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Test Paper 4
Published in Teck Yew Chin, Susan Cheng Shelmerdine, Akash Ganguly, Chinedum Anosike, Get Through, 2017
Teck Yew Chin, Susan Cheng Shelmerdine, Akash Ganguly, Chinedum Anosike
Which one of the following statements regarding the testes is false? Tubular ectasia of the testis is a benign condition.Undescended testes are most commonly found in the inguinal canal.Metastases are most commonly from prostate and lung primary.Testicular cysts are mostly incidental and non-palpable.Sertoli cell tumour is the most common malignant testicular tumour.
Sex-Cord Tumor with Annular Tubules with Unusual Morphology in an Infant with Peutz-Jeghers Syndrome
Published in Fetal and Pediatric Pathology, 2022
Priyanka Maity, Nandini Das, Uttara Chatterjee, Dhananjay Basak
Sex-cord stromal tumors, other than SCTAT, associated with PJS are Sertoli cell tumors (both lipid-rich type and oxyphilic cell types), granulosa cell tumors, steroid cell tumors, Sertoli-Leydig cell tumor and unclassified sex-cord stromal tumors. Of these, Sertoli cell tumor is commonest.
Multiparametric ultrasonographic analysis of testicular tumors: a single-center experience in a collective of 49 patients
Published in Scandinavian Journal of Urology, 2020
Vincent Schwarze, Constantin Marschner, Bastian Sabel, Giovanna Negrão de Figueiredo, Julian Marcon, Michael Ingrisch, Thomas Knösel, Johannes Rübenthaler, Dirk-André Clevert
Except for one patient (pat. #14) in whom equivalent stiffness between Sertoli cell tumor and surrounding testicular parenchyma was registered, all included benign and malignant lesions presented hard in SE (malignant lesions: n = 20, benign lesions: n = 8).
Common markers of testicular Sertoli cells
Published in Expert Review of Molecular Diagnostics, 2021
Xu You, Qian Chen, Ding Yuan, Changcheng Zhang, Haixia Zhao
Currently, several testicular Sertoli cell markers (AMH, CK-18, Inh-B, M2A, AR, GATA-4, SOX9, VIM, FSHR, connexin 43) are widely used to study male infertility, reproductive toxicology, testicular cancer, and spermatogenesis, and due to their unique biological properties potentially could be useful in cell therapy in clinic [10,191]. In human medicine, testicular atrophy is considered to be a risk factor for testicular cancer, because the main characteristics of testicular atrophy are seminiferous tubules consisting of only Sertoli cells (i.e. no germ cells within the tubules) and incomplete spermatogenesis. For instance, re-expression of immature markers of Sertoli cells – including CK-18, AMH and desmin–are observed in human atrophic testis and testicular tumors [192]. Furthermore, determination of serum AMH and Inh-B is helpful in assessing testicular function, without need for stimulation tests, and orientates the etiological diagnosis of pediatric male hypogonadism [193,194]. A clinical study used inhibin B and AMH as Sertoli cell markers to investigate the relationship between infertility in adult males with congenital adrenal hyperplasia and testicular adrenal rest tumors that may originate during childhood [195]. In patients with testicular dysgenesis syndrome, Sertoli cell maturation is directly disrupted as evidenced by continuous expression of immature Sertoli cell markers (M2A, Inh-B and AMH), and absent expression of Sertoli cell maturation marker (AR) [64]. Inhibin bodies are regarded as a new marker for immature Sertoli cells in patients with abnormal Sertoli cell maturation (such as cryptorchidism, testicular tumors and infertility) [196]; Anniballo et al used CK-18, AMH and M2A as Sertoli cell markers to characterize Sertoli cells in testicular cords from patients showing testicular dysgenesis syndrome [197]. Brehm et al. regarded VIM, AMH, CK-18, M2A, AR and connexin 43 as Sertoli cell differentiation markers to study the state of Sertoli cell differentiation in both immature seminiferous tubules of adult patients with testicular dysgenesis syndrome and Sertoli cell tumor [198]. The clinical research results show that co-expression of CK-18 and AMH is commonly used diagnose spermatogonial arrest or Sertoli cell-only syndrome in infertile men as well as s in the vicinity of carcinoma in-situ (CIS) cells [11,12].