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Antiseptics, antibiotics and chemotherapy
Published in Michael J. O’Dowd, The History of Medications for Women, 2020
Griseofulvin was discovered by Raistrick and his colleagues in 1939 in an isolate of Penicillium griseofulvum. Griseofulvin was first used to treat fungal disease in plants and it was not until 1958 that it was employed in the treatment of animal and human mycoses.
History of antifungals
Published in Mahmoud A. Ghannoum, John R. Perfect, Antifungal Therapy, 2019
Emily L. Larkin, Ali Abdul Lattif Ali, Kim Swindell
Griseofulvin, a compound derived from Penicillium griseofulvum, has been widely used to treat superficial fungal infections since its isolation in 1939 [15]. In 1958, Gentles [16] reported the successful treatment of ringworm in guinea pigs using oral griseofulvin.
Antifungals
Published in Sarah H. Wakelin, Howard I. Maibach, Clive B. Archer, Handbook of Systemic Drug Treatment in Dermatology, 2015
Marie-Louise Daly, Victoria J. Hogarth, Hui Min Liew, Mary Sommerlad, Rachael Morris-Jones
Griseofulvin was first obtained from the mould Penicillium griseofulvum in 1939 and has been used as an oral therapy for superficial fungal infection since the 1960s. It has fungistatic actions and is most effective against dermatophytes that cause tinea (ringworm) infections. It is deposited in newly formed keratin in the skin and hair and is thought to confer resistance against fungal infection by inhibiting the formation of fungal microtubules. Griseofulvin may also have anti-inflammatory and immunomodulatory effects.
Bacteria and fungi as major bio-sources to fabricate silver nanoparticles with antibacterial activities
Published in Expert Review of Anti-infective Therapy, 2022
Also, there are several fungi and bacteria sources having natural antibiotics metabolites. In the case of fungi, griseofulvin and cephalosporin antibiotics produced by the mycelium of Penicillium griseofulvum and Acremonium chrysogenum, respectively [20]. In the case of bacteria, Streptomyces hygroscopicus, Saccharopolyspora erythraea related to Actinomycete, Streptomyces griseus, Streptomyces aureofaciens, and Amycolatopsis orientalis are used to produce geldanamycin, erythromycin, streptomycin, tetracycline, and vancomycin antibiotics, respectively [21,22]. It is worth noting that the phylum Actinobacteria specifically the genus Streptomyces can produce ~80% of the most antibiotics [23]. Physicochemical properties and chemical structures of important secondary metabolites extracted from bacteria and fungi are presented in Table 1, respectively.
Mycotoxin patulin in food matrices: occurrence and its biological degradation strategies
Published in Drug Metabolism Reviews, 2019
Marina Sajid, Sajid Mehmood, Yahong Yuan, Tianli Yue
Patulin (4-hydroxy-4H-furo[3,2-c]pyran-2(6H)-one) is a water-soluble polyketide lactone. It was first time isolated in the 1940s from Penicillium griseofulvum and Penicillium expansum as a part of the screening efforts to find new fungal molecules with antibiotic properties, in the general enthusiasm following the discovery of penicillin by Fleming (Birkinshaw et al. 1943; Stott and Bullerman 1975; Puel et al. 2010). Patulin fits well with Paracelsus’s definition in his treatise ‘Von der besucht’. ‘Every substance is a poison; the only dose distinguishes a poison from drug’. This compound was tested in clinical trials by a British company under the brand name ‘tercinin’ (Chalmers and Clarke 2004; Puel et al. 2010); however, it was banned due to its toxicity to humans and animals.