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Monographs of fragrance chemicals and extracts that have caused contact allergy / allergic contact dermatitis
Published in Anton C. de Groot, Monographs in Contact Allergy, 2021
Carvone is used as a flavoring for alcoholic beverages and foodstuffs, in personal care products, perfumery and in soaps. L-Carvone is one of several substances found in oxidized D-limonene (26), and there are methods to produce it from D-limonene synthetically (30,31). L-Carvone is produced in larger quantities than D-carvone and is mainly used in oral hygiene products such as toothpaste and mouthwash. Other uses include or have included: as pesticide, plant growth regulator, feed additive for pigs and veterinary use (U.S. National Library of Medicine).
Biotransformation of Monoterpenoids by Microorganisms, Insects, and Mammals
Published in K. Hüsnü Can Başer, Gerhard Buchbauer, Handbook of Essential Oils, 2020
Yoshiaki Noma, Yoshinori Asakawa
Carvone occurs as (+)-carvone (93), (−)-carvone (93′), or racemic carvone. (S)-(+)-Carvone (93) is the main component of caraway oil (ca. 60%) and dill oil and has a herbaceous odor reminiscent of caraway and dill seeds. (R)-(−)-Carvone (93′) occurs in spearmint oil at a concentration of 70%–80% and has a herbaceous odor similar to spearmint (Bauer et al., 1990).
Carvone suppresses oxidative stress and inflammation in the liver of immobilised rats
Published in Archives of Physiology and Biochemistry, 2023
Masoumeh Asle-Rousta, Rahim Amini, Safieh Aghazadeh
Several natural terpenoids have been shown to have a hepatoprotective effect (de Cássia da Silveira e Sá et al.2013). Carvone (5-isopropenyl-2-methyl-2-cyclohexenone), a member of the monoterpene family, is abundant in many plants, including caraway and spearmint (de Carvalho and da Fonseca 2006). Researches have shown that carvone possesses various pharmacological effects such as anti-inflammatory, antitumor, antihepatotoxic, antimicrobial, and fungicidal activities (Aydın et al.2015, Moro et al. 2017). The antioxidant effects of carvone have been evaluated and published by several independent groups (Elmastaş et al.2006, Vinothkumar et al.2013, Rajeshwari and Raja 2015). Moreover, it has been found to inhibit the production of pro-inflammatory mediators such as TNF-α and IL-6 in lipopolysaccharide (LPS) -induced acute lung injury and high-fat diet-induced obesity mice (Alsanea and Liu 2017, Tang et al.2017).
Citronellol, an Acyclic Monoterpene Induces Mitochondrial-Mediated Apoptosis through Activation of Proapoptotic Factors in MCF-7 and MDA-MB-231 Human Mammary Tumor Cells
Published in Nutrition and Cancer, 2021
Jayaganesh Rajendran, Pugalendhi Pachaiappan, Rajakumar Thangarasu
Excess ROS production in the system causing oxidative stress, which damage to cell component, particularly DNA, leading to chronic diseases like cancer (20). However, the previous study reported that a high level of ROS induces apoptosis by triggering proapoptotic signaling molecules (21). In this study, CT induces apoptosis by increasing the ROS level in a dose-dependent manner, by exerts prooxidant effect in carcinoma cells. Comet assay parameters relating to DNA damage clearly indicate the oxidative DNA damage due to the pro-oxidant role of CT. DNA damage caused by L-carvone was apparent from the increased tail moment in comet assay, which might be due to oxidative stress in MCF-7 and MDA-MB-231 cells (29). L carvone and citronellol are belong to same family of terpenoid chemical which are naturally found in essential oil.
Carvone protects against paclitaxel-induced retinal and optic nerve cytotoxicity: a histopathological study
Published in Cutaneous and Ocular Toxicology, 2019
Emine Cinici, Nilay Dilekmen, Zerrin Kutlu, Busra Dincer, Ozkan Cinici, Hilal Balta, Ilknur Calık
Bioactive compounds from plants are extensively studied for their capacity to protect cells from damage which is induced by OS. Carvone (CVN) (5-isopropenyl-2-methyl-2-cyclohexenone) is a natural monocyclic monoterpene which is found naturally in many essential oils8. It is most abundant in the oils from seeds of caraway (Carum carvi L. Umbelliferae), spearmint (Mentha spicata), and dill8. CVN forms two enantiomers: R-(–)-CVN, or L-CVN and its mirror image, S-(+)-CVN, or D-CVN 9. There is accumulating evidence indicating that CVN has impressive health-promoting effects, among them are antioxidant, antitumor, antiinflammatory, antimicrobial, and anticonvulsant activities10. To our knowledge, no research exists addressing the possible protective effects of CVN focusing primarily on retinal and/or optic nerve tissues. This study aims to evaluate whether CVN has any protective effect against OS-based cytotoxicity induced by PTX in retinal and optic nerve tissues histopathologically.