–28-5) (99.93% purity). Softisan 154, Dynasan 118, and Dynasan 116 were received generously from Cremer Oleo GmbH & Co. KG, Hamburg, Germany. Compritol HD5 ATO, Compritol 888 ATO, Glyceryl monooleate (GMO), Geleol, Precirol® ATO 5, Plurol oleique CC 497, Maisine 35–1, and Labrafil M2125 CS were received generously from Gattefosse India Private Limited, Mumbai, India. Poloxamer 407, Poloxamer 188, Cremophor EL, Cremophor RH 40, and Solutol HS 15 were obtained as gift sample from BASF India Ltd., Mumbai, India. Vitamin E TPGS (D-a-tocopheryl polyethylene glycol 1000 succinate) was obtained as a gift sample from Antares Health Products Inc., Jonesborough, Tennessee. Oleic acid, stearylamine, stearic acid, Polysorbate 80, Polysorbate 20, Span® 80, and Span® 85 were procured from Central Drug House (Pvt) Ltd., New Delhi. PEG 4000 mono-stearate was obtained as gift sample from Mohini Organics Pvt. Ltd. Phospholipon® 90 G, soy lecithin (Source: soy), and Phospholipon® 90 H were obtained as gift samples from Lipoid, Germany GmbH. Cetyl palmitate was procured from Croda India, Mumbai, India. All other chemicals and reagents used were of analytical reagent grade.
Formulation, optimization, and characterization of rifampicin-loaded solid lipid nanoparticles for the treatment of tuberculosis
Published in Drug Development and Industrial Pharmacy, 2018
Nimitt V. Chokshi, Hiren N. Khatri, Mayur M. Patel
Rifampicin (RIF) was obtained as a kind gratis supply from Lupin pharmaceuticals Inc., Aurangabad, India. Compritol 888 ATO was kindly donated by Gattefosse India Pvt. Ltd., Mumbai, India. Stearic acid and stearylamine were obtained from Himedia laboratories, Mumbai, India. Dynasan 118, Dyansan 116, Dynasan 114 and Softisan 154 were obtained as gift samples from CremerOleo, Germany. Glyceryl monostearate was obtained as a gift sample from Hallstar. Cetyl Palmitate (Brand: Crodamol CP) was obtained as a gift sample from Croda, Mumbai, India. Polysorbate 20, polysorbate 80, Span® 20 and Span® 80 were purchased from Central Drug House Pvt. Ltd., New Delhi, India. Cremophor RH 40, Cremophor EL, poloxamer 188, poloxamer 407 and Solutol HS 15 were obtained as gift samples from BASF India Ltd., Mumbai, India. Phospholipon® 90 G, Phospholipon® 90 H, Lipoid® S 75 and soy lecithin (Source: soy) were obtained as gift samples from Lipoid, Germany GmbH. Mannitol was purchased from Central Drug House Pvt. Ltd., New Delhi, India. Sephadex G-50 (coarse grade) was purchased from MP Biomedicals, USA. All other chemicals were of analytical reagent grade and the solvents were of HPLC grade.
Process, optimization, and characterization of budesonide-loaded nanostructured lipid carriers for the treatment of inflammatory bowel disease
Published in Drug Development and Industrial Pharmacy, 2018
Gurpreet Kaur Sinhmar, Neel N. Shah, Nimitt V. Chokshi, Hiren N. Khatri, Mayur M. Patel
Budesonide was received as a kind gift from Zydus Healthcare, Ahmedabad, India. Dynasan 114, Dynasan 116, Dynasan 118, Softisan 154 was obtained as gift sample from Cremer Oleo GmbH & Co. KG, Hamburg, Germany. Compritol 888 ATO, Glyceryl monooleate, Geleol, Gelucire 50/13, Plurol oleique CC 497, Labrafac WL 1349, Labrafil M2125 CS was received as a gift sample from Gattefosse India Private Limited, Mumbai, India. Eudragit® S100 was received as gift sample from Evonik Röhm GmbH, Darmstadt, Germany. Poloxamer 188, Poloxamer 407, Solutol HS 15, Cremophor RH 40, Cremophor EL was obtained as gift sample from BASF India Ltd., Mumbai, India. Cetyl palmitate was procured from Croda India, Mumbai, India. Oleic acid, Stearic acid, Stearylamine, Polysorbate 20, Polysorbate 40, and Polysorbate 80 were purchased from Central Drug House (Pvt) Ltd., New Delhi. D-mannose was purchased from Otto Chemie Pvt Ltd., Mumbai, India. Other excipients used were of standard pharmaceutical grade. All chemicals and reagents used were of analytical reagent grade.