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Triamcinolone
Published in Anton C. de Groot, Monographs in Contact Allergy, 2021
General aspects of corticosteroids used on the skin and mucous membranes are discussed in Chapter 2.4. A practical guideline for diagnosing allergic reactions to corticosteroids is presented in ref. 1. Triamcinolone base (alcohol) is used in tablets only. In other applications, esters are used: triamcinolone acetonide (Chapter 3.353), triamcinolone diacetate (Chapter 3.354) or triamcinolone hexacetonide (Chapter 3.355). In topical preparations, triamcinolone acetonide is (virtually) always used. As triamcinolone base is used in oral preparations only, most positive patch test reactions to this corticosteroid must have been the result of sensitization to one of its esters or of cross-sensitization to another corticosteroid.
Biotransformation of Sesquiterpenoids, Ionones, Damascones, Adamantanes, and Aromatic Compounds by Green Algae, Fungi, and Mammals
Published in K. Hüsnü Can Başer, Gerhard Buchbauer, Handbook of Essential Oils, 2020
Yoshinori Asakawa, Yoshiaki Noma
The possible biogenetic pathways of (+)-cuparene (324) have been proposed in Figure 23.97. Unfortunately, none of the metabolites show strong mossy odor (Hashimoto et al., 2006). The presence of an acetonide in the metabolites has also been seen in those of dehydronootkatone (25) (Furusawa et al., 2003) (Figure 23.98).
Psoriasis
Published in Nilton Di Chiacchio, Antonella Tosti, Therapies for Nail Disorders, 2020
Stamatis Gregoriou, Eftychia Platsidaki, Dimitris Rigopoulos
When the nail bed is affected, injections must be performed at the lateral nail folds in the nail bed.2 Side effects include skin atrophy, depigmentation, cyst formation, tendon rupture, and subungual hemorrhage.3 Iontoforesis with triamcinolone acetonide once per month might be a good alternative to reduce adverse events.4 Several studies consider 8% clobetasol nail lacquer used twice a week for 16 weeks as an effective and safe treatment for both nail matrix and nail bed signs of psoriasis.5–7
Transdermal delivery via medical device technologies
Published in Expert Opinion on Drug Delivery, 2022
Shubhangi Shukla, Ryan H. Huston, Blake D. Cox, Abhay R. Satoskar, Roger J. Narayan
Researchers have chosen to avoid the water solubility issue by using other nontoxic organic solvents for their iontophoresis buffer mixture. One study dissolved triamcinolone acetonide in a solution of N-N,-dimethylacetamide (as the organic solvent) and water at a ratio of 7/3 v/v [129]. Triamcinolone acetonide is an uncharged drug that is used to inhibit collagen synthesis for keloid and hypertrophic scar treatment. This drug was typically administered via pressure jet injection; however, this approach caused discomfort to patients, necessitating the development of alternative delivery methods [129]. Rats that were treated with iontophoresis for 30 minutes were found to retain triamcinolone acetonide in their skin 24 hours after treatment, indicating the success of N-N,-dimethylacetamide as an alternative solvent for drugs that may not otherwise be suitable for delivery using iontophoresis [129].
Efficacy and Safety of Corticosteroid Implants in Non-infectious Uveitis: A Systematic Review with Network Meta-analysis
Published in Ocular Immunology and Inflammation, 2022
Rafael Vieira, Bernardo Sousa-Pinto, Luís Figueira
We obtained 8218 search results, of which 8 different studies (assessing a total of 1621 participants) met the inclusion criteria and were included in this systematic review (Supplementary File 2).13–15,22-26 Study characteristics are summarized in Table 1. Two trials compared fluocinolone acetonide 0.59 mg versus 2.1 mg (results of the meta-analyses involving these two studies are available in Supplementary File 3).23,24 Two studies compared the 0.59 mg fluocinolone acetonide implants with systemic therapy.22,25 Another study compared the 0.70 mg dexamethasone implant with injections of triamcinolone acetonide.26 The other three trials compared sham procedures with (i) dexamethasone implants (0.70 mg and 0.35 mg) (1 study),14 or (ii) 0.18 mg fluocinolone acetonide implants (2 studies).13,15 Two of the latter three studies (assessing a total 358 patients) were included in network meta-analyses.13,14 The risk of bias summary is available in Supplementary File 4. Results of the quality assessment of primary studies and of the application of CINeMA tool are depicted in Figure 1.
Comparison of therapeutic effects of steroid injection by benign vocal fold lesion type
Published in Acta Oto-Laryngologica, 2021
Satoka Takahashi, Takeharu Kanazawa, Tomohiro Hasegawa, Mayu Hirosaki, Daigo Komazawa, Ujimoto Konomi, Yoshitsugu Nimura, Yu Sakaguchi, Miki Nozawa, Tomohiko Yamauchi, Yusuke Watanabe
We used a commercial form of triamcinolone acetonide with a depot solution to prolong the development period (KENACORT-A; Bristol-Myers Squibb K. K., Tokyo, Japan). The KENACORT-A was injected under local anesthesia. In brief, the pharynx and larynx were completely anaesthetized with 4% lidocaine. Three milligrams of triamcinolone acetonide dissolved in 0.3 ml per side of depot solution was injected into and spread onto the superficial lamina propria (SLP), and not into the muscle layer, using a 23-gauge injection needle (Varixer; TOP Corp., Tokyo Japan) under transnasal fiberscopic monitoring of the larynx (Figure 1). The triamcinolone acetonide dose was determined by referring to the manufacturer’s instructions and a previous study [11]. All the participants received the injection bilaterally. To detect possible allergic reactions such as vocal fold edema, the vocal folds were checked using a fiberscope one hour after the injection. Participants received a single dose of injection, which was not repeated. Participants were instructed to rest their voices on the day of the injection but were allowed to use their voices from the following day onwards according to our previously reported injection protocol [12].