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Nutritional and Dietary Supplementation during Pregnancy
Published in “Bert” Bertis Britt Little, Drugs and Pregnancy, 2022
Agents such as prochlorperazine, promethazine, chlorpromazine, and thiethylperazine may be associated with extrapyramidal side effects, manifested as dystonia, torticollis, and oculogyric crisis. If extrapyramidal effects occur, the unusual syndrome of adverse effects can be treated with diphenhydramine (Benadryl). Importantly, chlorpromazine may be associated with significant hypotension when given intravenously. Therefore, suppositories are the preferred route of administration.
Monographs of Topical Drugs that Have Caused Contact Allergy/Allergic Contact Dermatitis
Published in Anton C. de Groot, Monographs in Contact Allergy, 2021
Currently, contact allergy to diphenhydramine (better known under one of its trade names, Benadryl) is rarely reported. Nevertheless, it was stated to be a common cause of allergic contact dermatitis in the USA in the 1980s (15), although another American author, in 1983, presenting 3 patients sensitized to diphenhydramine, could find only a few other case reports (24). However, 2 series of 19 (26) and 12 (27) cases of diphenhydramine hydrochloride dermatitis had previously been reported from the United Kingdom (data cited in ref. 24). Diphenhydramine has also caused some cases of photocontact dermatitis (see the section ‘Photosensitivity’ below) and systemic contact dermatitis (12,25).
Whence the Drugs?
Published in Mickey C. Smith, E.M. (Mick) Kolassa, Walter Steven Pray, Government, Big Pharma, and the People, 2020
Mickey C. Smith, E.M. (Mick) Kolassa, Walter Steven Pray
Sometimes side effects can have positive results. Diphenhydramine (Benadryl) can cause drowsiness. That’s the reason so many other antihistamines can label themselves “non-drowsy”. This one was easy. Who wants to be drowsy? People who have trouble sleeping! Check the ingredients on your OTC sleep remedy. You’ll find it listed.
A Case Study on Differential Diagnosis of Episodic Left Arm Numbness
Published in The Neurodiagnostic Journal, 2021
About 10 minutes into the recording, the patient became drowsy, eliciting rhythmic, mid-temporal theta activity and alpha wave attenuation. Stage N2 sleep soon followed marked by occasional vertex sharp transients, background slowing and spindles. During sleep, a focal right centroparietal electrographic seizure occurred starting with delta waves, then a buildup of beta wave activity (13–14 Hz) and evolving into sharply contoured theta activity progressing back to delta waves with intermixed spikes. (Figures 2–5). The seizure lasted 1 minute and 21 seconds with no clinical correlation. The neurologist was notified, and the patient was converted to long-term video EEG monitoring. Only 4 hours were captured before the patient disconnected himself by pulling off the electrodes. During that time, he had 9 more electrographic seizures, all stereotypically arising from the right central, parietal and occipital regions with a few spreading to the left side. Each lasted 2–3 minutes and had no obvious clinical correlate, with clear speech and interaction through the ones where family or staff were in the room. An hour before self-disconnecting, he received an intravenous (IV) fosphenytoin infusion, which was halted due to the patient becoming unbearably itchy, which likely led to the self-disconnection. This information was relayed to the medicine team and alternate antiseizure medication was advised with a reorder of continuous video EEG. 50 mg of Benadryl was administered, and the pruritus subsided.
Post Marketing Safety of Plus CBD™ Products, a Full Spectrum Hemp Extract: A 2-Year Experience
Published in Journal of Dietary Supplements, 2020
Stephen M. Schmitz, Hector L. Lopez, Osvaldo Marinotti
The second serious AE involved a 64 year old female consumer who reported that she was treated in the emergency room after experiencing shortness of breath and tongue swelling following her fourth dose of sublingual PlusCBD™ Oil Peppermint liquid. Within minutes of taking the product, she felt a burning in her mouth and tongue and a sensation of throat closing. She went to the ER and was treated with IV Benadryl. She felt better “immediately” and was discharged after two hours. No other therapy was administered. She had purchased two bottles of the same product from the same store. One week after the symptoms resolved, she used the other bottle without incident. Although the customer responded promptly to IV therapy and remained in the ER for only two hours, the case is considered an important medical event as IV therapy was required urgently. This customer stated she is generally healthy with no prior history of allergic-type reactions. In addition, she has used PlusCBD™ soft gels for more than a year without incident. The initial presentation of this case is a hypersensitivity reaction, and the customer was treated as such. The quick response to IV Benadryl is puzzling, as antihistamines do not typically work immediately, as epinephrine does. The customer was able to take the second bottle of the same product without incident, making a hypersensitivity reaction less likely.
Persistent infection with Staphylococcus pseudintermedius in an adult oncology patient with transmission from a family dog
Published in Journal of Chemotherapy, 2020
L.D. Blondeau, J.E. Rubin, H. Deneer, R. Kanthan, B. Morrison, S. Sanche, C. Rypien, D. Dueck, G. Beck, J.M. Blondeau
Patient LW is a 47 year old female patient diagnosed with metastatic rectal cancer with extensive metastasis to the liver and mesenteric lymph nodes. She had a right hepatectomy with microwave ablation and had received 2 cycles of chemotherapy with the second treatment on April 3, 2018. Additional chemotherapy treatments were scheduled at 2 week intervals. A seroma was noted following the liver resection but as it was stable, drainage was delayed at the request of the patient. She was admitted to hospital on April 3, 2018 due to a possible chemotherapy related toxicity (shortness of breath, choking sensations, aphonic) most likely associated with oxaliplatin exposure to cold weather conditions. No hives, swelling or syncope were noted. The patient was treated conservatively with hydrocortisone and benadryl and also with clonazepam for anxiety. On April 4th, the patient was noted to be stable, not in any distress with normal vitals and a soft abdomen and no tenderness on palpation. The abdominal fluid collection was noted to pass proximally into the left midclavicular line and almost down to the level of the umbilicus. A chest computed tomography (CT) scan showing the upper extent of the fluid collection suggested the fluid collection was organized and not generalized ascites. The patient expressed concern regarding a Jackson-Pratt surgical drain and having this removed. At this time there was no concern the fluid collection was infected and no gas septations or debris layering. A percutaneous drain was considered.