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Advances in Nanonutraceuticals: Indian Scenario
Published in Harishkumar Madhyastha, Durgesh Nandini Chauhan, Nanopharmaceuticals in Regenerative Medicine, 2022
Amthul Azeez, Mubeen Sultana, Lucky, Noorjahan
The Fourier transform infrared (FTIR) spectroscopy and inductively coupled plasma atomic emission spectroscopy (ICP-OES) studies of this nanodrug revealed that the drug is absolutely safe as the heavy metals are below detectable levels. The active compound Rasasm is also within 3 ppm as per admissible limits of medicine. The SEM studies revealed that the drug was within 1–100 nm size. Siddha medicine has a lot of hidden treasures that can be applied in the treatment of different life-threatening diseases (Kanniyan and Muthu 2020). Hence scientific validation and interpretation of herbomineral medicines with knowledge of certain modern nanotechnology will help build the gap between the areas of failure in the medical system.
Release of Nickel Ion from the Metal and Its Alloys as Cause of Nickel Allergy
Published in Jurij J. Hostýnek, Howard I. Maibach, Nickel and the Skin, 2019
Jurij J. Hostýnek, Katherine E. Reagan, Howard I. Maibach
The quality of the data reviewed represents state of the science at the time these studies were performed; subsequent advances in analytical chemistry and physical detection methods applicable to biological materials, such as inductively coupled plasma atomic emission spectroscopy and mass spectroscopy, permit highly reliable analyses of contamination and release concentrations down to the ppm and even to the ppb level for most heavy metals, including nickel. With the graded patch data now available, the ppm level is clinically relevant in terms of NAH elicitation (Andersen et al., 1993). Previous limitations can now be technically dealt with without the need to resort to nucleotides.
Nanocarrier Technologies for Enhancing the Solubility and Dissolution Rate of Api
Published in Debarshi Kar Mahapatra, Sanjay Kumar Bharti, Medicinal Chemistry with Pharmaceutical Product Development, 2019
Ashwini Deshpande, Tulshidas S. Patil
Composition: Surface techniques like secondary ion mass spectrometry and X-ray photoelectron spectroscopy. To analyze bulk samples, commonly they are digested after which wet chemical analyzes like atomic emission spectroscopy, mass spectrometry and ion chromatography are implemented.
In vitro and in vivo characteristics of doxorubicin-loaded cyclodextrine-based polyester modified gadolinium oxide nanoparticles: a versatile targeted theranostic system for tumour chemotherapy and molecular resonance imaging
Published in Journal of Drug Targeting, 2020
Tohid Mortezazadeh, Elham Gholibegloo, Mehdi Khoobi, Nader Riyahi Alam, Soheila Haghgoo, Asghar Mesbahi
FTIR spectra of the prepared samples were obtained through a Fourier transform infrared spectrometer (Magna 550, Nicolet) at the wavelength range of 400–4000 cm−1. The crystal structure of Gd2O3@PCD-FA-DOX NPs was assessed by X-ray powder diffraction system (STOE Theta-Theta Powder Diffraction System). Ultraviolet visible (UV–Vis) spectra were taken using Jasco-530 spectrophotometer at the wavelength range of 220–700 nm. Elemental analysis was determined by inductively coupled atomic emission spectroscopy, ICP-AES (7900, Agilent). Hydrodynamic size distribution and zeta potential analyses were performed by Zeta-sizer (ZEN3600, Malvern) in deionised water at room temperature. Size and morphology of the dried samples were determined by field emission scanning electron microscopy, SEM (MIRAII and MIRAIII Tescan) and transmission electron microscopy, TEM (CM30, Philips) operating at 60 kV. Vibrating sample magnetometer (VSM) measurements were done by VSM, 7400 model (Lakeshore Cryotronics Inc., USA), with a maximum magnetic field of 10 kOe at 25 °C to evaluate the magnetic properties of the samples. Thermogravimetric analysis (TGA) was conducted on the dried powder samples on the TGA Q50 thermogravimetric analyser of a TA instrument from room temperature to 800 °C in a heating rate of 10 °C min−1 under N2 flow. Phantom, in vitro, and in vivo MR imaging were performed by a 3.0 T MRI clinical scanner (Siemens Prisma MRI Scanner using head coil).
Albumin-bioinspired iridium oxide nanoplatform with high photothermal conversion efficiency for synergistic chemo-photothermal of osteosarcoma
Published in Drug Delivery, 2019
Wenguang Gu, Tao Zhang, Junsheng Gao, Yi Wang, Dejian Li, Ziwen Zhao, Bo Jiang, Zhiwei Dong, Hui Liu
The morphology of NPs was observed by JEOL-2100 transmission electron microscopy (TEM, JEOL, Japan). UV-1800 Spectrophotometer was used to record UV-vis absorption spectra with a 1 cm cuvette (Shimadzu, Japan). An IR Prestige-21 spectrometer was used to record the Fourier transform infrared (FTIR) spectrum (Shimadzu, Japan). X-ray photoelectron spectras (XPS) were measured with EscaLab 250Xi electron spectrometer from VG Scientific using 300 W Al Kα radiations (Thermo Fisher Scientific, USA). The hydrodynamic diameters and Zeta potential were conducted on Malvern Zetasizer Nanoseries (Nano ZS90, Malvern, UK). The content of Ir was detected by inductively coupled plasma-atomic emission spectroscopy (ICP-AES, Agilent Technologies). Thermal images were also captured with the TI100 infrared thermal imaging camera (FLK-TI100 9HZ, FLUKE).
A health risk assessment of heavy metals in people consuming Sohan in Qom, Iran
Published in Toxin Reviews, 2018
Mohammad Javad Mohammadi, Ahmad Reza Yari, Mojgan Saghazadeh, Soheil Sobhanardakani, Sahar Geravandi, Abolhasan Afkar, Seyedeh Zahra Salehi, Aliasghr Valipour, Hamed Biglari, Seyed Ahmad Hosseini, Babak Rastegarimehr, Mehdi Vosoughi, Yusef Omidi Khaniabadi
This cross-sectional study was carried out in 2015 to investigate the health risk assessment of Heavy Metals for the population who consume Qom’s Sohan in Qom, Iran. In the current study, two types of butter and vegetable oil Sohan among all Sohan workshops in Qom, that is 100 samples (50 butteries and 50 vegetables oil), were randomly selected and 250 g of both types were taken as samples; samples were placed into Sohan storage containers and sent to the laboratory. In the laboratory, samples were homogenized; then they were crushed in a mortar. Extraction of metals was done by dry the digestion method. For this purpose, 1 g of each sample placed into a high form porcelain crucible. The furnace temperature slowly increased from room temperature to 450 °C in 1 h. Samples were ashed for about 16 h until a white or gray ash residue was obtained. The residue was dissolved in 5 ml of HNO3 (25% v/v) and the mixture, where necessary, was heated slowly to dissolve the residue. The solution was transferred to 10 ml volumetric flask and made up to volume. A blank digest was carried out in the same way. All elements were determined against aqueous standards, using inductively coupled plasma atomic emission spectroscopy (ICP-AES) (Model: Varian, 710-ES, Germany) (Duran et al. 2009). All instrumental conditions applied for As, Cd, Cu, Pb, Ni, Sn, and Zn content determinations were set in accordance with general recommendations (wave length for As, Cd, Cu, Ni, Pb, Sn, and Zn: 188.98 nm, 226.5 nm, 324.75 nm, 231.6 nm, 220.35 nm, 224.6 nm, and 206.2 nm, respectively).