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Introduction to Vascular Complications in Oncology Patients
Published in Paloma Tejero, Hernán Pinto, Aesthetic Treatments for the Oncology Patient, 2020
As a serious complication in long-term lymphedema, the so-called Stewart-Treves syndrome or angiosarcoma that develops over an extremity previously affected with lymphedema becomes particularly significant. The time elapsed between the development of the lymphedema and the angiosarcoma diagnosis is 8–10 years on average; long-term patient follow-up is therefore very important. The evolution of angiosarcoma is aggressive, with fast locoregional growth, a tendency to early and remote metastasis, and high mortality [3].
Angiosarcoma
Published in Longo Caterina, Diagnosing the Less Common Skin Tumors, 2019
ASs arising in chronic lymphedema of the extremities (Stewart–Treves syndrome) clinically are characterized by confluent erythemato-violaceous nodules or papules in the lymphedema-affected region of the extremity. Rarely angiosarcomas occur following radiation therapy, with reported latency periods between 3 and 10 years. Most commonly women are affected after radiation therapy for breast cancer.
Skin and soft tissue
Published in Tor Wo Chiu, Stone’s Plastic Surgery Facts, 2018
Lymphoedema (lymphangiosarcoma) – Stewart–Treves syndrome – aggressive lymphangiosarcoma (often multifocal) in those with post-mastectomy lymphoedema. Such sarcomas are not regarded as radiation-induced as they are usually found outside the irradiated zone. The incidence ranges from 0.07% to 0.45% of 5 year survivors. The most common cause of death (8–16 months after diagnosis) is metastasis to lungs and chest wall; metastasis and local recurrence are common even after radical excision.
Primary Angiosarcoma of the Gastrointestinal Tract: A Systematic Review of the Literature
Published in Journal of Investigative Surgery, 2022
Dimitrios Schizas, Aikaterini Mastoraki, Ilias Giannakodimos, Alexios Giannakodimos, Afroditi Ziogou, Ioannis Katsaros, Maximos Frountzas, Ioannis Koutelidakis, Pantelis Vassiliu, Emmanouil Pikoulis
Several risk factors have been associated to angiosarcomas development with radiation therapy and chronic lymphedema (Stewart Treves Syndrome) being the most common [12]. Vascular malignancies must adhere to Cahan’s criteria in order to be characterized as post-radiated [44]. The estimated mean period between exposure to radiation and development of PGAS is 12.5 years, while the dose of administered radiation varies from 40 to 80 grays [45]. Occasionally, endothelial tumors may emerge in correlation with foreign bodies, prior chemotherapy and exogenous toxins, including vinyl chloride, thorotrast and arsenic [46]. Familiar syndromes, such as Neurofibromatosis type 1 and Maffucci syndrome, chronic inflammation, anal abscesses, fistulas and peritoneal dialysis constitute other suspected etiological parameters [47,48]. In the present systematic review, radiation and foreign bodies were potential risk factors at 28.2% of the included cases. The increased percentage (35.7%) of risk factors exposure in multifocal cases indicates an aggressive nature of the PGASs in their presence.
Risk factors for the development of local recurrence in extremity soft-tissue sarcoma
Published in Expert Review of Anticancer Therapy, 2022
Fabio Tirotta, Raza Sayyed, Robin L Jones, Andrew J Hayes
Similarly, longstanding lymphedema in a limb, which can be idiopathic or occur as a complication of surgery and/or radiotherapy (RT) to the draining lymph nodes, is associated with cutaneous angiosarcoma (Stewart-Treves Syndrome) which carries a high risk of both LR and distant dissemination [8]. Once again, these STS are often multicentric within a limb in the area of lymphedema and with a tendency for cutaneous infiltration and discontinuous spread. As such, attempts of WLE of the affected skin can be both morbid and may be associated with high rates of LR.
Cutaneous angiosarcoma: a case report of picking the battles in geriatrics
Published in Journal of Community Hospital Internal Medicine Perspectives, 2018
Corbin Pagano, Ana Cios, Stefan David
CA, alternatively known as Stewart-Treves syndrome, is a rare disease, has a poor prognosis, mainly affects elderly populations, and requires aggressive surgical therapy. The current case study did not focus on the pathological mechanisms nor treatment options available for this devastating disease. Instead, it was concerned with how patients and their family, as well as clinicians, face significant dilemmas in terms of its diagnosis and treatment, including the need to adjust the latter to meet reasonable, patient/family goals of care.