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The gastrointestinal system
Published in C. Simon Herrington, Muir's Textbook of Pathology, 2020
Sharon J. White, Francis A. Carey
The most frequent developmental odontogenic cyst is the dentigerous cyst, which develops around the crown of an unerupted tooth. Closely related is the eruption cyst, which presents as a bluish fluctuant swelling in the gum overlying the crown of an erupting tooth. Both cysts are lined by non-keratinized stratified squamous epithelium, which may include a few mucus-secreting cells. These cysts are usually symptomless unless infected and can grow to several centimetres with considerable bone destruction. They must be differentiated from the odontogenic keratocyst which has a distinctive parakeratinized, stratified squamous epithelial lining (Figure 10.4). Its relationship to the teeth is variable and it occurs anywhere in the jaws, the most common site being the posterior mandible, often extending up into the ramus of the mandible. Although previously categorized as a benign, potentially aggressive odontogenic tumour, odontogenic keratocyst has recently been reclassified as a developmental odontogenic cyst which possesses a high recurrence rate partly due to the friable nature of the lining and the presence of small daughter cysts within the cyst wall. Multiple, recurrent, odontogenic keratocysts are seen as part of the naevoid basal cell carcinoma syndrome (Gorlin syndrome). Mutations in the PTCH1 gene are associated with syndromic and non-syndromic odontogenic keratocysts.
The Classification of Odontogenic Cysts
Published in Roger M. Browne, Investigative Pathology of the Odontogenic Cysts, 2019
An eruption cyst forms in the mucosal soft tissues (Figure 11) overlying the crown of an erupting tooth. As intact histological specimens of the cyst and its associated tooth are only occasionally available for examination, the exact relationship between the crown of the unerupted tooth and the cyst lining is uncertain, but it is widely believed to be the same as that in a dentigerous cyst. It occurs most frequently in the first and second decades, but occasionally arises in patients of greater age. The cyst is generally believed to be developmental in origin arising in association with some interruption in the eruptive pathway of the tooth, but during the soft tissue phase.
Cysts and Tumours of the Bony Facial Skeleton
Published in John C Watkinson, Raymond W Clarke, Terry M Jones, Vinidh Paleri, Nicholas White, Tim Woolford, Head & Neck Surgery Plastic Surgery, 2018
Julia A. Woolgar, Gillian L. Hall
The eruption cyst10 is a superficially located dentigerous cyst, presenting as a bluish swelling of the gum overlying an erupting tooth. They are most commonly seen in children, typically affecting the mandibular first molar and maxillary incisor teeth. Cyclosporin therapy is a recognized predisposing factor.7, 8
A foetus with a mass in the oral cavity: a rare case of oral eruption cyst
Published in Journal of Obstetrics and Gynaecology, 2022
Qianqian Gao, Yu Wang, Hanmin Liu, Jiao Chen
An eruption cyst (EC) is a benign, developmental odontogenic cyst occurring within soft tissues, and it can be in any form in the jaw arch (Aguiló et al. 1998). A number of complications, such as pain on sucking, airway obstruction, and aspiration, could be associated with a pathological congenital oral mass. Information on the diagnosis and its implications are therefore important. We report an oral mass that was diagnosed antenatally as EC. To our knowledge, this is the first case of prenatal observation of EC in China.
Orofacial clefts alter early life oral microbiome maturation towards higher levels of potentially pathogenic species: A prospective observational study
Published in Journal of Oral Microbiology, 2023
Corinna L. Seidel, Karin Strobel, Matthias Weider, Marco Tschaftari, Christoph Unertl, Ines Willershausen, Manuel Weber, André Hoerning, Patrick Morhart, Michael Schneider, Matthias W. Beckmann, Christian Bogdan, Roman G. Gerlach, Lina Gölz
After obtaining informed consent, 158 samples were collected from 40 study participants at two time points (T0, T1) from two different oral niches from each study participant from June 2020 to June 2021 by one experienced orthodontist specialized in treatment of neonates with CLP [9] and trained in preliminary experiments in taking of oral samples [19,32,33]. Due to drop-outs, 32 samples were excluded from further analyses (Figure 1). Therefore, the final sample size accounted to 126 samples from 32 study participants (Figure 1). The oral niches tongue (T) and cheek (C) were chosen as representatives of two of the three previously detected metaniches [19]. The third metaniche (gingival crevicular fluid and plaque) [19] is not expected in neonates since tooth eruption and congenital eruption cysts rarely occur in neonates [34]. Soft tissue samples were collected using sterile swabs patting over the area T (middle and anterior part) and C (right side) for about 10 s and parents were instructed not to feed the neonate up to two to three hours before sample collection. Regarding the cleft lip and palate (CLP) group, the first time point (T0) was defined as the first consultation at the Department of Orthodontics and Orofacial Orthopedics, which is a regular appointment for clinical investigation (T0: median 3d CLP group). On this appointment, orthodontists specialized in the treatment of newborns with orofacial cleft investigate the newborn, make a diagnosis and decide whether presurgical treatment with a palate plate is needed. In case of treatment need with presurgical infant orthopedics (PSIO), e.g. treatment with passive palate plates (passive alveolar molding = pAM) (Table 1), neonates have regular appointments every 4–6 weeks. The second time point (T1) was defined as a regular control appointment for the CLP group 4–5 weeks after birth (T1: median 32d CLP group). Treatment of CLP neonates does not include intake of antibiotics or other medications or surgical interventions within the first weeks of life (T0 – T1). Considering the control group, the first time point (T0) was defined as the second (‘U2’) routine investigation for children after birth (called ‘U’ investigations) performed in the Department of Gynecology and Obstetrics (median Ø2 d control group). The second time point (T1) was defined as the third (‘U3’) routine investigation at local pediatricians for the control group after birth (T1: median 31d control group). All samples were collected in sterile tubes and stored on dry ice within seconds after sample collection. For interim storage, all samples were frozen at −20°C for a maximum of 5 days under maintenance of an uninterrupted cold chain. Afterwards, all samples were frozen and stored at −80°C (CryoCube unit) in the research laboratory of the Department of Orthodontics and Orofacial Orthopedics. Further processing and DNA isolation of samples was performed at the research laboratory of the Department of Orthodontics and Orofacial Orthopedics. Microbiota analyses were conducted in the Institute of Clinical Microbiology, Immunology and Hygiene.