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Medicinal Plants of Central Asia
Published in Raymond Cooper, Jeffrey John Deakin, Natural Products of Silk Road Plants, 2020
Farukh S. Sharopov, William N. Setzer
Berberis L. species (Berberidaceae). The Kyrgyz people take a decoction of the dried fruits of Berberis heterobotrys E.L. Wolf for fever (Soelberg and Jäger, 2016). In Tajikistan, the roots of Berberis integerrima Bunge (synonym Berberis oblonga (Regel) C.K. Schneid.) are used to treat wounds, bone fractures, rheumatism, radiculitis, heart pain, and stomach aches; a leaf decoction is used to treat kidney stones; an infusion of the flowers is used to treat tuberculosis, chest pains, and headaches; an infusion of the fruits is used to treat constipation and wounds (Zaurov et al., 2013). In Kyrgyzstan, a decoction of the roots and bark of B. integerrima is used to treat bone fractures (Pawera et al., 2016). The bark of Berberis vulgaris L. is used to treat skin conditions (wounds, skin irritations, allergic rashes, and dermatitis) (Mamedov et al., 2004). Isoquinoline alkaloids (berberine, palmatine, jatrorrhizine, berbamine, oxyacanthine = hydroxyacanthine, isocorydine, Figure 4.4) are found in the fruits, roots, and bark of Berberis spp. (Bhardwaj and Kaushik, 2012; Sharopov and Setzer, 2018).
Atlas of Autofluorescence in Plant Pharmaceutical Materials
Published in Victoria Vladimirovna Roshchina, Fluorescence of Living Plant Cells for Phytomedicine Preparations, 2020
Victoria Vladimirovna Roshchina
Barberry or European barberry, Berberis vulgaris L., from the family Berberidaceae contains a large number of phytochemical materials. Extracts from the roots and leaves of Berberis vulgaris may have anticancer, anti-inflammatory, antioxidant, antidiabetic, antibacterial, analgesic, antinociceptive, and hepatoprotective effects (Golovkin et al. 2001; Duke 2002; Murav’eva et al. 2007) It includes more than 30 alkaloids, ascorbic acid, vitamin K, several triterpenoids, and about 10 phenolic compounds (Rahimi-Madiseh et al. 2017). Active matter of the plant is thought to be mainly alkaloids such as berberine, because this is the predominant active medicinal agent. It is possible to use different organs of B. vulgaris, especially fruit, to develop new drugs.
Mode of Action of Selected Botanicals That Lower Blood Glucose
Published in Robert Fried, Richard M. Carlton, Type 2 Diabetes, 2018
Robert Fried, Richard M. Carlton
Berberine was first isolated from Berberis vulgaris, also known as common barberry. European barberry, or simply barberry, is a shrub in the genus Berberis. It produces edible but sharply acidic berries that people in many countries eat as a tart and refreshing fruit. This compound has multiple functions ranging from inflammation inhibition to reduction of metabolic syndrome and related activities (Imanshahidi, and Hosseinzadeh. 2008).
The effect of co-administration of berberine, resveratrol, and glibenclamide on xenobiotic metabolizing enzyme activities in diabetic rat liver
Published in Drug and Chemical Toxicology, 2022
Azra Bozcaarmutlu, Canan Sapmaz, Ömer Bozdoğan, Aysel Kükner, Leyla Kılınç, Salih Tunç Kaya, Oğulcan Talat Özarslan, Didem Ekşioğlu
There are several plant-derived substances in the form of dietary supplements in drug stores. The effects of most of these products have not been well defined in the presence of a prescribed drug and metabolic disease. Berberine is a bioactive alkaloid found in the roots of many plants including Berberis vulgaris, Berberis aquifolium, Berberis aristata, Hydrastis Canadensis, Rhizoma coptidis, and Coptis chinensis (Chander et al. 2017, Chandirasegaran et al. 2018). It has been used in traditional Chinese medicine for centuries in the treatment of liver disorders, diarrhea, and gastroenteritis (Zhao et al. 2008). In addition to these properties, anti-tumor, anti-microbial, anti-HIV, anti-fungus, antioxidant, cholesterol lowering, and immunosuppressive effects of berberine have been shown (Gudima et al. 1994, Küpeli et al. 2002, Kim et al. 2003, Tran et al. 2003, Volleková et al. 2003, Kettmann et al. 2004, Kong et al. 2004, Racková et al. 2004, Cheng et al. 2006). It is also known that berberine has a hypoglycemic effect (Tang et al. 2006).
The effect and safety of Berberine on polycystic ovary syndrome: a systematic review
Published in Journal of Obstetrics and Gynaecology, 2021
Firoozeh Mirzaee, Parisa Razmjouei, Hadis Shahrahmani, Fahime Vafisani, Mona Najaf Najafi, Masumeh Ghazanfarpour
The systematic review of literature is based on instructions provided by the PRISMA statement (Moher et al. 2015). For this purpose, we systematically searched electronic databases of MEDLINE, Web of Science, Scopus, and Cochrane Central Register of Controlled Trials (CENTRAL) from the base to July 1th, 2019. The search was based on key terms such as Berberine OR Berberis OR Berberis vulgaris OR Barberry OR Oregon-grape) AND (PCO OR PCOS OR Polycystic ovary disease OR Polycystic ovary syndrome). No language restrictions were applied. The reference list of selected studies and relevant systematic reviews was searched manually to find relevant studies. Additional papers were sought in published reviews and the reference lists of papers. Disagreements between reviewers were settled by consulting a third author.
The protective effect of berberine against lipopolysaccharide-induced abortion by modulation of inflammatory/immune responses
Published in Immunopharmacology and Immunotoxicology, 2018
Maryam Mahdavi Siuki, Nafiseh Fazel Nasab, Elham Barati, Maryam Nezafat Firizi, Tahereh Jalilvand, Hasan Namdar Ahmadabad
Berberine is an isoquinoline derivative alkaloid isolated from many medicinal herbs, such as Berberis vulgaris (barberry), Hydrastis canadensis (goldenseal), Rhizoma coptidis (Huanglian), Berberis aristata (tree turmeric), and Cortex phellodendri (Huangbai). It has been widely used in traditional medicine for the treatment of many complications. In the recent decades, many pharmacological activities of berberine including anti-cancer effects [14], LDL-lowering agent [15], anti-microbial effects, an anti-diarrheal drug [14], anti-diabetic property [16], and prevention of cardiovascular disease [15] have been reported. Furthermore, berberine has anti-inflammatory effects and can improve inflammatory diseases, such as inflammatory bowel disease (IBD), colitis [17], and neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and Huntington’s disease [18].