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Ovarian, Fallopian Tube, and Primary Peritoneal Cancer
Published in Pat Price, Karol Sikora, Treatment of Cancer, 2020
Robert D. Morgan, Andrew R. Clamp, Gordon C. Jayson
Female carriers of BRCA1 or BRCA2 mutations are offered prophylactic bilateral salpingo-oophorectomy, following completion of childbearing, in order to reduce the risk of developing ovarian cancer. However, the peritoneum remains at risk, with subsequent development of primary peritoneal carcinoma in approximately 1% of women who have undergone risk-reducing oophorectomy.20
Histopathological aspects of peritoneal malignancy
Published in Tom Cecil, John Bunni, Akash Mehta, A Practical Guide to Peritoneal Malignancy, 2019
Babatunde Rowaiye, Norman Carr
With our current state of knowledge, we cannot exclude the possibility that some cases of high-grade serous carcinoma do arise as primary peritoneal tumours, and this possibility is accommodated in the 2014 FIGO staging classification which allows for fallopian tube, ovarian, ‘tubal/ovarian’ and peritoneal primaries [53]. Nevertheless, cases should be categorised as primary peritoneal carcinoma only if any ovarian involvement is confined to the surface of the ovary or involves the stroma with a tumour size <5 × 5 mm, and the extra-ovarian disease is greater than the surface ovarian involvement [54]. It is likely that cases categorised as primary peritoneal carcinoma will become increasingly rare as pathologists follow guidelines recommending that the fimbrial ends of the fallopian tubes are entirely submitted for histology to exclude the possibility of STIC or primary tubal carcinoma [55]. Improved recognition of the primary site of these tumours will allow for more accurate staging and increase our understanding of how they behave.
Malignant disease of the ovary
Published in Helen Bickerstaff, Louise C Kenny, Gynaecology, 2017
Primary peritoneal carcinoma (PPC) is a high-grade pelvic serous carcinoma. It is histologically indistinct from tumours arising from the Fallopian tube or ovary. There are, however, morphological differences between the two groups based on clinical findings at laparotomy. Criteria for diagnosis includes:
Changing patterns of referral into a family history clinic and detection of ovarian cancer: a retrospective 10-year review
Published in Journal of Obstetrics and Gynaecology, 2022
K. G. Smallwood, S. Crockett, V. Huang, V. Cullimore, J. Davies, G. Satti, A Phillips
Two patients developed primary peritoneal carcinoma subsequent to risk reducing surgery, with an interval from surgery to diagnosis of 40 and 72 months respectively. Neither of these patients were found to have STIC at initial surgery. Patient 1 presented with abdominal pain; however little treatment information is available as she was treated at another unit. Patient 2 presented to the upper GI team on a two week wait referral with dyspepsia. She had a normal oesophagogastroduodenoscopy, however a CT scan showed significant omental cake. Primary peritoneal cancer was diagnosed on ultrasound guided biopsy and the patient was worked up for cytoreductive surgery. Unfortunately, she was deemed unfit due to cardiac problems and therefore was offered primary chemotherapy. Both patients died during the follow up period at 6 and 43 months post diagnosis respectively. These are the only deaths in our cohort. The rate of developing PPC following risk reducing BSO in our cohort was therefore 0.7%. Patient characteristics are found in Table 4.
Unanticipated 30-day readmission following rectosigmoid resection at the time of cytoreductive surgery in patients with advanced stage ovarian cancer
Published in Journal of Obstetrics and Gynaecology, 2021
Brooke E. Sanders, Samah Saharti, Katharina Laus, Robert E. Bristow, Ramez N. Eskander
In collaboration with the department of surgical pathology, eligible patients were identified using the institutional pathology tumour data registry. Four hundred and twenty-nine patient files were reviewed with 50 unique patients eligible for inclusion. Individuals with pathology reports indicating resection of rectum and sigmoid colon in conjunction with tissue samples positive for ovarian, fallopian tube or primary peritoneal carcinoma were identified and charts abstracted for independent review. All pathology and surgical operative reports were reviewed to ensure that a rectosigmoid colectomy with primary anastomosis was completed at the time of surgical cytoreduction, and to also confirm appropriate histology and primary disease site. Rectosigmoid resections were performed in each case to facilitate optimal surgical cytoreduction. Patients were excluded if protective ileostomies were created at the time of surgery.
Pattern of endocrine treatment for epithelial ovarian cancer in the Southeast medical region of Sweden: a population-based study
Published in Acta Oncologica, 2019
Ebba Bagge, Ulrica Beiron, Susanne Malander, Per Rosenberg, Elisabeth Åvall-Lundqvist
We used the population-based Southeast Medical Region Quality Registry for Gynecological Cancer (SMRQRGC) to identify eligible patients. The Southeast medical region is one of six in Sweden, encompassing a population of 1.1 million inhabitants. Reporting to the Swedish National Cancer Registry, which started in 1958, is mandatory and the registry has over 95% coverage of all malignant tumors and 99% of the tumors registered are histologically verified [18]. The coverage between SMRQRGC and the national cancer registry is approximately 100% [19]. Inclusion criteria were: age at least 18 years, histologically verified epithelial ovarian, fallopian tube or primary peritoneal carcinoma diagnosed between January 1st, 2000 and December 31st, 2013 and ET for at least four weeks. Since we were interested in outcome we excluded patients (n = 2) who received ET for less than 4 weeks, see Flow chart (Figure 1). The ethical review board at Linköping University approved the study and deemed a separate study-specific consent as not needed.