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Cognitive Improvement, Neuroprotective, and Nootropic Effect of Medhya Rasa¯yana Drugs in Alzheimer’s Disease
Published in Atanu Bhattacharjee, Akula Ramakrishna, Magisetty Obulesu, Phytomedicine and Alzheimer’s Disease, 2020
Rinki Kumari, Jasmit Singh, Bhargawi Mishra, Anamika Tiwari, Abaidya Nath Singh
Śankhapuṣpī composite, containing Śankhapuṣpī, Sarpagandhā, and Gokṣura in equal quantities, has been shown to be effective in treating Cittodvega (anxiety disorders). Sanjay Parsania reported Śankhapuṣpī to be effective at relieving signs and symptoms of Cittodvega. Herbalists believe that Śankhapuṣpī calms the nerves by regulating the body’s production of the stress hormones, adrenaline and cortisol. Several investigations have reported that Śankhapuṣpī has potent depressive action in mice. C. pluricaulis whole plant extract shows the highest inhibitory activity against Helicobacter muridarum. Its effectiveness in treating Cittodvega (anxiety disorders) reverses the social isolation stress-induced prolongation of onset and decrease in pentobarbitone-induced sleep, increased total motor activity and stress-induced antinociception in an experimental model (Hetal et al., 2014).
Helicobacter hepaticus is required for immune targeting of bacterial heat shock protein 60 and fatal colitis in mice
Published in Gut Microbes, 2021
Verena Friedrich, Ignasi Forné, Dana Matzek, Diana Ring, Bastian Popper, Lara Jochum, Stefanie Spriewald, Tobias Straub, Axel Imhof, Anne Krug, Bärbel Stecher, Thomas Brocker
Only recently, it was reported that especially members of Proteobacteria are able to induce T cell-dependent serum IgA responses in conventionally housed mice to protect them from lethal sepsis.49 In this study, commensal Helicobacter muridarum was identified as the driving species, which would induce mucosal IgA-secreting plasma cells as well as IgA+ bone marrow plasma cells.49 Our data suggest that dysbiosis in DC-LMP1/CD40 mice affects the dissemination of bacteria, inducing systemic IgG as well as IgA production. This hypothesis is also supported by human studies, reporting elevated serum antibody levels in IBD patients.50,51 However, we also found certain levels of bacteria-specific serum IgG in control littermates. One explanation for this observation might be that we used conventionally but not SPF-housed mice for a part of our study. This seems more analogous to healthy humans, where also some level of systemic bacteria-specific IgG exists, which does increase further during IBD.48