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Bacterial, Mycobacterial, and Spirochetal (Nonvenereal) Infections
Published in Ayşe Serap Karadağ, Lawrence Charles Parish, Jordan V. Wang, Roxburgh's Common Skin Diseases, 2022
Laboratory studies: Diagnosis is usually based on the clinical presentation, and bacterial cultures are useful to identify the organism and antibiotic sensitivities; however, cultures are not always necessary. In recurrent or severe skin infections, such as carbuncles, investigations to rule out an underlying contributory factor, such as diabetes mellitus, is necessary.
Inflammatory, Hypersensitivity and Immune Lung Diseases, including Parasitic Diseases.
Published in Fred W Wright, Radiology of the Chest and Related Conditions, 2022
The disease usually starts with a blister at the site of the flea-bite; this may then become a 'black carbuncle'. Fresh carbuncles and spots may appear. Nodal disease then follows in the axillae or groins ('bubonicplague'), later becoming septicaemic with pneumonia (and occasionally also leading to plague meningitis). When pneumonia occurs, with bacilli in the sputum ('pneumonic plague') air-borne transmission may occur from man to man.
Skin infections
Published in Rashmi Sarkar, Anupam Das, Sumit Sethi, Concise Dermatology, 2021
Shankila Mittal, Rashmi Sarkar
A carbuncle is an infection of contiguous hair follicles presenting as painful red swelling with pus discharging from multiple follicular orifices (Figure 3.15). Patients with impaired blood sugar are particularly at risk.
A systematic review on efficacy, safety, and treatment-durability of low-dose rituximab for the treatment of Pemphigus: special focus on COVID-19 pandemic concerns
Published in Immunopharmacology and Immunotoxicology, 2021
Soheil Tavakolpour, Zeinab Aryanian, Farnoosh Seirafianpour, Milad Dodangeh, Ifa Etesami, Maryam Daneshpazhooh, Kamran Balighi, Hamidreza Mahmoudi, Azadeh Goodarzi
In the study that three weekly consecutive doses of 375 mg/m2 of RTX and one similar dose repeated after 3 months of the third dose was used [24], the most of Side effects occurred during the first infusions; moderate fever and chills (6/24), hypotension (2/24), and hypertension (2/24) which were controlled by either stopping or decreasing the rate of infusion, was seen. In second infusions, patients experienced no infusion reactions. 8% of patients (2/24) developed herpes zoster and the next infusion was deferred till the lesions healed after treatment with an antiviral drug. One of them also developed an extensive tinea corporis. And, a diabetic patient developed a carbuncle that was treated with antibiotics, after that he involved to pulmonary embolism (a month following the first three infusions) and was treated successfully in an ICU setting. One patient developed recurrent diarrhea with weight loss of 10 kg within a month and was diagnosed with Isospora diarrhea that was treated successfully with cotrimoxazole.
Current advances of Dendrobium officinale polysaccharides in dermatology: a literature review
Published in Pharmaceutical Biology, 2020
Linghong Guo, Jinxin Qi, Dan Du, Yin Liu, Xian Jiang
It has been found that Dendrobium officinale polysaccharides have significant inhibitory effects on Staphylococcus aureus, Bacillus subtilis, Candida albicans, Escherichia coli and Pneumococcus (Zhang et al. 2012; Wang et al. 2016; Zhou et al. 2017). Among them, Staphylococcus aureus is the most common Gram-positive pathogen in dermatology (Wei et al. 2016). Common infectious skin diseases caused by Staphylococcus aureus include pustules, folliculitis, scabies, carbuncles, and staphylococcal scald skin syndrome (Wei et al. 2016). In addition, Candida albicans infection can cause dermatitis (Liu et al. 2014). Therefore, the antibacterial effect of DOP provides a basis for the research and development of natural antibacterial drugs. Subsequent studies should further validate its antimicrobial effects in skin disease models.
Ultrastructural changes induced by Solanum incanum aqueous extract on HCT 116 colon cancer cells
Published in Ultrastructural Pathology, 2018
Ahmed Al-Emam, Mubarak Al-Shraim, Refaat Eid, Mohamed Alfaifi, Mohamed Al-Shehri, Mahmoud Fawzy Moustafa, Khaled Radad
SI is a perennial wild shrub like herb belonging to Solanaceae family. It is native to Sub-Saharan Africa, Middle East, and Far East Asia. The plant grows up to 1.8 meter in height and shows spines on the stems, stalks, and calyces, and with velvet hairs on the leaves. The fruit are small berries of 2–3 cm in diameter and yellowish orange or brown in color when ripen.1 In Africa, SI is used as a folk remedy for various ailments including sore-throat, stomach-ache, colic, headache and wound healing, and pain associated with menstruation, liver problems, pleurisy, pneumonia, and rheumatism. In addition, parts of the plant are used to relieve skin problems such as infections, ringworm, burns, rashes, ulcers, carbuncles, warts, and benign tumors.2,3 Recently, research interest in SI has increased due to finding that the plant has novel active chemical ingredients, with a wide range of pharmacological effects.1 In this context, the steroidal glycoalkaloid solamargine from SI was reported to inhibit proliferation of hepatocellular carcinoma cell lines (SMMC7721 and HepG2) as evaluated by MTT and colony formation assays. This effect of solamargine was attributed to down-regulation of the levels of proliferation-associated (Ki-67 and pcna) and anti-apoptotic (Bcl-2) proteins, and promoting the activity of apoptosis-associated proteins: Bax, caspase-3, and caspase.-9.4