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New Trends in the Treatment of Infectious Diseases
Published in M. T. Labro, Host Defense and Infection, 1994
Recently, a molecule belonging to the “third-generation” cephalosporins, cefodizime, has been reported to be a good candidate. Why this aminothiazolyl is considered the forerunner of a new class of antibacterial drugs is the subject of the last chapter in this review.
Research on the relationship between cephalosporin structure, solution clarity, and rubber closure compatibility using volatile components profile of butyl rubber closures
Published in Drug Development and Industrial Pharmacy, 2019
Xiao-Meng Chong, Xin Dong, Shang-Chen Yao, Chang-Qin Hu
All kinds of cephalosporins for injection were obtained from national evaluation inspection in China. Except for some samples that did not meet the requirement for clarity of reconstituted solutions provided in Chinese Pharmacopoeia, all the other items qualified. The cephalosporins for injection included seven batches of cefodizime sodium for injection from one manufacturer. Among the seven batches, the clarity of three batches did not meet the requirement of clarity of solution provided in Chinese Pharmacopoeia. Among the six batches of ceftriaxone sodium for injection from two different manufacturers, the clarity of three batches did not meet the requirement of clarity of solution provided in Chinese Pharmacopoeia. Although the clarity of seventeen batches of cefpiramide sodium for injection from six different manufacturers met the requirement of clarity of solution, the extent of turbidity of each batch was different when measured with a nephelometer. The clarity of all four batches of cefamandole nafate for injection from two different manufacturers met the requirement of clarity of solution; however, the extent of turbidity of each batch was different when measured with a nephelometer. The clarity of one batch of cefmenoxime for injection and one batch of cefoperazone sodium for injection met the requirement of clarity of solution.