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Unbiased research
Published in C. P. Khare, Evidence-based Ayurveda, 2019
The study revealed for the first time a possible anorectic activity of Benincasa hispida, most probably mediated through the CNS without affecting the gastric emptying. However, further studies are required to find its potential as an antiobesity agent.
Regulation of Food Intake
Published in Nathalie Bergeron, Patty W. Siri-Tarino, George A. Bray, Ronald M. Krauss, Nutrition and Cardiometabolic Health, 2017
Surya Panicker Rajeev, Ian W. Seetho, John P.H. Wilding, Nathalie Bergeron, Patty W. Siri-Tarino, George A. Bray, Ronald M. Krauss
CCK infusion (the C-terminal octapeptide of CCK) decreased food intake in lean individuals [63] suggesting its possible role as an appetite suppressant. The OLETF (Otsuka Long-Evans Tokushima Fatty rat) lacking the CCK1 receptor was demonstrated to be obese and diabetic with defective control of meal sizes, and CCK receptor deficiency was thought to be the reason for obesity in these rodents (along with NPY overexpression) [64]. This suggested that CCK might have a physiological role in meal intake. However, chronic administration of CCK (2 weeks of intraperitoneal infusion) in rodent models was not associated with any changes in body weight or food consumption [65], and trials of CCK agonists in humans have not proceeded beyond phase 2 due to adverse effects. Thus, the therapeutic potential of CCK as an antiobesity agent may be limited.
Pharmacotherapy
Published in G. Michael Steelman, Eric C. Westman, Obesity, 2016
Clinical effectiveness —Phentermine is still the most effective antiobesity agent. A recent study of long-term phentermine use found that 83% of patients had weight loss equal to or greater than 10 of initial baseline weight at 1 year (26).
Effectively suppressed angiogenesis-mediated retinoblastoma growth using celastrol nanomicelles
Published in Drug Delivery, 2020
Zhanrong Li, Zhihua Guo, Dandan Chu, Huayang Feng, Junjie Zhang, Lei Zhu, Jingguo Li
Our previous study showed that celastrol nanomicelles (CNMs) inhibited the growth of retinoblastoma in mouse xenograft model through inducing the apoptosis of human retinoblastoma SO-Rb 50 cells (Li et al., 2012). We also found that CNMs suppressed effectively the corneal neovascularization (Li et al., 2012; Li et al., 2016). Whether celastrol could modulate retinoblastoma angiogenesis has not been validated yet. Celastrol, a pentacyclic triterpene extracted from Thunder of God Vine, is a potent anti-inflammatory, anti-angiogenesis, anticancer and antiobesity agent (Feng et al., 2019). Nevertheless, the further clinical application of celastrol is restricted by its poor water solubility. In the previous study, we developed celastrol-loaded nanomicelles which could significantly improve the apparent solubility of celastrol (Li et al., 2012). Therefore, in this study, we investigated the effect of CNMs on retinoblastoma angiogenesis.