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Published in Anton Sebastian, A Dictionary of the History of Medicine, 2018
Schiller Test Test for carcinoma, where the cervix is painted with Gram stain to detect unstainable areas of possible carcinoma. Devised by Austrian pathologist, Walter Schiller (1887–1960) of Vienna. After working in various parts of Europe and the Middle East, he joined the Jewish Memorial Hospital in NewYork in 1937 and later worked at the Cook County Hospital, Chicago from 1938 to 1944.
Can we predict surgical margin positivity while performing cervical excisional procedures?
Published in Journal of Obstetrics and Gynaecology, 2020
Yasin Durmuş, Alper Karalök, Derman Başaran, Mustafa Onur Kamani, Nurettin Boran, Sevgi Koç, Ahmet Taner Turan
The Schiller test was performed to determine excision field limits before CEP, and ECC was performed to evaluate the remaining endocervix following cone specimen removal. Conisation specimens were marked with a suture at 12 o’clock before being sent for pathological examination. Conisation specimens were divided into four quadrants by two axes (horizontal and vertical), and involvement of each quadrant was reported separately. The cone base major and minor axes, as well as depths (or heights) of the specimens were obtained from the gross descriptions in the pathology reports. Specimen base areas were calculated using the Ellipse Area Formula: Area = Semi-major axis × Semi-minor axis × π. For NETZ and CKC specimens, the volume of the specimen was calculated using the Elliptic Cone Volume Formula: Volume = Semi-major axis × Semi-minor axis × Height (Depth) × π/3. For LEEP specimens, the volume of the specimen was calculated using the Semi-Ellipsoid Volume Formula: Volume = Semi-major axis × Semi-minor axis × Bisected Axis (Depth) × 2π/3. All measurements were obtained from pathology reports after formaldehyde fixation.
Local ultra-low-dose estriol gel treatment of vulvo-vaginal atrophy: efficacy and safety of long-term treatment
Published in Gynecological Endocrinology, 2020
Paola Villa, Valeria Tagliaferri, Inbal Dona Amar, Clelia Cipolla, Fabio Ingravalle, Giovanni Scambia, Walter Ricciardi, Antonio Lanzone
Regarding the objective evaluation, a significant improvement of the Schiller’s test (p<.05), flattening of folds (p<.01), and PH reduction after 30 weeks of treatment compared with baseline (p<.01) were documented. Comparing the first and second treatment cycles, further clinical improvements emerged: vaginal folds increase, petechiae, and PH significant decrease (p<.01). The TO-Score resulted significantly higher comparing baseline and first cycle (p<.01). At the end of the long-term treatment, none of the patients had severe VVA; 33% had mild and 3.7% moderate VVA; 63% showed a completely resolved condition.