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Prostate Cancer
Published in Karl H. Pang, Nadir I. Osman, James W.F. Catto, Christopher R. Chapple, Basic Urological Sciences, 2021
Karl H. Pang, James W.F. Catto
Atypical small acinar proliferation (ASAP)31–40% risk of PCa on repeat prostate biopsy.A focus of small acinar structures formed by atypical epithelial cells.Does not appear to raise PSA.
Basic Science and Molecular Oncology
Published in Manit Arya, Taimur T. Shah, Jas S. Kalsi, Herman S. Fernando, Iqbal S. Shergill, Asif Muneer, Hashim U. Ahmed, MCQs for the FRCS(Urol) and Postgraduate Urology Examinations, 2020
Paul Cleaveland, Vijay Sangar, Noel Clarke
Which of the following is a neoplastic condition in which malignant cells have not invaded across the cellular basement membrane?MetaplasiaAdenocarcinomaAtypical small acinar proliferationCarcinoma in situPerineural invasion
Prostate cancer
Published in Pat Price, Karol Sikora, Treatment of Cancer, 2014
Prostatic intra-epithelial neoplasia (PIN) was so named because it was presumed to be the precursor of prostate cancer, in the same way that cervical intraepithelial neoplasia (CIN) is of cervical cancer. It was graded according to the degree of cellular atypia, but is generally referred to simply as low-grade PIN or high-grade PIN.30,31 However, its relationship to invasive prostate cancer is much less clear than is the case with CIN and cervical cancer. Any relationship that exists is likely to be predominantly in high-grade and not in low-grade PIN.32 On the other hand, it is equally clear that not all men with high-grade PIN will go on to develop invasive prostate cancer,32–34 and it may be that it is a marker of common risk factors rather than a true biological precursor per se. A second condition, termed atypical small acinar proliferation, is also recognized, and is said to be more likely to progress to frank carcinoma than is high-grade PIN,32,33 although whether some of these are, in fact, low-grade cancers from the outset is conjectural.
Can a prostate biopsy be safely deferred on PI-RADS 1,2 or 3 lesions seen on pre-biopsy mp-MRI?
Published in Arab Journal of Urology, 2023
Rickaz Abdul Raheem, Ahsen Razzaq, Victoria Beraud, Richard Menzies-Wilson, Rakan Odeh, Imoh Ibiok, Prashant Mulawkar, Henry Andrews, Iqbal Anjum, Khaled Hosny, Tom Leslie
Histopathological diagnoses of these biopsies were evaluated in detail. First, a benign vs a cancer diagnosis was established. Two-thirds of biopsied specimens (141 of 190) showed benign pathology. Benign diagnoses included prostatic hyperplasia, inflammation, high-grade PIN, and atypical small acinar proliferation (Table 2). All the clinically insignificant and significant cancers were studied in detail including Gleason score, percentage of cancer, the maximum cancer core length, site of cancer and the number of positive cores from the total cores. It has been noted that higher volume disease has been noted with clinically significant disease compared to clinically insignificant (Table 3).
Biopsy core length in white versus African descendant prostate cancer patients
Published in Scandinavian Journal of Urology, 2020
Wilmar Azal Neto, Guilherme Miranda Andrade, Athanase Billis, Leonardo O. Reis
All analyses were performed by a single expert uro-pathologist, who classified them according to the International Society of Urological Pathology (ISUP) [15]. High-grade prostatic intraepithelial neoplasm (NIP) and atypical small acinar proliferation (ASAP) were classified as negative for cancer, since their clinical impacts are limited [16].
Natural history of widespread high grade prostatic intraepithelial neoplasia and atypical small acinar proliferation: should we rebiopsy them all?
Published in Scandinavian Journal of Urology, 2021
Marco Oderda, Matteo Rosazza, Marco Agnello, Maurizio Barale, Giorgio Calleris, Lorenzo Daniele, Luisa Delsedime, Marco Falcone, Riccardo Faletti, Claudia Filippini, Andrea Giordano, Alessandro Marquis, Giancarlo Marra, Donatella Pacchioni, Paolo Gontero
High-grade prostatic intraepithelial neoplasia (HGPIN) and atypical small acinar proliferation (ASAP) are common histological findings on prostate biopsy, considered as predictors of prostate cancer (PCa). In the last years, however, the premalignant potential of these lesions has been deeply questioned.