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Rheumatology
Published in Kristen Davies, Shadaba Ahmed, Core Conditions for Medical and Surgical Finals, 2020
Reactive arthritis is an arthritis that occurs following an infection where the organism cannot be recovered from the joint. It classically occurs following either an STI or gastroenteritis but can occur following any infection. Reactive arthritis following STI acquisition is more common in men (10:1).
Chlamydia trachomatis
Published in Firza Alexander Gronthoud, Practical Clinical Microbiology and Infectious Diseases, 2020
Genital Chlamydia infection is known to cause reactive arthritis in 1% of patients. Usually, reactive arthritis will settle after treatment of the primary cause, but incidentally, short-lived anti-inflammatory therapy is needed.
Unexplained Fever Associated with Musculoskeletal Disorders
Published in Benedict Isaac, Serge Kernbaum, Michael Burke, Unexplained Fever, 2019
Moreover, the spectrum of the various reactive arthritis is not distant from Reiter’s syndrome,59 whose diagnosis relies on the association of a predominantly axial severe polyarthritis with purulent conjunctivitis and either nongonococcal urethritis or bacterial diarrhea (due to Shigella, Salmonella, Campylobacter, or Yersinia). It does not present as U.F. because the classic triad is necessary to support the diagnosis.59 But one may assume that it could be a cause of undiagnosed fever when the triad is not documented, and one of the various extraarticular lesions is associated with reactive arthritis: cutaneous (keratoderma, blennorrhagia, erythema nodosum), mucosal (oral ulcers, circinate balanitis) ocular (iritis, conjunctivitis), neurologic lesions, myositis, nephritis, carditis ... 59 The diagnosis of reactive arthritis relies on The sterile joint fluidThe frequent but inconstant presence of HLA-B 27 antigenThe demonstration by serodiagnosis (Yersinia . . . ) and/or by isolation in the other body fluids (blood, stools, infectious focus . . . ) of the causal agentThe demonstration of the infectious focus, whose cure leads to apyrexia and resolution of arthritis
The increased risk of atrial fibrillation in inflammatory arthritis: a systematic review and meta-analysis of cohort studies
Published in Immunological Investigations, 2022
Yubo Ma, Zhipeng Pan, Dazhi Fan, Shanshan Xu, Faming Pan
Two reviewers (Yubo Ma and Zhipeng Pan) independently searched PubMed, Web of Science, and Cochrane Library for cohort studies evaluating the relationship between AF and inflammatory arthritis from inception to August 1, 2019. The key words of this study were AF and inflammatory arthritis including RA, AS, PsA, reactive arthritis, and SpA. The detailed search strategies were documented in Supplementary Figure S1. We also manually searched the bibliographies of relevant reviews and included studies to identify the research that might be missed during database retrieve. When necessary, we contacted the corresponding authors to obtain full-text or relevant data. To identify the potential grey literatures, we also searched Clinical Trials Registry (http://www.ClinicalTrials.gov) and China National Knowledge Infrastructure (http://www.cnki.net), the most commonly used Chinese database, from inception to August 1, 2019.
Bilateral sacroiliitis following group C streptococcal sepsis
Published in Baylor University Medical Center Proceedings, 2022
Sanjeev Shrestha, Eva Rottmann, Prakash Kharel, Francis Lim, David Henry Bulbin
Reactive arthritis is an inflammatory aseptic arthritis, usually developing 1 to 4 weeks after an antecedent extraarticular infection.1 It is a subgroup of related but phenotypically distinct disorders called the spondyloarthropathies, but accounts for <2% of disease burden within the group.2,3 It affects both men and women, particularly those in the age group of 20 to 40 years.4,5 The most common preceding infections include enteric infections (Salmonella, Shigella, Yersinia, Campylobacter, Clostridioides difficile, Escherichia coli) and urogenital infections (Chlamydia trachomatis, Ureaplasma urealyticum, Mycoplasma genitalium).3,4 The association of group C and group G streptococcal infection with reactive arthritis has been sporadically reported, with four cases described in a 1998 case series.6 We report a case of elderly-onset bilateral sacroiliitis following group C streptococcal sepsis.
Anti-CD6 mAbs for the treatment of psoriasis
Published in Expert Opinion on Biological Therapy, 2020
Sunil Dogra, Shabeer D, Murlidhar Rajagopalan
Patients with psoriasis also suffer from several comorbities, one of which is PsA that affects about 20–30% of them impacting patient’s quality of life. The efficacy and safety of Itolizumab in PsA has been demonstrated in few studies and case reports [10,48,56,57]. Sjogren’s syndrome is a condition which affects the salivary glands [44], expression of ALCAM on salivary epithelial cells reflect there could be a role of Itolizumab in its treatment. ALCAM is also expressed in the synovium and endothelium of blood brain barrier and a possible role in RA and multiple sclerosis respectively, is also being studies [58,59]. T cell subpopulations, and plasma levels of proinflammatory cytokines studied to support the relevance of the CD6 molecule as a therapeutic target for the treatment of RA [19]. An initial study to assess Itolizumab’s therapeutic function in B-cell chronic lymphocytic leukemia and cutaneous T-cell lymphoma shows promising results; however, larger samples are needed to ascertain the positive response [49]. It has also been tried in reactive arthritis with fast response but relapse of discontinuation [60].