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Nail pigmentation
Published in Robert Baran, Dimitris Rigopoulos, Chander Grover, Eckart Haneke, Nail Therapies, 2021
Robert Baran, Dimitris Rigopoulos
Non melanocytic pigmentation caused by medications has a different pathogenesis, deposition of pigments in the dermis of the periungual region. Minocycline has been reported to cause nails to appear a blue-gray color, but typically spares the lunula (Geria et al. 2009). A blue, brown, or grey pigmentation that does not move distally with growth can be seen in patients treated with long-term antimalarial therapy (Kalabalikis et al. 2010). Zidovudine causes a characteristic blue or brown hyperpigmentation of the nails, with blue lunulae and/or dark brown nail plates (Piraccini and Tosti 1999). Azure nails are classically described in silver toxicity.
Introduction to Artificial Intelligence and Deep Learning with a Case Study in Analyzing Electronic Health Records for Drug Development
Published in Harry Yang, Binbing Yu, Real-World Evidence in Drug Development and Evaluation, 2021
Azure, on the other hand, has focused on specific use cases and has some advantages over AWS in some fields. For example, it is believed that their support to the .Net Framework and SQL database is beyond what AWS can achieve at this point. In addition, Microsoft successfully leveraged its experience working with enterprise users to make Azure more attractive. The Office ecosystem is unarguably one good reason for companies to choose Azure over AWS. Azure also leads in hybrid cloud service, which is a key factor for companies not willing to upload all their data on the cloud and thus need the bridge between private cloud and public cloud.
Consumer-Grade Cameras and Other Approaches to Surface Imaging
Published in Jeremy D. P. Hoisak, Adam B. Paxton, Benjamin Waghorn, Todd Pawlicki, Surface Guided Radiation Therapy, 2020
While the gaming Kinect product has been discontinued, its capabilities now exist in both the current Microsoft HoloLens3 and a cloud-based version of the camera called Azure Kinect released in 2019 (Figure 25.1). The Azure Kinect camera and software developer kit (SDK) consists of a 12 megapixel color imaging system, 7 audio channels, and a 1 megapixel depth camera. This is a significant improvement over the original Kinect’s depth camera. The system has been designed for development into multicamera arrays or mobile applications. The Azure Kinect includes SDKs and APIs for building artificial intelligence elements such as computer vision and speech models.
Hydrophobic ion pairing with cationic derivatives of α-, ß-, and γ-cyclodextrin as a novel approach for development of a self-nano-emulsifying drug delivery system (SNEDDS) for oral delivery of heparin
Published in Drug Development and Industrial Pharmacy, 2021
Masoomeh Bahiraei, Katayoun Derakhshandeh, Reza Mahjub
To characterize the prepared ion-paired hydrophobic heparin-CPCD complexes, the recovery of the complexes in hydrophobic media were determined using extraction by n-hexane. Briefly, n-hexane (5 ml) was added to each complex, and the mixture was vigorously shaken for 20 min by a vortex mixer. The mixture was then centrifuged at 5000 rpm for 10 min to complete phase separation. Finally, the amount of heparin in the aqueous phase was determined using Azure A colorimetric method previously published in the literature [30]. Azure A is a positively charged dye that forms a purple-colored complex with the negatively charged functional groups of heparin. In brief, 0.5 ml of supernatant containing heparin was reacted with 2 ml of Azure-A solution (100 ng/ml) [30]. For better comparison, the same concentrations of heparin, without adding any CPCDs, were served as the control. Finally, the amount of heparin-CPCD complexes retrieved in the organic phase (i.e. n-hexane) was calculated by subtracting the quantified amount of heparin in the aqueous phase from the total amount of heparin used for the preparation of complexes and the percentage of recovery in the n-hexane was calculated using the Equation (1):
Phenylalanine 4-monooxygenase: the “sulfoxidation polymorphism”
Published in Xenobiotica, 2020
Stephen C. Mitchell, Glyn B. Steventon
Methylene blue was the first xenobiotic cited in the literature as undergoing oxygenation at the sulfur moiety (Underhill & Closson, 1905). The metabolite referred to as methylene azure was presumed to be the sulfone derivative (Williams, 1959), but now the several methylene azures (and thionine) are recognised as a series of sequential N-demethylated products (Disanto & Wagner, 1972). Likewise, the sulfone of mustard gas, presumably formed via the sulfoxide, was postulated in a 1921 publication but was not experimentally confirmed at that time (Flury & Wieland, 1921). However, later work has shown the existence of both these sulfoxide and sulfone metabolites (Davison et al., 1961; Somani & Babu, 1989). The first demonstration of the in vivo formation of a xenobiotic sulfoxide metabolite was that of the anthelmintic, phenothiazine, reported in 1947 (Clare, 1947). This compound itself enjoyed a period of widespread fame as an effective vermifuge but is now known mainly as the parent molecule of a host of clinically useful phenothiazine drugs.
Micellar formulations of Crizotinib and Dasatinib in the management of glioblastoma multiforme
Published in Journal of Drug Targeting, 2018
Khaled Greish, Anfal Jasim, Neha Parayath, Sara Abdelghany, Ali Alkhateeb, Sebastien Taurin, Hayley Nehoff
In order to assess the expression and activity of proteins involved in the survival, proliferation and invasion of GBM, western blotting was undertaken as a semi-quantitative experiment. A total of 200,000 cells/well of multiple GBM cell lines was seeded in 10-cm Petri dishes. After 24-h incubation, cells were treated for 48 h with the drug concentrations mentioned above, washed with PBS, lysed and proteins concentrations were determined and normalised using BCA assay as previously described [16]. Lysates were subjected to SDS–polyacrylamide gel electrophoresis. Proteins were transferred to a polyvinylidene difluoride membrane, blocked with a 2% BSA and incubated with the appropriate antibodies overnight at 4 °C. Horseradish peroxidase-conjugated secondary antibodies were used to visualise with SuperSignal West Pico substrate [Thermo Fisher Scientific Co., Waltham, MA]. The blots were scanned using the Quantity One programme at 600 dpi. The intensity of the resulted bands was determined using Azurespot software version 14.2 (Azure Biosystems, Inc Dublin, CA).