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Azadirachta indica (Neem) and Berberis aristata (Indian Barberry)
Published in Azamal Husen, Herbs, Shrubs, and Trees of Potential Medicinal Benefits, 2022
Swati T. Gurme, Devashree N. Patil, Suchita V. Jadhav, Mahendra L. Ahire, Pankaj S. Mundada
Berberis aristata, or Indian barberry, is one of the plants used in different medicinal systems like Ayurveda, homeopathy, Unani, Chinese, and allopathy for treatment of several ailments. It is a native plant of Himalaya and widely distributed from the Himalayan region to Sri Lanka, Bhutan, and hilly regions of Nepal. It is commonly called “Daru haldhi and Chitra” or tree turmeric (Mazumder et al., 2011). Nearly each part of this medicinal plant has medicinal importance. The Berberis has many useful applications in Indian and European systems for treatment of fever, eye diseases, jaundice, rheumatism, and kidney and gall bladder stones. Methanolic root extract shows the anti-inflammatory effect too. It is also used in snake and scorpion bite (Srivastava et al., 2015). Different alkaloids, flavonoids, phenols, lignin, steroids, vitamins, proteins, lipids, and carotenoids have been isolated from the Berberis plant species. The major bioactive compounds present in Berberis aristata are berberine, berbamine, palmatine, magnoflorine, jatrorrhizine, caffeic acid, quercetin, chlorogenic acid, meratin, and rutin (Chander et al., 2017; Basera et al., 2021).
Lessons to Be Learnt from Ayurveda
Published in D. Suresh Kumar, Ayurveda in the New Millennium, 2020
Prachi Garodia, Sosmitha Girisa, Varsha Rana, Ajaikumar B. Kunnumakkara, Bharat B. Aggarwal
Ayurvedic texts describe two complications of āmavāta – Hṛdayaviśuddhi and Hṛdgraha. The former represents the unclean state of the heart and the latter an impaired condition (Mithra 2019). The treatment for heart disease mentions the use of Arjuna for the first time by Vṛnda, and later by Cakrapāṇi Datta and Bhāvamiśra. All of them recommend the use of different bark powder formulations of Arjuna (Seth et al. 2013). The bark of Terminalia arjuna tree is extensively used in ayurvedic therapy for several cardiovascular diseases (Mahmood et al. 2010). The bark is demonstrated to have cardioprotective properties that range from positive inotropic, hypolipidemic, coronary vasodilatory and antioxidant effects to the initiation of stress protein in the heart of various animal models (Maulik and Katiyar 2010). Berberis aristata, the major source of alkaloid berberine, has also been an essential component of Ayurveda and traditional Chinese medicine for over 2000 years, due to its outstanding effects on cardiovascular disease (Feng et al. 2019).
Atlas of Autofluorescence in Plant Pharmaceutical Materials
Published in Victoria Vladimirovna Roshchina, Fluorescence of Living Plant Cells for Phytomedicine Preparations, 2020
Victoria Vladimirovna Roshchina
Barberry or European barberry, Berberis vulgaris L., from the family Berberidaceae contains a large number of phytochemical materials. Extracts from the roots and leaves of Berberis vulgaris may have anticancer, anti-inflammatory, antioxidant, antidiabetic, antibacterial, analgesic, antinociceptive, and hepatoprotective effects (Golovkin et al. 2001; Duke 2002; Murav’eva et al. 2007) It includes more than 30 alkaloids, ascorbic acid, vitamin K, several triterpenoids, and about 10 phenolic compounds (Rahimi-Madiseh et al. 2017). Active matter of the plant is thought to be mainly alkaloids such as berberine, because this is the predominant active medicinal agent. It is possible to use different organs of B. vulgaris, especially fruit, to develop new drugs.
A drift on liposomes to proliposomes: recent advances and promising approaches
Published in Journal of Liposome Research, 2022
Neha Dhiman, Jayrajsinh Sarvaiya, Poorti Mohindroo
Berberine, an isoquinoline alkaloid, extracted from plants (Berberis species), has a range of medicinal benefits including anti-tumor, anti-diabetic potency, but its low bioavailability (<1%) limits its use (Hahn and Ciak 1975, Guamán Ortiz et al.2014, Kumar et al.2015). Jia et al. prepared Berberine proliposome (Ber-PL) to overcome its low bioavailability issue and states the first efficient research in this area. The researcher and his co-workers utilized supercritical superfine particle producer apparatus for the preparation of Ber-PL via solution enhanced dispersion by supercritical CO2 (SEDS). The liposomes formed upon hydration resulted in average particle size of around 80 nm with neutral zeta potential. A faster drug release pattern was detected in PBS having 7.4 pH compared to buffer with pH 1.2, hence demonstrating an intestinal or plasma release affinity of active moiety. Moreover, the research group found that the Ber-PLs displayed 22.47 times greater oral bioavailability than raw berberine, and the mean residence time of berberine in plasma was increased from 6.82 to 10.83 h (approx.); hence, signified a promising strategy for poorly bioavailable drugs (Jia et al.2019).
The effect of co-administration of berberine, resveratrol, and glibenclamide on xenobiotic metabolizing enzyme activities in diabetic rat liver
Published in Drug and Chemical Toxicology, 2022
Azra Bozcaarmutlu, Canan Sapmaz, Ömer Bozdoğan, Aysel Kükner, Leyla Kılınç, Salih Tunç Kaya, Oğulcan Talat Özarslan, Didem Ekşioğlu
There are several plant-derived substances in the form of dietary supplements in drug stores. The effects of most of these products have not been well defined in the presence of a prescribed drug and metabolic disease. Berberine is a bioactive alkaloid found in the roots of many plants including Berberis vulgaris, Berberis aquifolium, Berberis aristata, Hydrastis Canadensis, Rhizoma coptidis, and Coptis chinensis (Chander et al. 2017, Chandirasegaran et al. 2018). It has been used in traditional Chinese medicine for centuries in the treatment of liver disorders, diarrhea, and gastroenteritis (Zhao et al. 2008). In addition to these properties, anti-tumor, anti-microbial, anti-HIV, anti-fungus, antioxidant, cholesterol lowering, and immunosuppressive effects of berberine have been shown (Gudima et al. 1994, Küpeli et al. 2002, Kim et al. 2003, Tran et al. 2003, Volleková et al. 2003, Kettmann et al. 2004, Kong et al. 2004, Racková et al. 2004, Cheng et al. 2006). It is also known that berberine has a hypoglycemic effect (Tang et al. 2006).
The protective effect of berberine against lipopolysaccharide-induced abortion by modulation of inflammatory/immune responses
Published in Immunopharmacology and Immunotoxicology, 2018
Maryam Mahdavi Siuki, Nafiseh Fazel Nasab, Elham Barati, Maryam Nezafat Firizi, Tahereh Jalilvand, Hasan Namdar Ahmadabad
Berberine is an isoquinoline derivative alkaloid isolated from many medicinal herbs, such as Berberis vulgaris (barberry), Hydrastis canadensis (goldenseal), Rhizoma coptidis (Huanglian), Berberis aristata (tree turmeric), and Cortex phellodendri (Huangbai). It has been widely used in traditional medicine for the treatment of many complications. In the recent decades, many pharmacological activities of berberine including anti-cancer effects [14], LDL-lowering agent [15], anti-microbial effects, an anti-diarrheal drug [14], anti-diabetic property [16], and prevention of cardiovascular disease [15] have been reported. Furthermore, berberine has anti-inflammatory effects and can improve inflammatory diseases, such as inflammatory bowel disease (IBD), colitis [17], and neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and Huntington’s disease [18].