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Catalog of Herbs
Published in James A. Duke, Handbook of Medicinal Herbs, 2018
Contains 3 to 5% essential oil with 20% ( + )-sabinene and 40% ( + )-sabinylacetate, and traces of ( + )-alpha-pinene, myrcene, ( + )-limonene, γ-terpiene, p-cymol, ( + )-iso-thujone, ( + )-terpineol-(4), ( + )-sabinol, ( + )-citronellol, ( + )-cadinene, and ( - )-elemol, even lower levels of α-thujene, camphene, α-terpinen, 1-8-cineole, terpinolene, thujone, geraniol, δ-cadinol, carvacrol, perillalcohol, caprinaldehyde, and diacetyl; Russian samples show betapinene, Δ 3-carene, sabinylacetate, and cedrol. Tannin, wax with sabine-acid, jumperinacid, and thaspia acid, sugar, calcium salts, pinipicrin, gallic acid, sabinene (C20H16O6), and podophyllotoxin.13
The use of terpenes and derivatives as a new perspective for cardiovascular disease treatment: a patent review (2008–2018)
Published in Expert Opinion on Therapeutic Patents, 2019
Eric Aian P. Silva, Jéssica S. Carvalho, Adriana G. Guimarães, Rosana de S.S. Barreto, Márcio R.V. Santos, André S. Barreto, Lucindo J. Quintans-Júnior
In relation to treatment of metabolic disorders, such as hyperglycemia and hyperlipidemia, were found four patents in that area. In 2009, Jeong et al. [30], from South Korea, patented an extract for prevention and treatment of cardiovascular disease from Torreya nucifera which has a novel abietane diterpenoid namely 12-hydroxyabietic-8,11,13-trien-18-dimethylacetyl (2). The extract has also other terpenes, such as isopimaric acid, dehydroabietinol, kayadiol, and δ-cadinol. The compounds was tested in infusion and the methanolic phase. The results showed great antioxidative activity to low-density lipoprotein (LDL) by TBARS method and also significantly inhibited Acyl-CoA and cholesterol acyltransferase (ACAT), thus reducing blood LDL cholesterol and total cholesterol. Thus, this compound may provide a novel drug for the prevention and treatment of cardiovascular diseases such as hyperlipidemia and atherosclerosis, which can be caused by oxidation of LDL. Additionally, a toxicity test in mice was performed, which they were treated orally once (100, 500, and 1,000 mg/kg, p.o) and no toxicity was detected neither from weight changes, hematological and biochemical tests nor autopsy.