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Herbs with Antidepressant Effects
Published in Scott Mendelson, Herbal Treatment of Major Depression, 2019
A number of complex terpenoids, the hericenones and erinacines, appear unique to Hericium erinaceus. These molecules are believed to hold the mushroom’s ability to stimulate neuronal growth.2 Other substances isolated from Hericium erinaceus include ergosterol peroxide, cerevisterol, inoterpene, astradoric acid, betulin, oleanolic acid, ursolic acid, and hemisceramide.3 Flavonoids common to many medicinal herbs, 4-hydroxybenzoic acid, syringic acid, 4-coumaric acid, and ferulic acid, have also been identified in Hericium erinaceus.4
Recent advances towards natural plants as potential inhibitors of SARS-Cov-2 targets
Published in Pharmaceutical Biology, 2023
Zhouman He, Jia Yuan, Yuanwen Zhang, Runfeng Li, Meilan Mo, Yutao Wang, Huihui Ti
Gingerol, the main spicy component of ginger, can be used as a medicinal food derivative (Rahman F et al. 2021). It also contains similar pharmacophores as nelfinavir and might bind to 3CLpro, based on MD (Khaerunnisa et al. 2020). By performing a virtual screen for phytochemicals, Wu C et al. (2020) proposed that in-house natural products might serve as potential 3CLpro inhibitors. For example, andrograpanin, phyllaemblinol, oleanolic acid, deacetylcentapicrin, betulonal, andrographiside, gnidicin, platycodin D, (S)-(1S,2R,4aS,5R,8aS)-1-formamido-(1S,2R,4aS,5R,8aS)-1-formamido-1,4a-dimethyl-6-methylene-5-([E]-2-[2-oxo-2,5-dihydrofuran-3-yl]ethenyl) decahydronaphthalen-2-yl 5-([R]-1,2-dithiolan-3-yl) pentanoate, (1S,2R,4aS,5R,8aS)-1-formamido-1,4a-dimethyl-6-methylene-5-([E]-2-[2-oxo-2,5-dihydrofuran-3-yl]ethenyl) decahydronaphthalen-2-yl 2-nitrobenzoate, (S)-(1S,2R,4aS,5R,8aS)-1-formamido-1, 4a-dimethyl-6-methylene-5-([E]-2-[2-oxo-2,5-dihydrofuran-3-yl]ethenyl) decahydronaphthalen-2-yl-2-amino-3-phenylpropanoate, 2-([1R,5R,6R,8aS]-6-hydroxy-5-[hydroxymethyl]-5,8a-dimethyl-2-methylenedecahydronaphthalen-1-yl)ethyl benzoate, 2β-hydroxy-3,4-seco-friedelolactone-27-oic acid, cerevisterol, kouitchenside I, and stigmast-5-en-3-ol (sitosterol) might have high binding affinities for 3CLpro. These natural small-molecule compounds may be potential therapeutic candidates for SARS-CoV-2.